Current Hepatitis Reports

, Volume 10, Issue 4, pp 262–268 | Cite as

Management of Hepatitis B Virus Coinfection: HIV, Hepatitis C Virus, Hepatitis D Virus

  • Kalyan Ram Bhamidimarri
  • James Park
  • Douglas DieterichEmail author
Hepatitis B: Epidemiology, Natural History, Treatment, and Transplantation (Thomas Berg and Steven-Huy Han, Section Editors)


Coinfection of hepatitis B virus (HBV) with HIV, hepatitis C virus (HCV) and hepatitis D virus (HDV) is common because of shared modes of transmission. Increasing prevalence of high risk sexual behavior and intra venous drug use (IVDU) contributes to a majority of the cases with coinfection. Occult HBV or prior HBV infection is frequently encountered in patients coinfected with HIV or HCV. Although HBV is a preventable disease, failure to screen and inadequate vaccination in the high risk individuals account for vast under-recognition of the cases with HBV infection. Chronic liver disease from viral hepatitis B and C has emerged as the major cause of morbidity and mortality worldwide as well as in the United States. This is especially true in cases coinfected with HIV. The potential long term risks of untreated hepatitis include cirrhosis and hepatocellular carcinoma. There have been several advancements in the understanding of natural history and management options of chronic viral hepatitis. This article discusses and reviews the natural history, epidemiology, and management of HBV patients coinfected with HIV, HCV, or HDV. It includes an updated summary of the outcomes with liver transplantation and post transplant recurrence in the coinfected population with HBV. It also discusses the role of occult HBV in HIV and HCV coinfection respectively.


Hepatitis B virus Chronic hepatitis Coinfection Hepatitis B Hepatitis C Hepatitis D HIV 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Kalyan Ram Bhamidimarri
    • 1
  • James Park
    • 1
  • Douglas Dieterich
    • 1
    Email author
  1. 1.Division of Liver Diseases, Department of MedicineThe Mount Sinai Medical CenterNew YorkUSA

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