The Microbiome That Shapes Us: Can It Cause Obesity?
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Purpose of Review
We sought to examine the effects of the gut microbial makeup on weight gain and obesity. We wanted to find out what the current research on this topic was and what the effect of the gut microbiota on energy metabolism is, as well the effects of diet on the microbiome and what effect the microbiome has on metabolic syndrome.
Obesity is thought to be due to greater calorie intake than expenditure. Recently, research has looked into the effects of the microbiome on obesity. Our gut flora is made up of trillions of microbes and there is evidence to suggest that even from the earliest stages of life, altering that flora can affect human’s ability to gain and lose weight, which can lead to obesity and ultimately other disease such as cardiovascular disease, diabetes mellitus, and liver disease.
Obesity can affect the human body in profound ways and lead to a multitude of comorbidities. We found that the obesity pandemic appears to parallel the increased use of antibiotics seen across the US. In addition, the use of antibiotics can alter the gut flora even from the earliest stages of life and the altered microbiome can alter our body habitus and energy metabolism through antibiotics, diet, and bariatric surgery.
KeywordsMicrobiota Antibiotic resistance Short-chain fatty acids Obesity Metabolic syndrome Lipopolysaccharides (LPS) Butyrate Cardiovascular disease Diabetes mellitus Non-alcoholic fatty liver disease (NAFLD)
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
- 1.•• Fukuda S, Ohno H. Gut microbiome and metabolic diseases. Semin Immunopathol. 2013;36(1):103–14. This paper provides a very good overall breakdown of the gut microbiome and how it can impact the development of obesity. It also discusses the microbiome’s ability to affect metabolic syndrome and other obesity-related diseases. CrossRefPubMedGoogle Scholar
- 2.World Health Organization. (2017). Obesity and overweight. [Online] Available at: http://www.who.int/mediacentre/factsheets/fs311/en/ [Accessed 23 July 2017].
- 4.Centers for Disease Control and Prevention. Adult Obesity Prevalence Maps, (2017). [Online Image] Available at: https://www.cdc.gov/obesity/data/prevalence-maps.html [Retrieved 13 July 2017]. Permission granted via email message 9/8/2017
- 10.•• Tremaroli V, Bäckhed F. Functional interactions between the gut microbiota and host metabolism. Nature. 2012;489(7415):242–9. Provides a good description of how the foods we eat get broken down and can affect our energy harvest. Also discusses how our diet can alter human gut microbiota. CrossRefPubMedGoogle Scholar
- 12.Blaut M. Simplified scheme showing the roles of SCFA in host metabolism. [Online image] In gut microbiota and energy balance: role in obesity. Proc Nutr Soc. 2014;74(03):230. Permission granted via email message 9/7/2017Google Scholar
- 16.Singh R, et al. “Impact of diet on the gut microbiome and human health.” [Online image] In influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(73):3. Permission granted online 9/7/2017Google Scholar
- 19.Eid N, Enani S, Walton G, Corona G, Costabile A, Gibson G, et al. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci. 2014;3(46):1–9.Google Scholar