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Synthesizing Markers of Kidney Injury in Acute Decompensated Heart Failure: Should We Even Keep Looking?

  • Biomarkers of Heart Failure (WH Tang & J Grodin, Section Editors)
  • Published:
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Abstract

Purpose of Review

This review discusses evidence that has accumulated over the years on the diagnostic and prognostic utility of biomarkers of kidney injury in the setting of acute decompensated heart failure.

Recent Findings

Despite numerous studies evaluating several different biomarkers both in the serum and urine, the current body of evidence does not support routine use of any of these biomarkers for the purposes of diagnosis of acute kidney injury or for prognosis after hospitalization for acute decompensated heart failure. All studies are observational in nature and, as such, are likely limited by numerous confounders, the most important of which is modification of decongestive therapy in response to worsening renal function. More recent evidence suggests that worsening renal function or kidney injury does not always portend poor outcomes after hospitalization for heart failure.

Summary

There is currently no conclusive evidence to recommend the routine use of biomarkers of kidney injury in acute decompensated heart failure.

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Authors and Affiliations

  1. Department of Medicine, Icahn School of Medicine at Mount Sinai/St. Luke’s-Roosevelt Hospital Center, New York, NY, USA

    Alexander S. Manguba Jr & Xavier Vela Parada

  2. Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Steven G. Coca

  3. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Anuradha Lala

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  1. Alexander S. Manguba Jr
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Correspondence to Anuradha Lala.

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Dr. Coca reports personal fees and other from RenalytixAI, personal fees from CHF Solutions, personal fees from Quark, personal fees from Takeda, personal fees from Janssen, personal fees and other from pulseData, personal fees from Goldfinch, personal fees from Relypsa, outside the submitted work.

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This article is part of the Topical Collection on Biomarkers of Heart Failure

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Manguba, A.S., Vela Parada, X., Coca, S.G. et al. Synthesizing Markers of Kidney Injury in Acute Decompensated Heart Failure: Should We Even Keep Looking?. Curr Heart Fail Rep 16, 257–273 (2019). https://doi.org/10.1007/s11897-019-00448-9

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