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A Review of Autologous Stem Cell Transplantation in Lymphoma

  • B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (D Persky, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients.

Recent Findings

There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL.

Summary

Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.

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Acknowledgments

This work was supported by grant P30 CA023074 from the National Cancer Institute, National Institutes of Health, Bethesda, MD.

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Author notes

  1. UZ, FA, and AA equally contributed as first co-authors.

Authors and Affiliations

  1. Department of Medicine, University of Arizona, Tucson, AZ, USA

    Umar Zahid & Irbaz Bin Riaz

  2. College of Public Health, University of Arizona, Tucson, AZ, USA

    Umar Zahid

  3. Department of Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC, USA

    Faisal Akbar

  4. Department of Medicine, Hematology and Oncology, University of Arizona, Tucson, AZ, USA

    Akshay Amaraneni

  5. Internal medicine Residency program, Department of Medicine, University of Arizona, Tucson, AZ, USA

    Muhammad Husnain & Onyee Chan

  6. College of Pharmacy, University of Arizona, Tucson, AZ, USA

    Ali McBride

  7. Department of Hematology and Oncology, University of Arizona, Tucson, AZ, USA

    Ahmad Iftikhar

  8. Department of medicine, Hematology Oncology and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA

    Faiz Anwer

  9. Department of Medicine, Division of Hematology, Oncology, Blood & Marrow Transplantation, Multiple Myeloma Program, University of Arizona, Tucson, AZ, 85721, USA

    Faiz Anwer

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  1. Umar Zahid
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Contributions

UZ, FA, AA, MH, OC, IBR, AM, AI, and FAα designed the study. All coauthors searched for studies, extracted data, summarized results, developed the manuscript, helped with final edits, and wrote the paper. Ali McBride PharmD MS and Faiz Anwer MD FACP will share senior authorship for this manuscript, and FAα will serve as corresponding author.

Corresponding author

Correspondence to Faiz Anwer.

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Conflict of Interest

Umar Zahid, Faisal Akbar, Akshay Amaraneni, Muhammad Husnain, Onyee Chan, Irbaz Bin Riaz, Ali McBride, and Ahmad Iftikhar each declare no potential conflicts of interest.

Faiz Anwer reports grants from the National Cancer Institute and National Institutes of Health.

Human and Animal Rights

This article does not contain any data involving human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on B-cell NHL, T-cell NHL, and Hodgkin Lymphoma

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Zahid, U., Akbar, F., Amaraneni, A. et al. A Review of Autologous Stem Cell Transplantation in Lymphoma. Curr Hematol Malig Rep 12, 217–226 (2017). https://doi.org/10.1007/s11899-017-0382-1

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