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Zinc and intestinal function

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Abstract

Zinc is an abundant trace element in the human body that is essential for growth and development and immune function. It is important for the formation of biomembranes and zinc finger motifs found in DNA transcription factors and has catalytic function in metalloenzymes. The intestine is the site of zinc absorption and the major route of zinc excretion. Dietary inadequacy or conditions that decrease zinc absorption or increase its losses from the gastrointestinal tract, urine, or skin may quickly cause zinc deficiency due to the limited availability of rapidly exchangeable zinc pools in the body. Diarrhea is both a sign and a cause of zinc deficiency. The mechanism by which zinc deficiency causes diarrhea is not known. At this time, there is no readily available sensitive test for the detection of zinc deficiency, and therefore clinical suspicion remains the main mode of detection. In some individuals with diarrheal disease, zinc supplementation lessens diarrhea. Those receiving prolonged supplemental zinc therapy need to be monitored for copper deficiency.

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References and Recommended Reading

  1. Argiratos V, Samman S: The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects. Eur J Clin Nutr 1994, 45:198–204.

    Google Scholar 

  2. Snedeker SM, Smith SA, Greger JL: Effect of dietary calcium and phosphorous levels on the utilization of iron, copper, and zinc by adult males. J Nutr 1982, 112:136–143.

    PubMed  CAS  Google Scholar 

  3. McKenna AA, Ilich JZ, Andon MB, et al.:: Zinc balance in adolescent females consuming a low- or high-calcium diet. Am J Clin Nutr 1997, 65:1460–1464.

    PubMed  CAS  Google Scholar 

  4. Sandstrom B, Davidsson L, Cederblad A, et al.:: Oral iron, dietary ligands and zinc absorption. J Nutr 1985, 115:411–414.

    PubMed  CAS  Google Scholar 

  5. Valberg LS, Flanagan PR, Chamberlain MJ: Effects of iron, tin and copper on zinc absorption. Am J Clin Nutr 1984, 40:536–541.

    PubMed  CAS  Google Scholar 

  6. Turnlund JR, Durkin N, Costa F, et al.:: Stable isotope studies of zinc absorption and retention in young and elderly men. J Nutr 1986, 116:1239–1247.

    PubMed  CAS  Google Scholar 

  7. Gunshin H, Mackenzie B, Berger UV, et al.:: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388:482–488. This paper reports cloning and characterization of DCT1, the first mammalian divalent cation uptake process identified. DCT1 is upregulated by iron and shows substrate specificity for zinc as well as iron.

    Article  PubMed  CAS  Google Scholar 

  8. Reyes JG: Zinc transport in mammalian cells. Am J Physiol 1996, 270:C401–410.

    PubMed  CAS  Google Scholar 

  9. Palmiter RD, Findley SD: Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J 1995, 14:639–649.

    PubMed  CAS  Google Scholar 

  10. McMahon RJ, Cousins RJ: Regulation of the zinc transporter ZnT-1 by dietary zinc. Proc Natl Acad Sci U S A 1998, 95:4841–4846. The authors show that ZnT-1 is localized to the basolateral surface of intestinal villous epithelial cells using immunofluoresence. Whereas an oral load of zinc increased intestinal ZnT-1 mRNA levels, protein expression was not increased (the reverse was observed in liver tissues). Clearly, other factors are involved in the regulation of ZnT-1 transport proteins.

    Article  PubMed  CAS  Google Scholar 

  11. Palmiter RD, Cole TB, Findley SD: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J 1996, 15:1784–1791. These authors report on identification of a zinc transporter that is localized on intracellular vesicles. Using zinc-specific fluorescent probes, they demonstrated that ZnT-2 transports zinc into vesicles, thereby protecting transfected cells from toxicity.

    PubMed  CAS  Google Scholar 

  12. Foote JW, Delves HT: Albumin bound and alpha-2-macroglobulin bound zinc concentrations in the sera of healthy adults. J Clin Pathol 1984, 37:1050–1054.

    PubMed  CAS  Google Scholar 

  13. Wolman SL, Anderson G, Marliss EB, et al.:: Zinc in total parenteral nutrition: requirements and metabolic effects. Gastroenterology 1979, 76:458–467.

    PubMed  CAS  Google Scholar 

  14. Ruel MT, Rivera JA, Santizo M-C, et al.:: Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children. Pediatrics 1997, 99:808–813.

    Article  PubMed  CAS  Google Scholar 

  15. Hambidge KM: Zinc and diarrhea. Acta Paediatr Suppl 1992, 381:82–86.

    PubMed  CAS  Google Scholar 

  16. Sazawal S, Black RE, Bhan MK, et al.:: Zinc supplementation in young children with acute diarrhea in India. N Engl J Med 1995, 333:839–844. Report from a large study involving 937 children in India. The authors investigated the effect of zinc supplementation on acute diarrhea in this double-blinded, randomized, and controlled trial. All children also received oral rehydration solution and vitamin supplements. Dietary intakes were not measured.

    Article  PubMed  CAS  Google Scholar 

  17. Atherton DJ, Muller, DPR, Aggett, PJ, et al.:: A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica. Clin Sci (Lond) 1979, 56:505–507.

    CAS  Google Scholar 

  18. Piletz JE, Ganschow RE: Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Science 1978, 199:181–183.

    Article  PubMed  CAS  Google Scholar 

  19. Huang L, Gitschier J: A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet 1997, 17:292–297. The first identification of an inherited defect in a zinc-transport gene in mammals is reported here.

    Article  PubMed  CAS  Google Scholar 

  20. Walravens PA, Hambidge KM, Koepfer DM: Zinc supplementation in infants with a nutritional pattern of failure to thrive: a double-blind, controlled study. Pediatrics 1989, 83:532–538.

    PubMed  CAS  Google Scholar 

  21. Zarling EJ, Mobarhan S, Donahue PE: Does zinc deficiency affect intestinal protein content or disaccharidase activity? J Lab Clin Med 1985, 106:708–711.

    PubMed  CAS  Google Scholar 

  22. Moran JR, Lewis JC: The effects of severe zinc deficiency on intestinal permeability: an ultrastructural study. Pediatr Res 1985, 19:968–973.

    Article  PubMed  CAS  Google Scholar 

  23. Rodriguez P, Darmon N, Chappuis P, et al.:: Intestinal paracellular permeability during malnutrition in guinea pigs: effect of high dietary zinc. Gut 1996, 39:416–422.

    PubMed  CAS  Google Scholar 

  24. Ghishan FK: Transport of electrolytes, water and glucose in zinc deficiency. J Pediatr Gastroenterol Nutr 1984, 3:608–612.

    Article  PubMed  CAS  Google Scholar 

  25. Blanchard RK, Cousins RJ: Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am J Physiol 1997, 272:G972-G978. The authors identify zinc deficiency as the first known regulator of the hormone uroguanylin in rats.

    PubMed  CAS  Google Scholar 

  26. Fan X, Hamra FK, Freeman RH, et al.:: Uroguanylin: cloning of preprouroguanylin cDNA, mRNA expression in the intestine and heart and isolation of uroguanylin and prouroguanylin from plasma. Biochem Biophys Res Commun 1996, 219:457–462.

    Article  PubMed  CAS  Google Scholar 

  27. Hamra FK, Eber SL, Chin DT, et al.:: Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Proc Natl Acad Sci U S A 1997, 94:2705–2710.

    Article  PubMed  CAS  Google Scholar 

  28. Perkins A, Goy MF, Li Z: Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Gastroenterolgy 1997, 113:1007–1014.

    Article  CAS  Google Scholar 

  29. Kararskis EJ, Schuna A: Serum alkaline phsophatase after treatment of zinc deficiency in humans. Am J Clin Nutr 1980, 33:2609–2612.

    Google Scholar 

  30. Gordon W, White PJ: Zinc deficiency in total parenteral nutrition. S Afr Med J 1978, 54:823–824.

    Google Scholar 

  31. Festa MD, Anderson HL, Dowdy RP, et al: Effect of zinc intake on copper excretion and retention in men. Am J Clin Nutr 1985, 41:258–292.

    Google Scholar 

  32. Fosmire GM: Zinc toxicity. Am J Clin Nutr 1990,51:225–227.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Columbia University College of Physicians and Surgeons, Physicians and Surgeons Building, 10-508, 630 West 168th Street, 10032, New York, NY, USA

    Carol E. Semrad MD

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  1. Carol E. Semrad MD
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Semrad, C.E. Zinc and intestinal function. Curr Gastroenterol Rep 1, 398–403 (1999). https://doi.org/10.1007/s11894-999-0021-7

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  • DOI: https://doi.org/10.1007/s11894-999-0021-7

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