The Paradox of Artificial Sweeteners in Managing Obesity

Nutrition and Obesity (S McClave, Section Editor)

DOI: 10.1007/s11894-014-0423-z

Cite this article as:
Roberts, J.R. Curr Gastroenterol Rep (2015) 17: 1. doi:10.1007/s11894-014-0423-z
Part of the following topical collections:
  1. Topical Collection on Nutrition and Obesity


The role of artificial sweeteners in the management of obesity is controversial. Observational data have suggested that nonnutritive sweeteners (NNSs) may promote weight gain through poorly understood mechanisms of cravings, reward phenomenon, and addictive behavior via opioid receptors. Interventional studies suggest the opposite that substitution of NNS for sugar-sweetened beverages (SSBs) results in reduced caloric intake and modest degrees of weight loss. Whether the use of NNS provides benefit toward weight reduction in the individual patient may depend on the characteristics of their baseline diet, associated changes, or dietary compensation involved with ingestion of NNS, and the degree of compliance with a more complete weight loss program.


Artificial sweeteners Obesity Sugar substitutes 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Louisville School of MedicineLouisvilleUSA
  2. 2.Division of Gastroenterology, Hepatology and NutritionUniversity of Louisville School of MedicineLouisvilleUSA

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