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Relapsed Hodgkin Lymphoma: Management Strategies

  • Lymphomas (G Nowakowski, Section Editor)
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Abstract

Although Hodgkin lymphoma (HL) is largely curable with first-line therapy, approximately one-third of patients will not have a complete response to frontline treatment or will subsequently relapse. Only 50 % of these patients will be effectively salvaged with conventional therapies. The prognosis is particularly poor for those patients with chemotherapy refractory disease, who are unable to obtain even transient disease control, and for patients who relapse following high dose chemotherapy and autologous stem cell transplant. In this review, we summarize the most recent updates on the management of patients with relapsed HL, the role of novel therapies such as brentuximab vedotin, and an overview of promising new agents currently under investigation. We also discuss the role of consolidation strategies such as high-dose chemotherapy and autologous stem cell transplant, and reduced-intensity allogeneic hematopoietic stem cell transplant, and the need for new strategies in the elderly patient population.

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Acknowledgments

CD is supported by a Clinical Investigator Career Development Award from the Lymphoma Research Foundation.

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Conflict of Interest

Dr. Francesca Montanari declares no potential conflicts of interest.

Dr. Catherine Diefenbach is a consultant for Seattle Genetics.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Medicine, New York University School of Medicine, NYU Cancer Institute, 240 East 38th Street, 19th Floor, New York, NY, 10016, USA

    Francesca Montanari & Catherine Diefenbach

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  1. Francesca Montanari
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Correspondence to Catherine Diefenbach.

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Montanari, F., Diefenbach, C. Relapsed Hodgkin Lymphoma: Management Strategies. Curr Hematol Malig Rep 9, 284–293 (2014). https://doi.org/10.1007/s11899-014-0220-7

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