Barnes PM, Bloom B, Nahin R. CDC National Health Statistics Report #12. Complementary and alternative medicine use among adults and children: United States, 2007 2008 [cited 2019 April 20]. Available from: https://nccih.nih.gov/research/statistics/2007/camsurvey_fs1.htm. 20 April 2019
• Yoon SL, Grundmann O, Smith KF, Mason SR. Dietary supplement and complementary and alternative medicine use are highly prevalent in patients with gastrointestinal disorders: results from an online survey. J Diet Suppl. 2018;29:1–14. A recent internet-based survey revealed a high prevalence (84%) of use of dietary supplements and complementary and alternative medicine among respondents with a history of gastrointestinal symptoms.
Article
Google Scholar
Astin JA. Why patients use alternative medicine: results of a national study. Jama. 1998;279(19):1548–53.
CAS
PubMed
Article
Google Scholar
Hung A, Kang N, Bollom A, Wolf JL, Lembo A. Complementary and alternative medicine use is prevalent among patients with gastrointestinal diseases. Dig Dis Sci. 2015;60(7):1883–8.
PubMed
Article
Google Scholar
Vaezi MF, Yang YX, Howden CW. Complications of proton pump inhibitor therapy. Gastroenterology. 2017;153(1):35–48.
CAS
PubMed
Article
Google Scholar
El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014 Jun;63(6):871–80.
PubMed
Article
Google Scholar
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108(3):308–28 quiz 29.
PubMed
Article
Google Scholar
Ness-Jensen E, Hveem K, El-Serag H, Lagergren J. Lifestyle intervention in gastroesophageal reflux disease. Clin Gastroenterol Hepatol : the official clinical practice journal of the American Gastroenterological Association. 2016;14(2):175–82 e1–3.
Article
Google Scholar
Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166(9):965–71.
PubMed
Article
Google Scholar
Nebel OT, Fornes MF, Castell DO. Symptomatic gastroesophageal reflux: incidence and precipitating factors. Am J Dig Dis. 1976;21(11):953–6.
CAS
PubMed
Article
Google Scholar
Feldman M, Barnett C. Relationships between the acidity and osmolality of popular beverages and reported postprandial heartburn. Gastroenterology. 1995;108(1):125–31.
CAS
PubMed
Article
Google Scholar
Pointer SD, Rickstrew J, Slaughter JC, Vaezi MF, Silver HJ. Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: a pilot study in European- and African-American obese women. Aliment Pharmacol Ther. 2016;44(9):976–88.
CAS
PubMed
PubMed Central
Article
Google Scholar
Austin GL, Thiny MT, Westman EC, Yancy WS Jr, Shaheen NJ. A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms. Dig Dis Sci. 2006;51(8):1307–12.
CAS
PubMed
Article
Google Scholar
Morozov S, Isakov V, Konovalova M. Fiber-enriched diet helps to control symptoms and improves esophageal motility in patients with non-erosive gastroesophageal reflux disease. World J Gastroenterol. 2018;24(21):2291–9.
PubMed
PubMed Central
Article
Google Scholar
Gibson PR. History of the low FODMAP diet. J Gastroenterol Hepatol. 2017;32 Suppl 1:5–7.
PubMed
Article
Google Scholar
Nam SY, Park BJ, Cho YA, Ryu KH, Choi IJ, Park S, et al. Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects. J Gastroenterol. 2017;52(7):818–29.
CAS
PubMed
Article
Google Scholar
Mano F, Ikeda K, Sato T, Nakayama T, Tanaka D, Joo E, et al. Reduction in gastroesophageal reflux disease symptoms is associated with miso soup intake in a population-based cross-sectional study: the Nagahama study. J Nutr Sci Vitaminol. 2018;64(5):367–73.
CAS
PubMed
Article
Google Scholar
Nam SY, Park BJ, Cho YA, Ryu KH. Gender-specific effect of micronutrient on non-erosive reflux disease and erosive esophagitis. J Neurogastroenterol Motility. 2019;25(1):82–90.
Article
Google Scholar
Mano F, Ikeda K, Joo E, Yamane S, Harada N, Inagaki N. Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying. Nutrition. 2018;46:153–8 e1.
CAS
PubMed
Article
Google Scholar
Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc. 2005;105(7):1141–4.
PubMed
Article
Google Scholar
Johnston CS, White AM, Kent SM. A preliminary evaluation of the safety and tolerance of medicinally ingested vinegar in individuals with type 2 diabetes. J Med Food. 2008;11(1):179–83.
CAS
PubMed
Article
Google Scholar
Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol. 2007;20(7):46.
Article
Google Scholar
Petsiou EI, Mitrou PI, Raptis SA, Dimitriadis GD. Effect and mechanisms of action of vinegar on glucose metabolism, lipid profile, and body weight. Nutr Rev. 2014;72(10):651–61.
PubMed
Article
Google Scholar
Yagnik D, Serafin V, Shah AJ. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. Sci Rep. 2018;8(1):1732.
PubMed
PubMed Central
Article
Google Scholar
Brown R, Sam CH, Green T, Wood S. Effect of GutsyGum(tm), a novel gum, on subjective ratings of gastro esophageal reflux following a refluxogenic meal. J Diet Suppl. 2015;12(2):138–45.
CAS
PubMed
Article
Google Scholar
Yeh Z. Is apple cider vinegar effective for reducing heartburn symptoms related to gastroesophageal reflux disease?: Arizona State University; 2016.
Langella C, Naviglio D, Marino M, Calogero A, Gallo M. New food approaches to reduce and/or eliminate increased gastric acidity related to gastroesophageal pathologies. Nutrition. 2018;54:26–32.
CAS
PubMed
Article
Google Scholar
Kines K, Krupczak T. Nutritional interventions for gastroesophageal reflux, irritable bowel syndrome, and hypochlorhydria: a case report. Integr Med. 2016;15(4):49–53.
Google Scholar
Majka J, Wierdak M, Brzozowska I, Magierowski M, Szlachcic A, Wojcik D, et al. Melatonin in prevention of the sequence from reflux esophagitis to Barrett’s esophagus and esophageal adenocarcinoma: experimental and clinical perspectives. Int J Mol Sci. 2018;19(7):E2033.
PubMed
Article
Google Scholar
Kandil TS, Mousa AA, El-Gendy AA, Abbas AM. The potential therapeutic effect of melatonin in gastro-esophageal reflux disease. BMC Gastroenterol. 2010;10:7.
PubMed
PubMed Central
Article
Google Scholar
Pereira RD. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res. 2006;41(3):195–200.
CAS
Article
Google Scholar
• Hoshino N, Nishizaki D, Hida K, Obama K, Sakai Y. Rikkunshito for upper gastrointestinal symptoms: a systematic review and meta-analysis. Compl Ther Med. 2019;42:255–63. The results of a recent meta-analysis of 24 studies involving rikkunshito yielded mixed results, with significant relief of upper gastrointestinal symptoms demonstrated by a 5-point symptom score but not by the Gastrointestinal Symptom Rating Scale. Interpretation is limited generally by significant study heterogeneity and specifically by a lack of focus on esophageal symptoms primarily.
Article
Google Scholar
Tominaga K, Iwakiri R, Fujimoto K, Fujiwara Y, Tanaka M, Shimoyama Y, et al. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol. 2012;47(3):284–92.
CAS
PubMed
Article
Google Scholar
Tominaga K, Kato M, Takeda H, Shimoyama Y, Umegaki E, Iwakiri R, et al. A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study. J Gastroenterol. 2014;49(10):1392–405.
CAS
PubMed
Article
Google Scholar
Kawahara H, Kubota A, Hasegawa T, Okuyama H, Ueno T, Ida S, et al. Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. Pediatr Surg Int. 2007;23(10):1001–5.
PubMed
Article
Google Scholar
Yanai M, Mochiki E, Ogawa A, Morita H, Toyomasu Y, Ogata K, et al. Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs. J Gastroenterol. 2013;48(5):611–9.
PubMed
Article
Google Scholar
Melzer J, Rosch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther. 2004;20(11–12):1279–87.
CAS
PubMed
Article
Google Scholar
Abdel-Aziz H, Zaki HF, Neuhuber W, Kelber O, Weiser D, Khayyal MT. Effect of an herbal preparation, STW 5, in an acute model of reflux oesophagitis in rats. J Pharmacol Sci. 2010;113(2):134–42.
CAS
PubMed
Article
Google Scholar
Allescher HD, Abdel-Aziz H. Mechanism of action of STW 5 in functional dyspepsia and IBS: the origin of multi-target. Dig Dis. 2017;35(Suppl 1):18–24.
PubMed
Article
Google Scholar
Ottillinger B, Storr M, Malfertheiner P, Allescher HD. STW 5 (Iberogast(R))—a safe and effective standard in the treatment of functional gastrointestinal disorders. Wien Med Wochenschr. 2013;163(3–4):65–72.
PubMed
Article
Google Scholar
Teschke R, Frenzel C, Glass X, Schulze J, Eickhoff A. Greater Celandine hepatotoxicity: a clinical review. Ann Hepatol. 2012;11(6):838–48.
PubMed
Article
Google Scholar
Watts CR, Rousseau B. Slippery elm, its biochemistry, and use as a complementary and alternative treatment for laryngeal irritation. J Investig Biochem. 2010;1(1):17–23.
Article
Google Scholar
Yang Y, Wang S, Bao YR, Li TJ, Yang GL, Chang X, et al. Anti-ulcer effect and potential mechanism of licoflavone by regulating inflammation mediators and amino acid metabolism. J Ethnopharmacol. 2017;199:175–82.
CAS
PubMed
Article
Google Scholar
Albermann ME, Musshoff F, Hagemeier L, Madea B. Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality. Forensic Sci Int. 2010;197(1–3):35–9.
CAS
PubMed
Article
Google Scholar
Tewari SN, Trembalowicz FC. Some experience with deglycyrrhizinated liquorice in the treatment of gastric and duodenal ulcers with special reference to its spasmolytic effect. Gut. 1968;9(1):48–51.
CAS
PubMed
PubMed Central
Article
Google Scholar
Engqvist A, Von Feilitzen F, Pyk E, Reichard H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Gut. 1973;14(9):711–5.
CAS
PubMed
PubMed Central
Article
Google Scholar
Setright R. Prevention of symptoms of gastric irritation (GERD) using two herbal formulas: an observational study. J Austral Trad-Med Soc. 2017;23(2):68.
Google Scholar
Sewing KF. Efficacy of low-dose antacids in the treatment of peptic ulcers: pharmacological explanation? J Clin Gastroenterol. 1991;13(Suppl 1):S134–8.
PubMed
Article
Google Scholar
Young GP, Nagy GS, Myren J, Kronborg IJ, Logan KR, Reed PI, et al. Treatment of reflux oesophagitis with a carbenoxolone/antacid/alginate preparation. A double-blind controlled trial. Scand J Gastroenterol. 1986;21(9):1098–104.
CAS
PubMed
Article
Google Scholar
DiSilvestro RA, Verbruggen MA, Offutt EJ. Anti-heartburn effects of a fenugreek fiber product. Phytother Res : PTR. 2011;25(1):88–91.
CAS
PubMed
Article
Google Scholar
Ku SK, Seo BI, Park JH, Park GY, Seo YB, Kim JS, et al. Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity. World J Gastroenterol. 2009;15(38):4799–805.
PubMed
PubMed Central
Article
Google Scholar
Yarnell E, Abascal K. Herbs for gastroesophageal reflux disease. Alternative and Complementary Therapies. 2010;16(6):344–6.
Article
Google Scholar
Mittal RK, Holloway R, Dent J. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Gastroenterology. 1995;109(5):1547–54.
CAS
PubMed
Article
Google Scholar
Math MV, Khadkikar RM, Kattimani YR. Honey—a nutrient with medicinal property in reflux. Indian J Med Res. 2013;138(6):1020–1.
PubMed
PubMed Central
Google Scholar
Vemulapalli R. Diet and lifestyle modifications in the management of gastroesophageal reflux disease. Nutr Clin Pract : official publication of the American Society for Parenteral and Enteral Nutrition. 2008;23(3):293–8.
Article
Google Scholar
Eslick GD, Jones MP, Talley NJ. Non-cardiac chest pain: prevalence, risk factors, impact and consulting—a population-based study. Aliment Pharmacol Ther. 2003;17(9):1115–24.
CAS
PubMed
Article
Google Scholar
Fass R, Achem SR. Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motility. 2011;17(2):110–23.
Article
Google Scholar
Schey R, Villarreal A, Fass R. Noncardiac chest pain: current treatment. Gastroenterol Hepatol. 2007;3(4):255–62.
Google Scholar
Pimentel M, Bonorris GG, Chow EJ, Lin HC. Peppermint oil improves the manometric findings in diffuse esophageal spasm. J Clin Gastroenterol. 2001;33(1):27–31.
CAS
PubMed
Article
Google Scholar
• Khalaf MHG, Chowdhary S, Elmunzer BJ, Elias PS, Castell D. Impact of peppermint therapy on dysphagia and non-cardiac chest pain: a pilot study. Dig Dis Sci. 2019. A retrospective analysis of 36 patients treated with peppermint oil for dysphagia and/or non-cardiac chest pain found that 24 (63%) had symptom improvement. The presence of a well-defined esophageal motility disorder was associated with a relatively higher rate of symptom improvement.
Banovcin P, Duricek M, Zatko T, Liptak P, Hyrdel R, Kollarik M. The infusion of menthol into the esophagus evokes cold sensations in healthy subjects but induces heartburn in patients with gastroesophageal reflux disease (GERD). Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 2019.
Macpherson H, Dumville JC. Acupuncture as a potential treatment for non-cardiac chest pain—a survey. Acupunct Med: journal of the British Medical Acupuncture Society. 2007;25(1–2):18–21.
Article
Google Scholar
Dickman R, Schiff E, Holland A, Wright C, Sarela SR, Han B, et al. Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn. Aliment Pharmacol Ther. 2007;26(10):1333–44.
CAS
PubMed
Article
Google Scholar
Zhu J, Guo Y, Liu S, Su X, Li Y, Yang Y, et al. Acupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis. Acupunct Med : journal of the British Medical Acupuncture Society. 2017;35(5):316–23.
Article
Google Scholar
Arora AS, Katzka DA. How do I handle the patient with noncardiac chest pain? Clin Gastroenterol Hepatol : the official clinical practice journal of the American Gastroenterological Association. 2011;9(4):295–304 quiz e35.
Article
Google Scholar
Borjesson M, Pilhall M, Eliasson T, Norssell H, Mannheimer C, Rolny P. Esophageal visceral pain sensitivity: effects of TENS and correlation with manometric findings. Dig Dis Sci. 1998;43(8):1621–8.
CAS
PubMed
Article
Google Scholar