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MRI Assessment of Diastolic and Systolic Intraventricular Pressure Gradients in Heart Failure

  • Prevention of Heart Failure (M S J Sutton, Section Editor)
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Abstract

A deep phenotypic characterization of heart failure (HF) is important for a better understanding of its pathophysiology. In particular, novel noninvasive techniques for the characterization of functional abnormalities in HF with preserved ejection fraction are currently needed. While echocardiography is widely used to assess ventricular function, standard echocardiographic techniques provide a limited understanding of ventricular filling. The application of fluid dynamics theory, along with assessments of flow velocity fields in multiple dimensions in the ventricle, can be used to assess intraventricular pressure gradients (IVPGs), which in turn may provide valuable insights into ventricular diastolic and systolic function. Advances in imaging techniques now allow for accurate estimations of systolic and diastolic IVPGs, using noninvasive methods that are easily applicable in clinical research. In this review, we describe the basic concepts regarding intraventricular flow measurements and the derivation of IVPGs. We also review existing literature exploring the role of IVPGs in HF.

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Authors and Affiliations

  1. University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Snigdha Jain

  2. IBiTech-bioMMeda, iMinds Medical IT, Ghent University, Ghent, Belgium

    Francisco J. Londono, Patrick Segers, Thierry C. Gillebert & Marc De Buyzere

  3. Division of Cardiology, Ghent University Hospital, Ghent, Belgium

    Francisco J. Londono, Patrick Segers, Thierry C. Gillebert, Marc De Buyzere & Julio A. Chirinos

  4. Hospital of University of Pennsylvania, 3400 Spruce Street Gates 9021, Philadelphia, PA, 19060, USA

    Francisco J. Londono & Julio A. Chirinos

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  1. Snigdha Jain
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Snigdha Jain, Francisco J. Londono, Patrick Segers, Thierry C. Gillebert, and Marc De Buyzere declare that they have no conflict of interest.

Julio A. Chirinos reports personal fees from Brystol Myers Squibb, OPKO Healthcare, Fukuda Denshi, Microsoft and Merck, grants from National Institutes of Health, American College of Radiology Network, Fukuda Denshi, Microsoft, Brystol Myers Squibb, non-financial support from Atcor Medical, outside the submitted work; In addition, Dr. Chirinos is named as inventor in a pending University of Pennsylvania patent application for the use of inorganic nitrates/nitrites for the treatment of HFpEF.

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Jain, S., Londono, F.J., Segers, P. et al. MRI Assessment of Diastolic and Systolic Intraventricular Pressure Gradients in Heart Failure. Curr Heart Fail Rep 13, 37–46 (2016). https://doi.org/10.1007/s11897-016-0281-0

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