Skip to main content

Advertisement

SpringerLink
Log in

Mineralocorticoid-receptor Antagonists in Heart Failure: A Tale of Serendipity and Success

  • Clinical Trial Report
  • Published:
Current Heart Failure Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone evaluation study investigators. N Engl J Med. 1999;341:709–17.

    Article  PubMed  CAS  Google Scholar 

  2. Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–21.

    Article  PubMed  CAS  Google Scholar 

  3. Rocha R, Rudolph AE, Frierdich GE, et al. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol. 2002;283:H1802–10.

    CAS  Google Scholar 

  4. Weber KT. Aldosterone and spironolactone in heart failure. N Engl J Med. 1999;341:753–5.

    Article  PubMed  CAS  Google Scholar 

  5. Okubo S, Niimura F, Nishimura H, et al. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Investig. 1997;99:855–60.

    Article  PubMed  CAS  Google Scholar 

  6. Jorde UP, Vittorio T, Katz SD, et al. Elevated plasma aldosterone levels despite complete inhibition of the vascular angiotensin-converting enzyme in chronic heart failure. Circulation. 2002;106:1055–7.

    Article  PubMed  CAS  Google Scholar 

  7. Beggah AT, Escoubet B, Puttini S, et al. Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes. Proc Natl Acad Sci USA. 2002;99:7160–5.

    Article  PubMed  CAS  Google Scholar 

  8. Le Menuet D, Viengchareun S, Muffat-Joly M, et al. Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse models. Mol Cell Endocrinol. 2004;217:127–36.

    Article  PubMed  Google Scholar 

  9. Funder JW. Reconsidering the roles of the mineralocorticoid receptor. Hypertension. 2009;53:286–90.

    Article  PubMed  CAS  Google Scholar 

  10. Qin W, Rudolph AE, Bond BR, et al. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ Res. 2003;93:69–76.

    Article  PubMed  CAS  Google Scholar 

  11. Lindenfeld J, Albert NM, Boehmer JP et al. HFSA 2010 Comprehensive Heart Failure Practice Guideline. J Card Fail. 16:e1-194

  12. McMurray JJ, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362:767–71.

    Article  PubMed  CAS  Google Scholar 

  13. Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001;345:1667–75.

    Article  PubMed  CAS  Google Scholar 

  14. Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:2049–57.

    Article  PubMed  CAS  Google Scholar 

  15. Juurlink DN, Mamdani MM, Lee DS, et al. Rates of hyperkalemia after publication of the randomized aldactone evaluation study. N Engl J Med. 2004;351:543–51.

    Article  PubMed  CAS  Google Scholar 

  16. Albert NM, Yancy CW, Liang L, et al. Use of aldosterone antagonists in heart failure. JAMA: J Am Med Assoc. 2009;302:1658–65.

    Article  CAS  Google Scholar 

Download references

Disclosures

No potential conflicts of interest relevant to this article were reported.

Author information

Authors and Affiliations

  1. Department of Medicine, Leon H. Charney Division of Cardiology, New York University Langone Medical Center, 530 First Avenue, Skirball 9R, New York, NY, 10016, USA

    Alex Reyentovich & Stuart D. Katz

Authors
  1. Alex Reyentovich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stuart D. Katz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stuart D. Katz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reyentovich, A., Katz, S.D. Mineralocorticoid-receptor Antagonists in Heart Failure: A Tale of Serendipity and Success. Curr Heart Fail Rep 8, 87–90 (2011). https://doi.org/10.1007/s11897-011-0055-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11897-011-0055-7

Keywords

Search

Navigation