Current Heart Failure Reports

, Volume 14, Issue 1, pp 48–58 | Cite as

Thyroid Dysfunction and Heart Failure: Mechanisms and Associations

  • Hernando Vargas-UricoecheaEmail author
  • Anilza Bonelo-Perdomo
Comorbidities of Heart Failure (C Angermann and F Edelmann, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Comorbidities of Heart Failure


Purpose of Review

The purpose of this review is to provide an update on the current knowledge of the pathophysiology, the mechanisms, and the cardiovascular impact of the different stages of thyroid dysfunction (TD) in heart failure (HF) patients.

Recent Finding

The influence of thyroid hormones (THs) on the cardiovascular system involves the regulation of key processes related to maintenance of cardiac function; however, there are no long-term studies available showing that intervening the TD changes the incidence or the prognosis in HF individuals. Future research shall focus on the effects of cardiovascular morbidity and mortality associated with different treatment modalities for hyper and hypothyroidism.


TD has been associated with different clinical results in HF individuals; treatment with THs in patients with hypothyroidism improves cardiovascular risk factors, but the effect on cardiovascular events has not been assessed in randomized, controlled trials.


Heart failure Thyroid hormones Hyperthyroidism Hypothyroidism 


Compliance with Ethical Standards

Conflict of Interest

Hernando Vargas-Uricoechea and Anilza Bonelo-Perdomo declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Hernando Vargas-Uricoechea
    • 1
    Email author
  • Anilza Bonelo-Perdomo
    • 2
  1. 1.Division of Endocrinology and Metabolism, Internal Medicine DepartmentUniversidad del CaucaPopayánColombia
  2. 2.Division of Basic Immunology and Biomedical SciencesUniversidad del Valle-Campus San FernandoCaliColombia

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