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Endoscopic Submucosal Dissection for Malignant Esophageal Lesions

  • Esophagus (L Gerson, Section Editor)
  • Published:
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Abstract

The incidence of esophageal cancer has been increasing while the prognosis remains very poor. Endoscopic submucosal dissection (ESD) was developed in Japan for en bloc resection of early gastric cancer with excellent results. The use of ESD in early squamous cell cancer (SCC) of the esophagus in Japan has been increasing with long-term results comparable to those in early gastric cancer. The use of ESD in Barrett’s neoplasia in western countries has been challenged by the low complete resection rates and the risk of metachronous lesions from surrounding non-dysplastic Barrett’s epithelium. Efforts to combine ESD with other treatment modalities such as radiofrequency ablation in Barrett’s neoplasia and chemoradiation in SCC appear to be promising. The use of steroid therapy (local or systemic) has been demonstrated to prevent post-ESD stenosis, which is the most common complication after esophageal ESD.

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Abbreviations

SCC:

Squamous cell carcinoma

EMR:

Endoscopic mucosal resection

ESD:

Endoscopic submucosal dissection

NCCN:

National Comprehensive Cancer Network

EGJ:

Esophago-gastric junction

CRT:

Chemoradiation therapy

ESTD:

Endoscopic submucosal tunnel dissection

IPCL:

Intraepithelial papillary capillary loops

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Conflict of Interest

Dr. Hammad has nothing to disclose.

Dr. Kaltenbach and Dr. Soetikno report grants from Olympus America outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Harry S. Truman Memorial Veterans Hospital, University of Missouri Hospital and Clinics, Columbia, MO, USA

    Hazem Hammad

  2. Veterans Affairs Palo Alto, Stanford University School of Medicine, Palo Alto, CA, USA

    Tonya Kaltenbach & Roy Soetikno

  3. Division of Gastroenterology, University of Missouri Hospital and Clinics, Five Hospital Drive, Columbia, MO, 65212, USA

    Hazem Hammad

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  1. Hazem Hammad
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  2. Tonya Kaltenbach
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  3. Roy Soetikno
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Correspondence to Hazem Hammad.

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This article is part of the Topical Collection on Esophagus

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Hammad, H., Kaltenbach, T. & Soetikno, R. Endoscopic Submucosal Dissection for Malignant Esophageal Lesions. Curr Gastroenterol Rep 16, 386 (2014). https://doi.org/10.1007/s11894-014-0386-0

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