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The Pharmacologic Treatment of Short Bowel Syndrome: New Tricks and Novel Agents

  • Nutrition and Obesity (SA McClave, Section Editor)
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Abstract

Short bowel syndrome (SBS) is a manifestation of massive resection of the intestines resulting in severe fluid, electrolyte, and vitamin/mineral deficiencies. Diet and parenteral nutrition play a large role in the management of SBS; however, pharmacologic options are becoming more readily available. These pharmacologic agents focus on reducing secretions and stimulating intestinal adaptation. The choice of medication is highly dependent on the patient’s symptoms, remaining anatomy, and risk versus benefit profile for each agent. This article focuses on common and novel pharmacologic medications used in SBS, including expert advice on their indications and use.

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Conflict of Interest

Matthew L. Bechtold is a consultant for Nestle. Lena B. Palmer, Douglas L. Nguyen, Lindsay M. Urben, Robert G. Martindale, and Ryan T. Hurt have nothing to disclose.

Steven A. McClave is a consultant for Covidien and has received research grants from Abbot and Nestle.

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Authors and Affiliations

  1. Departments of Medicine, University of Missouri, Columbia, MO, USA

    Matthew L. Bechtold

  2. University of Louisville School of Medicine, Louisville, KY, USA

    Stephen A. McClave & Ryan T. Hurt

  3. Loyola University, Chicago, IL, USA

    Lena B. Palmer

  4. University of California, Irvine, CA, USA

    Douglas L. Nguyen

  5. Department of Pharmacy, University of Louisville School of Medicine, Louisville, KY, USA

    Lindsay M. Urben

  6. Department of Surgery, Oregon Health Sciences University, Portland, OR, USA

    Robert G. Martindale

  7. Divisions of General Internal Medicine, Mayo Clinic, Rochester, MN, USA

    Ryan T. Hurt

  8. Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA

    Ryan T. Hurt

  9. Endocrinology, Mayo Clinic, Rochester, MN, USA

    Ryan T. Hurt

  10. Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville School of Medicine, Louisville, KY, 40202, USA

    Stephen A. McClave

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  1. Matthew L. Bechtold
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Correspondence to Stephen A. McClave.

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Bechtold, M.L., McClave, S.A., Palmer, L.B. et al. The Pharmacologic Treatment of Short Bowel Syndrome: New Tricks and Novel Agents. Curr Gastroenterol Rep 16, 392 (2014). https://doi.org/10.1007/s11894-014-0392-2

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