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Next-Generation Sequencing-Based Panel Testing for Myeloid Neoplasms

  • Acute Myeloid Leukemias (R Stone, Section Editor)
  • Published:
Current Hematologic Malignancy Reports Aims and scope Submit manuscript

Abstract

Our ability to interrogate a broad array of genetic alterations in myeloid neoplasm has increased significantly with the advance in next-generation sequencing (NGS). In addition to morphologic examination, flow cytometry, and cytogenetics, NGS-based testing can add additional information to the diagnostic workup. More than a dozen myeloid-focused NGS-based panels are now available from commercial and academic laboratories. In this review, we examine the content of these panels in the context of our current understanding of driver alterations in myeloid neoplasms. With improved turnaround time, decreasing costs, and an expanding knowledge of the therapeutic and prognostic significance of the detected variants, NGS-based panel testing is likely to play a major role in the management of patients with myeloid neoplasm in the coming decade.

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Dr. Frank C. Kuo and Dr. Fei Dong each declare no potential conflicts of interest.

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  1. Center for Advanced Molecular Diagnostics, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Frank C. Kuo & Fei Dong

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  1. Frank C. Kuo
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Correspondence to Frank C. Kuo.

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This article is part of the Topical Collection on Acute Myeloid Leukemias

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Kuo, F.C., Dong, F. Next-Generation Sequencing-Based Panel Testing for Myeloid Neoplasms. Curr Hematol Malig Rep 10, 104–111 (2015). https://doi.org/10.1007/s11899-015-0256-3

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