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Endoscopic Therapies for Gastroparesis

  • Stomach and Duodenum (J Pisegna and J Benhammou, Section Editors)
  • Published:
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Abstract

Purpose of Review

Gastroparesis remains a difficult-to-treat disease with limited therapeutic options. Though patients often have a common syndrome of stereotypic symptoms, the underlying pathophysiology is heterogeneous, often leading to variable treatment responses. Due to limitations in medical and surgical therapies, endoscopic options have been increasingly explored. These options can be broadly categorized into pyloric-directed therapy, non-pyloric-directed therapy, and nutritional support. In this review, we will highlight current and emerging endoscopic options, such as gastric per-oral endoscopic myotomy (G-POEM).

Recent Findings

Early retrospective studies on G-POEM offer encouraging results up to one year out, with an acceptable safety profile. Other pyloric-directed therapies, such as pyloric dilation and stenting, have also been explored.

Summary

While emerging endoscopic therapeutic options are encouraging, efficacy will likely depend on a better characterization of underlying pathophysiology and improved patient selection. Future prospective, controlled studies are needed.

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  1. Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2114, Los Angeles, CA, 90095, USA

    Andrew Su, Jeffrey L. Conklin & Alireza Sedarat

  2. Gastrointestinal Motor Function Laboratory, UCLA, Los Angeles, CA, USA

    Jeffrey L. Conklin

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Su, A., Conklin, J.L. & Sedarat, A. Endoscopic Therapies for Gastroparesis. Curr Gastroenterol Rep 20, 25 (2018). https://doi.org/10.1007/s11894-018-0630-0

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