Skip to main content

Advertisement

Log in

The role of echocardiography in cardiac resynchronization therapy

  • Published:
Current Heart Failure Reports Aims and scope Submit manuscript

Abstract

Echocardiography is the most important imaging tool for managing heart failure patients. With the advent of cardiac resynchronization therapy (CRT), its role has been broadened by data pertaining to patient selection, optimization of device settings, and outcome assessment. Beyond ejection fraction determination, echocardiographic methods that measure tissue velocity and strain may have the capability to determine degree of mechanical dyssynchrony and possibly predict likelihood of benefit with CRT. After implantation (as the ventricles are fully paced, adjusting the atrioventricular delay [atrioventricular optimization]), the timing of the right ventricular and left ventricular lead stimulation (ventricular-ventricular optimization) to achieve maximal cardiac filling or ejection may be clinically important. Atrioventricular and ventricular-ventricular optimization rely on echocardiography to determine optimal values. In long-term follow-up, serial measurement of left ventricular volume has significant correlation with mortality and is a reasonable measure of successful CRT; echocardiography is uniquely suited for this purpose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Hunt SA, Abraham WT, Chin MH, et al.: ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005, 112:e154–e235.

    Article  PubMed  Google Scholar 

  2. Bax JJ, Abraham T, Barold SS, et al.: Cardiac resynchronization therapy: part 1-issues before device implantation. J Am Coll Cardiol 2005, 46:2153–2167.

    Article  PubMed  Google Scholar 

  3. Bax JJ, Abraham T, Barold SS, et al.: Cardiac resynchronization therapy: part 2-issues during and after device implantation and unresolved questions. J Am Coll Cardiol 2005, 46:2168–2182.

    Article  PubMed  Google Scholar 

  4. Dickstein K, Cohen-Solal A, Filippatos G, et al.: ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008, 10:933–989.

    Article  PubMed  Google Scholar 

  5. UK National Institute for Health and Clinical Excellence. Cardiac resynchronisation therapy for the treatment of heart failure. Available at http://www.nice.org.uk/nicemedia/pdf/TA120Guidance.pdf. Accessed December 2008.

  6. Bleeker GB, Schalij MJ, Molhoek SG, et al.: Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. J Cardiovasc Electrophysiol 2004, 15:544–549.

    PubMed  Google Scholar 

  7. Bleeker GB, Schalij MJ, Molhoek SG, et al.: Frequency of left ventricular dyssynchrony in patients with heart failure and a narrow QRS complex. Am J Cardiol 2005, 95:140–142.

    Article  PubMed  Google Scholar 

  8. Abraham WT, Fisher WG, Smith AL, et al.: Cardiac resynchronization in chronic heart failure. N Engl J Med 2002, 346:1845–1853.

    Article  PubMed  Google Scholar 

  9. Pitzalis MV, Iacoviello M, Romito R, et al.: Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy. J Am Coll Cardiol 2005, 45:65–69.

    Article  PubMed  Google Scholar 

  10. Pitzalis MV, Iacoviello M, Romito R, et al.: Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. J Am Coll Cardiol 2002, 40:1615–1622.

    Article  PubMed  Google Scholar 

  11. Marcus GM, Rose E, Viloria EM, et al.: Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol 2005, 46:2208–2214.

    Article  PubMed  Google Scholar 

  12. Chung ES, Leon AR, Tavazzi L, et al.: Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 2008, 117:2608–2616.

    Article  PubMed  Google Scholar 

  13. Abraham TP, Dimaano VL, Liang HY: Role of tissue Doppler and strain echocardiography in current clinical practice. Circulation 2007, 116:2597–2609.

    Article  PubMed  Google Scholar 

  14. Bax JJ, Molhoek SG, van Erven L, et al.: Usefulness of myocardial tissue Doppler echocardiography to evaluate left ventricular dyssynchrony before and after biventricular pacing in patients with idiopathic dilated cardiomyopathy. Am J Cardiol 2003, 91:94–97.

    Article  PubMed  Google Scholar 

  15. Yu CM, Fung WH, Lin H, et al.: Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol 2003, 91:684–688.

    Article  PubMed  Google Scholar 

  16. D’Hooge J, Heimdal A, Jamal F, et al.: Regional strain and strain rate measurements by cardiac ultrasound: principles, implementation and limitations. Eur J Echocardiogr 2000, 1:154–170. [Published erratum appears in Eur J Echocardiogr 2000, 1:295–299.]

    Article  PubMed  CAS  Google Scholar 

  17. Miyazaki C, Powell BD, Bruce CJ, et al.: Comparison of echocardiographic dyssynchrony assessment by tissue velocity and strain imaging in subjects with or without systolic dysfunction and with or without left bundle-branch block. Circulation 2008, 117:2617–2625.

    Article  PubMed  Google Scholar 

  18. Yu CM, Zhang Q, Fung JW, et al.: A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging. J Am Coll Cardiol 2005, 45:677–684.

    Article  PubMed  Google Scholar 

  19. Delgado V, Ypenburg C, van Bommel RJ, et al.: Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy. J Am Coll Cardiol 2008, 51:1944–1952.

    Article  PubMed  Google Scholar 

  20. Gorcsan J 3rd, Tanabe M, Bleeker GB, et al.: Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. J Am Coll Cardiol 2007, 50:1476–1483.

    Article  PubMed  Google Scholar 

  21. Kapetanakis S, Kearney MT, Siva A, et al.: Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony. Circulation 2005, 112:992–1000.

    Article  PubMed  CAS  Google Scholar 

  22. Bleeker GB, Kaandorp TA, Lamb HJ, et al.: Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 2006, 113:969–976.

    Article  PubMed  Google Scholar 

  23. Ascione L, Muto C, Iengo R, et al.: End-diastolic wall thickness as a predictor of reverse remodelling after cardiac resynchronization therapy: a two-dimensional echocardiographic study. J Am Soc Echocardiogr 2008, 21:1055–1061.

    Article  PubMed  Google Scholar 

  24. Gradaus R, Stuckenborg V, Loher A, et al.: Diastolic filling pattern and left ventricular diameter predict response and prognosis after cardiac resynchronisation therapy. Heart 2008, 94:1026–1031.

    Article  PubMed  CAS  Google Scholar 

  25. Wang YC, Hwang JJ, Yu CC, et al.: Provocation of masked left ventricular mechanical dyssynchrony by treadmill exercise in patients with systolic heart failure and narrow QRS complex. Am J Cardiol 2008, 101:658–661.

    Article  PubMed  Google Scholar 

  26. Hochleitner M, Hortnagl H, Ng CK, et al.: Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol 1990, 66:198–202.

    Article  PubMed  CAS  Google Scholar 

  27. Nishimura RA, Hayes DL, Holmes DR Jr, Tajik AJ: Mechanism of hemodynamic improvement by dual-chamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study. J Am Coll Cardiol 1995, 25:281–288.

    Article  PubMed  CAS  Google Scholar 

  28. Linde C, Gadler F, Edner M, et al.: Results of atrioventricular synchronous pacing with optimized delay in patients with severe congestive heart failure. Am J Cardiol 1995, 75:919–923.

    Article  PubMed  CAS  Google Scholar 

  29. Auricchio A, Stellbrink C, Block M, et al.: Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation 1999, 99:2993–3001.

    PubMed  CAS  Google Scholar 

  30. Stockburger M, Fateh-Moghadam S, Nitardy A, et al.: Optimization of cardiac resynchronization guided by Doppler echocardiography: haemodynamic improvement and intraindividual variability with different pacing configurations and atrioventricular delays. Europace 2006, 8:881–886.

    Article  PubMed  Google Scholar 

  31. Hardt SE, Yazdi SH, Bauer A, et al.: Immediate and chronic effects of AV-delay optimization in patients with cardiac resynchronization therapy. Int J Cardiol 2007, 115:318–325.

    Article  PubMed  Google Scholar 

  32. Bordachar P, Lafitte S, Reuter S, et al.: Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing. J Am Coll Cardiol 2004, 44:2157–2165.

    Article  PubMed  Google Scholar 

  33. Abraham WT, Leon AR, Hannon C, et al.: Results of the InSync Marquis clinical trial. Heart Rhythm 2005, 2(15 Suppl):S65. Abstract AB 33-1.

    Google Scholar 

  34. Udelson JE, Konstam MA: Relation between left ventricular remodeling and clinical outcomes in heart failure patients with left ventricular systolic dysfunction. J Card Fail 2002, 8(6 Suppl):S465–S471.

    Article  PubMed  Google Scholar 

  35. Anand IS, Florea VG, Fisher L: Surrogate end points in heart failure. J Am Coll Cardiol 2002, 39:1414–1421.

    Article  PubMed  Google Scholar 

  36. Bleeker GB, Bax JJ, Fung JW, et al.: Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy. Am J Cardiol 2006, 97:260–263.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eugene S. Chung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mazur, W., Chung, E.S. The role of echocardiography in cardiac resynchronization therapy. Curr Heart Fail Rep 6, 37–43 (2009). https://doi.org/10.1007/s11897-009-0007-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11897-009-0007-7

Keywords

Navigation