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Large granular lymphocyte leukemia

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Abstract

Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3+) or natural killer (NK)-cell (CD3−) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosuppressive therapies; in contrast, aggressive T-cell or NK-cell LGL leukemias require intensive chemotherapy regimens. Novel targeted therapies are currently being tested in clinical studies.

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Authors and Affiliations

  1. Penn State Cancer Institute, Penn State College of Medicine, 500 University Drive, H072, Hershey, PA, 17033, USA

    Thomas P. Loughran

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  1. Lubomir Sokol
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  2. Thomas P. Loughran
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Correspondence to Thomas P. Loughran.

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Sokol, L., Loughran, T.P. Large granular lymphocyte leukemia. Curr Hematol Malig Rep 2, 278–282 (2007). https://doi.org/10.1007/s11899-007-0038-7

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  • DOI: https://doi.org/10.1007/s11899-007-0038-7

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