Bjarnason I, MacPherson A, Hollander D: Intestinal permeability: an overview. Gastroenterology 1995, 108:1566–1581. A very comprehensive review of the topic of permeability covering the period up to 1995. Includes an extensive bibliography and a good presentation of experimental and clinical information.
Hollander D: Intestinal permeability in health and disease. In Inflammatory Bowel Disease, edn 5. Edited by Kirsenr JB and Hanauer S. Philadelphia: WB Saunders; 1999; in press. The most up-to-date review of the clinical issues and applications of intestinal permeability.
Madara JL, Pappenheimer JR: Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membrane Biol 1987, 100:149–164.
Menzies, I.S: Transmucosal passage of inert molecules in health and disease. In In Intestinal Absorption and Secretion, Falk symposium 36. Edited by Skadhauge E, Heintze K. Baltimore: University Park Press; 1983:527–543.
Hollander D: The intestinal permeability barrier: a hypothesis as to its regulation and involvement in Crohn’s disease. Scand J Gastroenterol 1992, 27:721–726. This article details the experimental background supporting the hypothesis that clinical permeability measurements reflect the state of the paracellular tight junctions.
Pearson ADJ, Eastham EJ, Laker MF, et al.: Intestinal permeability in children with Crohn’s disease and celiac disease. Br Med J 1982, 285:20–21.
Ukabam SO, Clamp JR, Cooper BT: Abnormal small intestinal permeability to sugars in patients with Crohn’s disease of the terminal ileum and colon. Digestion 1983, 27:70–74.
Hollander D, Vadheim CM, Brettholz E, et al.: Increased intestinal permeability in Crohn’s patients and their relatives: an etiological factor. Ann Int Med 1986, 105:883–885. This is the seminal report demonstrating permeability abnormalities in clinically normal blood relatives of patients with Crohn’s disease.
Katz KD, Hollander D, Vadheim CM, et al.: Intestinal permeability in patients with Crohn’s disease and their healthy relatives. Gastroenterology 1989, 97:927–931.
May GR, Sutherland LR, Meddings JB: Is small intestinal permeability really increased in relatives of patients with Crohn’s disease?
Gastroenterology 1993, 104:1627–1632.
Hollander D: Crohn’s disease: a permeability disorder of the tight-junction?
Gut 1988, 29:621–1624.
Hollander D: Permeability in Crohn’s disease: altered barrier functions in healthy relatives?
Gastroenterology 1993; 104:1848–1851.
Hollander D. The importance of intestinal permeability in the pathogenesis of Crohn’s disease. In Inflammatory Bowel Diseases, Falk Symposium 72. Edited by Rachmilewitz D. London: Kluwer Academic; 1994:41–51.
Pironi L, Miglioli M, Ruggeri E, et al.: Effect of non-steroidal anti-inflammatory drugs on intestinal permeability of first degree relatives of patients with Crohn’s disease [abstract]. Gastroenterology 1992, 102:A679.
Hilsden RJ, Meddings JB, Sutherland LR: Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn’s disease. Gastroenterology 1996, 110:1395–1403.
Peters M, Geypens B, Claus D, et al.: Clustering of increased small intestinal permeability in families with Crohn’s disease. Gastroenterology 1997,113:802–807.
Söderholm JD, Olaison G, Lindberg E, et al.: Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?
Gut 1999, 44:96–100. This recent paper demonstrates that aspirin preadministration can greatly clarify the genetic basis of permeability abnormalities in the relatives of patients with Crohn’s disease.
Anderson JM, Van Itallie CM: Tight junctions and molecular basis for regulation of paracellular permeability. Am J Physiol 1995, 269:467–475.
Lee VHL, Yamamoto A, Kompella VB: Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit Rev Ther Drug Carrier Syst 1991, 8:91–192.
Hochman J, Artursson P: Mechanisms of absorption enhancement and tight junction regulation. J Controlled Release 1994, 29:253–267.
Fasano A, Baudry B, Pumplin DW, et al.: Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci U S A 1991, 88:5242–5246.
Fasano A, Fiorentini C, Donelli G, et al.: Zonula Occludens Toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 1995, 96:710–720.
Fasano A, Uzzau S: Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest 1997, 99:158–164. An important demonstration of the therapeutic utility of manipulating the degree of permeability of the tight junctions.
Sanderson IR, Boulton P. Menzies IS, Walker-Smith JA: Improvement of abnormal lactulose/rhamnose permeability in active Crohn’s disease of the small bowel by an elemental diet. Gut 1987, 28:1073–1076.
Pironi L, Miglioli M, Ruggeri E, et al.: Relationship between intestinal permeability to 51Cr-EDTA and inflammatory activity in asymptomatic patients with Crohn’s disease. Dig Dis Sci 1990, 35:582–588.
Teahon K, Smethurst P, Pearson M, et al.: The effect of elemental diet on intestinal permeability and inflammation in Crohn’s disease. Gastroenterology 1991, 101:84–89.
Akram S, Morani S, Ou CN, et al.: Assessment of intestinal permeability with a two-hour urine collection. Dig Dis Sci 1998, 43:1946–1950.
Cox MA, Lewis KO, Cooper BT: Measurement of small intestinal permeability markers, lactulose, and mannitol in serum: results in celiac disease. Dig Dis Sci 1999, 44:402–406.
Wyatt J, Hubl W, Vogelsang H, Lochs H: Intestinal permeability predicts acute phases of Crohn’s disease [abstract]. Gastroenterology 1991, 100:A848.
Valpiani D, Ornigotti L, Ricca Rosellini S, et al.: Intestinal permeability: a non invasive method in predicting Crohn’s disease relapse [abstract]. Gastroenterology 1991, 100:A259.
Wyatt J, Vogelsang H, Hubl W, et al.: Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet 1993, 341:1437–1439.
Nejdfors P, Wang Q, Ekelund M, et al.: Increased colonic permeability in patients with ulcerative colitis: an in vitro study. Scand J Gastroenterol 1998, 33:749–753.
Miki K, Moore DJ, Butler RN, et al.: The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease. J Pediatr 1998, 133:750–754.
Pironi L, Miglioli M, Ruggeri E, et al.: Intestinal permeability (IP) to 51Cr-EDTA and postoperative recurrence of Crohn’s disease (CD): a follow-up study [abstract]. Gastroenterology 1991, 100:A239.
Krugliak P, Hollander D, Schlaepfer CC, et al.: Mechanisms and sites of mannitol permeability of small and large intestine in the rat. Dig Dis Sci 1994, 39:796–801.
Blomquist L, Oman H, Henriksson K, et al.: Increased absorption of polysucrose, a marker of intestinal paracellular permeability in Crohn’s disease. Eur J of Gastroenterol Hepatol 1993, 5:913–917.
Knight I: The development and applications of sucralose, a new high-intensity sweetener. Can J Physiol Pharmacol 1994, 72:435–439.
Meddings JB, Sutherland LR, Byles NI, Wallace JL: Sucrose: a novel permeability marker for gastroduodenal disease. Gastroenterology 1993, 104:1619–1626.
Jenkins AP, Nukajam WS, Menzies IS, Creamer B: Simultaneous administration of lactulose and 51Cr-ethylenediaminetetraacetic acid: a test to distinguish colonic from small-intestinal permeability change. Scand J Gastroenterol 1992, 27:769–773.
Bjarnason I, Peters TJ, Veall N: A persistent defect in intestinal permeability in celiac disease demonstrated by a [51Cr] labelled EDTA absorption test. Lancet 1983, 1(8336):1284–1285.
Ukabam SO, Cooper BT: Small intestinal permeability to mannitol, lactulose, and polyethylene glycol 400 in celiac disease. Dig Dis Sci 1984, 29:809–816.
Hamilton I, Cobden I, Axon ATR: Intestinal permeability in celiac disease: the response to gluten withdrawal and single dose gluten challenge. Gut 1982, 23:202–210.
Vogelsang H, Wyatt J, Penner E, et al.: Screening for celiac disease in first-degree relatives of patients with celiac disease by lactulose/mannitol test. Am J Gasteronenterol 1995, 90:1838–1842.
Bjarnason I, Peters TJ: Intestinal permeability, non-steroidal anti-inflammatory drug enteropathy and inflammatory bowel disease: an overview. Gut 1989, 30:22–28.
Bjarnason I, Haylar J. MacPherson AJ, Russell AS: Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993, 104:1832–1847.
Marcial MA, Carlson SL, Madara JL: Partitioning of paracellular conductance along the ileal and crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationship. J Membr Biol 1984, 80:59–70.
Harris CE, Griffiths RD, Freestone N, et al.: Intestinal permeability in the critically ill. Intensive Care Med 1992, 18:38–41.
Roumen RM, van der Vliet JA, et al.: Intestinal permeability is increased after major vascular surgery. J Vasc Surg 1993, 17:734–737.
Deitz EA: Intestinal permeability is increased in burn patients shortly after injury. Surgery 1990, 102:411–412.