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MitraClip and Transcatheter Aortic Valve Implantation (TAVI): State of the Art 2015

  • Comorbidities of Heart Failure (C. Angermann, Section Editor)
  • Published:
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Abstract

The feasibility, safety, and efficacy of transcatheter heart valve (THV) therapies such as MitraClip and transcatheter aortic valve implantation (TAVI) have made them valid therapeutic options in high-risk or inoperable patients with heart failure (HF). Randomized controlled trials (RCTs) demonstrated noninferiority and superiority in terms of efficacy for 12 months of TAVI versus surgical replacement and optimal medical therapy, respectively. With regard to MitraClip, noninferiority was first demonstrated in four subgroups at 12 months and then later at 4-year follow-up. This difference in clinical outcomes between the two therapies is consistent with the discrepancy in the level of recommendation and class of evidence for TAVI and MitraClip according to recent international guidelines (IB vs. IIbC, respectively). Data from ongoing RCTs and national registries will help establish the reciprocal role and hierarchy among THV therapies, surgery, and medical treatment in patients with HF.

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Authors and Affiliations

  1. University Hospital of Zurich, Rämistrasse 100, 8091-CH, Zurich, Switzerland

    Alessandro Candreva, Francesco Maisano & Maurizio Taramasso

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  1. Alessandro Candreva
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  2. Francesco Maisano
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  3. Maurizio Taramasso
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Correspondence to Alessandro Candreva.

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Alessandro Candreva, Francesco Maisano, and Maurizio Taramasso declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Comorbidities of Heart Failure

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Candreva, A., Maisano, F. & Taramasso, M. MitraClip and Transcatheter Aortic Valve Implantation (TAVI): State of the Art 2015. Curr Heart Fail Rep 12, 379–388 (2015). https://doi.org/10.1007/s11897-015-0275-3

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