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The Relationship Between Cardiac Resynchronization Therapy and Diastolic Function

  • Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (AK Hasan, Section Editor)
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Abstract

Cardiac resynchronization therapy (CRT) improves measures of systolic function and clinical status. However, its effect on diastolic function is not well established. Commonly used parameters of diastolic function are measured from echocardiography, using pulse wave and tissue Doppler technologies, as well as timing and deformation data. Review of the existing studies that address the relationship between diastolic function and CRT shows conflicting data, but general trends can be deduced. Baseline elevated filling pressure appears to identify patients most likely to derive improvement in that particular parameter. Intrinsic relaxation does not appear to be significantly impacted by CRT. Generally, changes in diastolic properties after CRT appear to be linked to changes in systolic function. Specific therapy aimed at diastolic asynchrony is lacking, partly due to an unclear relationship between diastolic asynchrony and diastolic dysfunction, and the inability to specifically impact diastolic timing with a systolic intervention such as CRT.

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Conflict of Interest

Gregory F. Egnaczyk has received compensation from Medtronic for service as a consultant.

Eugene S. Chung has received financial support through a grant from Boston Scientific, and has received compensation from Boston Scientific and Medtronic for service as a consultant.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. The Heart and Vascular Center at The Christ Hospital, 2123 Auburn Ave, Ste 137, Cincinnati, OH, 45219, USA

    Gregory F. Egnaczyk & Eugene S. Chung

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  1. Gregory F. Egnaczyk
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  2. Eugene S. Chung
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Correspondence to Eugene S. Chung.

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Egnaczyk, G.F., Chung, E.S. The Relationship Between Cardiac Resynchronization Therapy and Diastolic Function. Curr Heart Fail Rep 11, 64–69 (2014). https://doi.org/10.1007/s11897-013-0181-5

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  • DOI: https://doi.org/10.1007/s11897-013-0181-5

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