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The Emerging Role of Liquid Biopsies in Lymphoproliferative Disorders

  • T-Cell and Other Lymphoproliferative Malignancies (J Zain, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

Lymphomas represent clinically and molecularly heterogeneous diseases with variable presentations, treatment algorithms, and outcomes. As treatment options continue to expand, more sophisticated prognostic and predictive biomarkers are needed to guide personalized treatment approaches.

Recent Findings

Liquid biopsies, in which the sequencing of circulating tumor DNA (ctDNA) in peripheral blood serves as a surrogate for a tumor biopsy, are now being studied across cancer subtypes, including in lymphoid malignancies. Recent studies have demonstrated the potential of these techniques to improve prognostication and guide individualized treatment strategies, providing a significant advance in the field of precision medicine.

Summary

In this review, we describe the sequencing platforms currently available for analysis of ctDNA in lymphoma and their potential applications in clinical practice, which seem poised to refine treatment paradigms across lymphoma subtypes.

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  1. Dana-Farber Cancer Institute, Boston, MA, USA

    Jennifer Crombie & Philippe Armand

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  1. Jennifer Crombie
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  2. Philippe Armand
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Correspondence to Jennifer Crombie.

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Philippe Armand reports interest from Adaptive, BMS, Merck, Affimed, Pfizer, and Roche, outside the submitted work. Jennifer Crombie declares that she has no conflicts of interest.

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This article is part of the Topical Collection on T-Cell and Other Lymphoproliferative Malignancies

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Crombie, J., Armand, P. The Emerging Role of Liquid Biopsies in Lymphoproliferative Disorders. Curr Hematol Malig Rep 14, 11–21 (2019). https://doi.org/10.1007/s11899-019-0493-y

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