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Clinical Phenotyping of Heart Failure with Biomarkers: Current and Future Perspectives

Current Heart Failure Reports volume 14, pages 106–116 (2017)Cite this article

Abstract

Introduction

Heart failure (HF) is a complex clinical syndrome with diverse risk factors and etiologies, differing underlying pathophysiology, and large phenotypic heterogeneity.

Recent Findings

Advances in imaging techniques coupled with clinical trials that targeted only in those with impaired left ventricular ejection fraction (LVEF) have largely shaped the current management strategy for HF that focuses predominantly in patients with systolic HF. In contrast, there are no effective treatments for HF with preserved ejection fraction (HFpEF). Instead of this “one-size-fits-all” approach to treatment, better precision to define HF phenotypic classifications may lead to more efficient and effective HF disease management.

Conclusion

Integrating variables—including clinical variables, HF biomarkers, imaging, genotypes, metabolomics, and proteomics—can identify different pathophysiologies, lead to more precise phenotypic classification, and warrant investigation in future clinical trials.

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Fig. 1

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Affiliations

  1. Department of Cardiovascular Medicine, Heart and Vascular Institute, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH, 44915, USA

    Vichai Senthong & W. H. Wilson Tang

  2. Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

    Vichai Senthong

  3. Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, OH, USA

    Jennifer L. Kirsop & W. H. Wilson Tang

  4. Center for Clinical Genomics, Cleveland Clinic, Cleveland, OH, USA

    W. H. Wilson Tang

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  1. Vichai Senthong
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Vichai Senthong and Jennifer L. Kirsop declare that they have no conflict of interest.

W.H. Wilson Tang has received grants from the National Institutes of Health (R01HL103931, P20HL113452, R01DK106000, R01HL126827) outside of the submitted work.

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This article is part of the Topical Collection on Biomarkers of Heart Failure

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Senthong, V., Kirsop, J.L. & Tang, W.H.W. Clinical Phenotyping of Heart Failure with Biomarkers: Current and Future Perspectives. Curr Heart Fail Rep 14, 106–116 (2017). https://doi.org/10.1007/s11897-017-0321-4

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Keywords

  • Heart failure
  • Phenotype
  • Therapeutics
  • Pathophysiology