Abstract
Malnutrition is associated with alcoholic liver disease (ALD) and related complications such as hepatic encephalopathy and increased rate of infections. Avoidance of prolonged fasting and overly restrictive diets is important to avoid poor nutrition. Adequate intake of calories, protein, and micronutrients via frequent small meals and evening supplements and/or enteral and parenteral nutrition when indicated has been associated with reduced mortality and morbidity in patients with ALD. Modification of protein/fat sources and composition in addition to probiotic supplementation are promising interventions for decreased progression of ALD and its complications.
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References
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Rossi RE, Conte D, Massironi S. Diagnosis and treatment of nutritional deficiencies in alcoholic liver disease: overview of available evidence and open issues. Dig Liver Dis. 2015;47(10):819–25.
Patek AJ. Alcohol, malnutrition, and alcoholic cirrhosis. Am J Clin Nutr. 1979;32:1304–12.
Iwasa M, Iwata K, Hara N, Hattori A, Ishidome M, Sekoguchi-Fujikawa N, et al. Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis. Nutrition. 2013;29(11–12):1418–21.
O’Shea RS, Srinivasan D, McCullough AJ. Alcoholic liver disease. Hepatology. 2010;51:307–28.
Plauth M, Cabré E, Riggio O, Assis-Camilo M, Pirlich M, Kondrup J, et al. ESPEN guidelines on enteral nutrition: liver disease. Clin Nutr. 2006;25:285–94.
••Fialla AD, Israelsen M, Hamberg O, Krag A, Gluud LL. Nutritional therapy in cirrhosis or alcoholic hepatitis: a systematic review and meta-analysis. Liver Int. 2015;35(9):2072–8. This systematic review and meta-analysis included 13 randomized controlled trials evaluating the effects of enteral and intravenous nutrition therapy vs. no intervention in patients with cirrhosis or alcoholic hepatitis and suggests that nutrition therapy can lead to reduced mortality, overt encephalopathy and infection.
Koretz RL, Avenell A, Lipman TO. Nutritional support for liver disease. Cochrane Database Syst Rev. 2012;5:CD008344.
Ney M, Vandermeer B, van Zanten SJ, Ma MM, Gramlich L, Tandon P. Meta-analysis: oral or enteral nutritional supplementation in cirrhosis. Aliment Pharmacol Ther. 2013;37(7):672–9.
Krenitsky J. Nutrition update in hepatic failure. Nutrition issues in gastroenterology, series #128. Practical Gastroenterology [Internet]. 2014 apr [47–55]. Available from: http://www.medicine.virginia.
Roe DA. Nutritional concerns in the alcoholic. J Am Diet Assoc. 1981;78(1):17–21.
Mendenhall CL, Roselle GA, Gartside P, Moritz T. Relationship of protein calorie malnutrition to alcoholic liver disease: a reexamination of data from two Veterans Administration Cooperative Studies. Alcohol Clin Exp Res. 1995;19(3):635–41.
Marsano L, McClain CJ. Nutrition and alcoholic liver disease. JPEN J Parenter Enteral Nutr. 1991;15(3):337–44.
Mendenhall CL, Anderson S, Weesner RE, Goldberg SJ, Crolic KA. Protein-calorie malnutrition associated with alcoholic hepatitis. Veterans Administration Cooperative Study Group on Alcoholic Hepatitis. Am J Med. 1984;76:211–22.
Singal AK, Kamath PS, Francisco Ziller N, DiCecco S, Shoreibah M, Kremers W, et al. Nutritional status of patients with alcoholic cirrhosis undergoing liver transplantation: time trends and impact on survival. Transpl Int. 2013;26(8):788–94.
Hade AM, Shine AM, Kennedy NP, McCormick PA. Both under-nutrition and obesity increase morbidity following liver transplantation. Ir Med J. 2003;96:140.
Figueiredo F, Dickson ER, Pasha T, et al. Impact of nutritional status on outcomes after liver transplantation. Transplantation. 2000;70:1347.
Shahid M, Johnson J, Nightingale P, Neuberger J. Nutritional markers in liver allograft recipients. Transplantation. 2005;79:359.
Spengler EK, Dunkelberg J, Schey R. Alcoholic hepatitis: current management. Dig Dis Sci. 2014;59:2357–66.
Liu Y, Xue X. Systematic review of peri-operative nutritional support for patients undergoing hepatobiliary surgery. Hepatobiliary Surg Nutr. 2015;4(5):304–12.
DiCecco SR, Francisco-Ziller N. Nutrition in alcoholic liver disease. Nutr Clin Pract. 2006;21(3):245–54.
Halsted CH. Nutrition and alcoholic liver disease. Semin Liver Dis. 2004;24:289–304.
Losowsky MS, Walker BE. Liver disease and malabsorption. Gastroenterology. 1969;56:589–600.
Halsted CH, Robles EA, Mezey E. Intestinal malabsorption in folate deficient alcoholics. Gastroenterology. 1973;64:526–32.
Mezey E, Jow E, Slavin RE, et al. Pancreatic function and intestinal absorption in chronic alcoholism. Gastroenterology. 1970;59:657.
Arky RA. The effect of alcohol on carbohydrate metabolism: carbohydrate metabolism in alcoholics. In: Kissin B, Begleiter H, editors. The biology of alcoholism, vol. 1. New York: Plenum Press; 1977. p. 197.
Israel Y, Salazar I, Rosenmann E, et al. Inhibitory effects of alcohol on intestinal acid transport in vivo and in vitro. J Nutr. 1968;96:499.
Muller MJ, Lautz HU, Plogmann B, Burger M, Korber J, Schmidt FW. Energy expenditure and substrate oxidation in patients with cirrhosis: the impact of cause, clinical staging and nutritional state. Hepatology. 1992;15:782–94.
Israel Y, Videla L, Bernstein J. Liver hypermetabolic state after chronic ethanol consumption: hormonal interrelations and pathogenic implications. Fed Proc. 1975;34:2052–9.
Jhangiani SS, Agarwal N, Holmes R, et al. Energy expenditure in chronic alcoholics with and without liver disease. Am J Clin Nutr. 1986;44:323–9.
Pirola RC, Lieber CS. Hypothesis: energy wasting in alcoholism and drug abuse: possible role of hepatic microsomal enzymes. Am J Clin Nutr. 1976;29:90.
Amodio P et al. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. Hepatology. 2013;58(1):325–36.
Singal AK, Charlton MR. Nutrition in alcoholic liver disease. Clin Liver Dis. 2012;16(4):805–26.
Purnak T, Yilmaz Y. Liver disease and malnutrition. Best Pract Res Clin Gastroenterol. 2013;27(4):619–29.
Rothschild MA, Oratz M, Schreiber SS. Serum albumin. Hepatology. 1988;8(2):385–401.
Matos C et al. Nutrition and chronic liver disease. J Clin Gastroenterol. 2002;35(5):391–7.
Moctezuma-Velazquez C et al. Nutritional assessment and treatment of patients with liver cirrhosis. Nutrition. 2013;29(11–12):1279–85.
Frisancho AR. New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr. 1981;34(11):2540–5.
Romeiro FG, Augusti L. Nutritional assessment in cirrhotic patients with hepatic encephalopathy. World J Hepatol. 2015;7(30):2940–54.
Selberg O, Selberg D. Norms and correlates of bioimpedance phase angle in healthy human subjects, hospitalized patients, and patients with liver cirrhosis. Eur J Appl Physiol. 2002;86(6):509–16.
Kohrt WM. Body composition by DXA: tried and true? Med Sci Sports Exerc. 1995;27(10):1349–53.
Madden AM, Morgan MY. The potential role of dual-energy X-ray absorptiometry in the assessment of body composition in cirrhotic patients. Nutrition. 1997;13(1):40–5.
Alvares-da-Silva MR, Reverbel da Silveira T. Comparison between handgrip strength, subjective global assessment, and prognostic nutritional index in assessing malnutrition and predicting clinical outcome in cirrhotic outpatients. Nutrition. 2005;21(2):113–7.
John WJ, Phillips R, Ott L, Adams LJ, McClain CJ. Resting energy expenditure in patients with alcoholic hepatitis. JPEN J Parenter Enteral Nutr. 1989;13(2):124–7.
Dugum M, McCullough A. Diagnosis and management of alcoholic liver disease. J Clin Transl Hepatol. 2015;3(2):109–16.
Mouzaki M, Ng V, Kamath BM, Selzner N, Pencharz P, Ling SC. Enteral energy and macronutrients in end-stage liver disease. JPEN J Parenter Enteral Nutr. 2014;38(6):673–81.
McClain CJ et al. Alcoholic liver disease and malnutrition. Alcohol Clin Exp Res. 2011;35(5):815–20.
Manne V, Saab S. Impact of nutrition and obesity on chronic liver disease. Clin Liver Dis. 2014;18(1):205–18.
Leevy CM, Moroianu SA. Nutritional aspects of alcoholic liver disease. Clin Liver Dis. 2005;9:67–81.
Roongpisuthipong C, Sobhonslidsuk A, Nantiruj K, Songchitsomboon S. Nutritional assessment in various stages of liver cirrhosis. Nutrition. 2001;17:761–5.
Medici V, Peerson JM, Stabler SP. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol. 2010;53:551–7.
Fragasso A et al. Holotranscobalamin is a useful marker of vitamin B12 deficiency in alcoholics. Sci World J. 2012;2012:128182.
de Carvalho SC et al. Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD). Nutr J. 2013;12:37.
Medici V, Halsted CH. Folate, alcohol, and liver disease. Mol Nutr Food Res. 2013;57(4):596–606.
Herbert V, Zalusky R, Davidson CS. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease. Ann Intern Med. 1963;58:977–88.
Fernando OV, Grimsley EW. Prevalence of folate deficiency and macrocytosis in patients with and without alcohol-related illness. South Med J. 1998;91(8):721–5.
Halsted CH et al. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A. 2002;99(15):10072–7.
Halsted CH et al. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 1996;23(3):497–505.
Wani NA, Kaur J. Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism. J Cell Physiol. 2011;226(3):579–87.
Eichner ER, Hillman RS. The evolution of anemia in alcoholic patients. Am J Med. 1971;50(2):218–32.
Williams JA, Manley S, Ding WX. New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol. 2014;20(36):12908–33.
Friedrich K, Baumann C, Brune M, Wannhoff A, Rupp C, Scholl SG, et al. Association of serum zinc levels with liver function and survival in patients awaiting liver transplantation. Langenbeck’s Arch Surg. 2015;400(7):805–11.
••Mohammad MK, Falkner KC, Song M, Craig J, McClain CJ, Cave MC. Low dose zinc sulfate (220mg) supplementation for three months normalizes zinc levels, endotoxeima, pro-inflammatory/fibrotic biomarkers & improves clinical parameters in alcoholic cirrhosis- a double-blind placebo controlled - (ZAC) clinical trial. Hepatology. 2015;62:851A. This single center double blind placebo controlled trial is the first to provide evidence for the safety and efficacy of zinc supplementation for improvement of endotoxemia, inflammatory biomarkers and clinical status in patients with alcoholic cirrhosis.
Wiegand J, van Bömmel F, Duarte-Rojo A, Altamirano J, Abraldes JG, Villanueva A, et al. Clinical trial watch: reports from the liver meeting®, AASLD, San Francisco, November 2015. J Hepatol. 2016;64(6):1428–45.
•Bémeur C, Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications. J Clin Exp Hepatol. 2014;4(2):141–50. This review summarizes the nutritional deficiencies commonly encountered in chronic liver disease and the impact that malnutrition can have on disease outcome, incidence and severity of complications such as hepatic and Wernicke’s encephalopathy and post-transplant mortality and morbidity.
Anastácio LR, Correia MITD. Nutrition therapy: integral part of liver transplant care. World J Gastroenterol. 2016;22(4):1513.
Kim MS, Ong M, Qu X. Optimal management for alcoholic liver disease: conventional medications, natural therapy or combination? World J Gastroenterol. 2016;22(1):8–23.
Bruha R, Dvorak K, Petrtyl J. Alcoholic liver disease. World J Hepatol. 2012;4(3):81–90.
Chayanupatkul M, Liangpunsakul S. Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment. World J Gastroenterol. 2014;20(20):6279–86.
Tsien CD, McCullough AJ, Dasarathy S. Late evening snack: exploiting a period of anabolic opportunity in cirrhosis. J Gastroenterol Hepatol. 2012;27(3):430–41.
Kirpich IA, Miller ME, Cave MC, Joshi-Barve S, McClain CJ. Alcoholic liver disease: update on the role of dietary fat. Biomolecules. 2016;6(1):1.
•Wang Y, Liu Y, Kirpich I, Ma Z, Wang C, Zhang M, et al. Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury. J Nutr Biochem. 2013;24(9):1609–15. This animal study evaluated the effects of probiotic administration on hepatic epatic tumor necrosis factor-α (TNFα) production and inflammation in response to chronic alcohol ingestion in mice. The results demonstrated that probiotic Lactobacillus rhamnosus GG treatment reduced alcohol-induced hepatic inflammation by attenuating TNFα production by inhibiting TLR4 and TLR5-mediated intestinal gram-negative bacterial endotoxin activation.
Huynh DK, Selvanderan SP, Harley HA, Holloway RH, Nguyen NQ. Nutritional care in hospitalized patients with chronic liver disease. World J Gastroenterol. 2015;21(45):12835–42.
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, et al. Prednisolone or pentoxifylline for aloholic hepatitis. N Engl J Med. 2015;372(17):1619–28.
Hébuterne X, Vanbiervliet G. Feeding the patients with upper gastrointestinal bleeding. Curr Opin Clin Nutr Metab Care. 2011;14(2):197–201.
•Cabré E, Rodríguez-Iglesias P, Caballería J, Quer JC, Sán-chez-Lombraña JL, Parés A, et al. Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multi-center randomized trial. Hepatology. 2000;32:3–42. This multicenter randomized compared the short and long term effects of total enteral nutrition vs. steroid therapy for 28 days in severe alcoholic hepatitis. Mortality was similar for both those treated with nutritional therapy and those treated with steroids during therapy, but occurred earlier in those treated with nutritional therapy. However, overall mortality at 1 year was higher in the group treated with steroids largely due to infection.
Papastergiou V, Burroughs AK, Tsochatzis EA. Prognosis and treatment of patients with acute alcoholic hepatitis. Expert Rev Gastroenterol Hepatol. 2014;8:471–86.
Moreno C, Deltenre P, Senterre C, Louvet A, Gustot T, Bastens B, et al. Intensive enteral nutrition is ineffective for patients with severe alcoholic hepatitis treated with corticosteroids. Gastroenterology. 2016;150(4):903–910.e8.
Figueira ERR, Rocha Filho JA, Nacif LS, D’Albuquerque LC, Waitzberg DL. Nutritional support for fulminant hepatitis. Nutr Hosp. 2015;32(n06):2427–32.
Metcalfe EL, Avenell A, Fraser A. Branched-chain amino acid supplementation in adults with cirrhosis and porto-systemic encephalopathy: systematic review. Clin Nutr. 2014;33:958–65.
Gluud LL, Dam G, Les I, Córdoba J, Marchesini G, Borre M, et al. Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2015;9:CD001939.
Irimia R, Stanciu C, Cojocariu C, Sfarti C, Trifan A. Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. J Gastrointestin Liver Dis. 2013;22(3):277–81.
Hammad A, Kaido T, Uemoto S. Perioperative nutritional therapy in liver transplantation. Surg Today. 2015;45:271–83.
Zhu X, Wu Y, Qiu Y, Jiang C, Ding Y. Effects of ω-3 fish oil lipid emulsion combined with parenteral nutrition on patients undergoing liver transplantation. JPEN J Parenter Enteral Nutr. 2013;37:68–74.
Puri P, Thursz M. Intensive enteral nutrition in alcoholic hepatitis: more food for thought. Gastroenterology. 2016;150(4):803–5.
Kumar M, Panda D. Role of supportive care for terminal stage hepatocellular carcinoma. J Clin Exp Hepatol. 2014;4 Suppl 3:S130–9.
Mifflin MD et al. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr. 1990;51(2):241–7.
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Drs. Chao, Waitzberg, Passos de Jesus, Bueno, Kha, Allen, Kappus, and Medici declare no conflict of interest.
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Chao, A., Waitzberg, D., de Jesus, R.P. et al. Malnutrition and Nutritional Support in Alcoholic Liver Disease: a Review. Curr Gastroenterol Rep 18, 65 (2016). https://doi.org/10.1007/s11894-016-0539-4
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DOI: https://doi.org/10.1007/s11894-016-0539-4
Keywords
- Alcoholic liver disease
- Diet
- Nutrition
- Enteral nutrition
- Parenteral nutrition