Infant GERD: Symptoms, Reflux Episodes & Reflux Disease, Acid & Non-acid Refllux—Implications for Treatment with PPIs

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References

  1. 1.

    Davidson G, Wenzl TG, Thomson M, Omari T, Barker P, Lundborg P, et al. Efficacy and safety of once-daily esomeprazole for the treatment of gastroesophageal reflux disease in neonatal patients. J Pediatr. 2013. doi:10.1016/j.jpeds.2013.05.007.

    PubMed  Google Scholar 

  2. 2.

    Orenstein SR. Crying in infant GERD: acid or volume? Heartburn or dyspepsia? Curr Gastro Rep. 2008;10:433–6.

    Article  Google Scholar 

  3. 3.

    Neuhauser EBD, Berenberg W. Cardio-esophageal relaxation as a cause of vomiting in infants. Radiology. 1947;48(5):480–3.

    PubMed  CAS  Google Scholar 

  4. 4.

    Astley R, Carre IJ. Gastro-oesophageal incompetence in children. Radiology. 1954;62:351–62.

    PubMed  CAS  Google Scholar 

  5. 5.

    Ament ME, Christie DL. Upper gastrointestingal fiberoptic endoscopy in pediatric patients. Gastroenterology. 1977;72(6):1244–8.

    PubMed  CAS  Google Scholar 

  6. 6.

    Black DD, Haggitt RC, Orenstein SR, Whitington PF. Esophagitis in infants: morphometric histological diagnosis and correlation with measures of gastroesophageal reflux. Gastroenterology. 1990;98(6):1408–14.

    PubMed  CAS  Google Scholar 

  7. 7.

    Orenstein SR, Shalaby TM, Kelsey SF, Frankel E. Natural history of infant reflux esophagitis: symptoms and morphometric histology during one year without pharmacotherapy. Am J Gastroenterol. 2006;101:628–40.

    PubMed  Article  Google Scholar 

  8. 8.

    Sondheimer JM. Continuous monitoring of distal esophageal pH: a diagnostic test for gastroesophageal reflux in infants. J Pediatr. 1980;96(5):804–7.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Vandenplas Y, Sacre-Smits L. Continuous 24-hour esophageal pH monitoring in 285 asymptomatic infants 0-15 months old. J Pediatr Gastroenterol Nutr. 1987;6:220–4.

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Cucchiara S, Staiano A, Gobio Casali L, Boccieri A, Paone FM. Value of the 24 hour intraoesophageal pH monitoring in children. Gut. 1990;31:129–33.

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Vandenplas Y, Loeb H. The interpretation of oesophageal pH monitoring data. Eur J Pediatri. 1990;149(9):598–602.

    Article  CAS  Google Scholar 

  12. 12.

    Jolley SG, Herbst JJ, Johnson DG, Matlak ME, Book LS. Esophageal pH monitoring during sleep identifies children with respiratory symptoms from gastroesophageal reflux. Gastroenterology. 1981;80(6):1501–6.

    PubMed  CAS  Google Scholar 

  13. 13.

    Wenzl TG, Schenke S, Peschgens T, Silny J, Heimann G, Skopnik H. Association of apnea and nonacid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol. 2001;31:144–9.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Rosen R, Nurko S. The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms. Am J Gastroenterol. 2004;99:2452–8.

    PubMed  Article  Google Scholar 

  15. 15.

    Rosen R, Lord C, Nurko S. The sensitivity of multichannel intraluminal impedance and the pH probe in the evaluation of gastroesophageal reflux in children. Clin Gastroenterol Hepatol. 2006;4:167–72.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Feranchak AP, Orenstein SR, Cohn JF. Behaviors associated with onset of gastroesophageal reflux episodes in infants: prospective study using split-screen video and pH probe. Clin Pediatr. 1994;33(11):654–62.

    Article  CAS  Google Scholar 

  17. 17.

    Snel A, Barnett CP, Cresp TL, Haslam RR, Davidson GP, Malbert CH, et al. Behavior and gastroesophageal reflux in the premature neonate. J Pediatr Gastroenterol Nutr. 2000;30(1):18–21.

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Pellegrini CA, DeMeester TR, Johnson LF, Skinner DB. Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. Surgery. 1979;86(1):110–9.

    PubMed  CAS  Google Scholar 

  19. 19.

    Barr RG. The normal crying curve: what do we really know? Developmental Medicine & Child Neurology. 1990;32(4):356–62.

    Article  CAS  Google Scholar 

  20. 20.

    Sintonen H. Outcome measurement in acid-related diseases. Pharmaco Economics. 1994;5(Supp3):17–26.

    Article  Google Scholar 

  21. 21.

    Kleinman L, Revicki DA, Flood E. Validation issues in questionnaires for diagnosis and monitoring of gastroesophageal reflux disease in children. Curr Gastroenterol Rep. 2006;8(3):230–6.

    PubMed  Article  Google Scholar 

  22. 22.

    Nimish V, van Zanten SV, Kahrilas P, Dent J, Jones R. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.

    Article  Google Scholar 

  23. 23.

    Sherman PM, Hassall E, Fagundes-Neto U, Gold BD, Kato S, Koletzko S, et al. A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population. Am J Gastroenterol. 2009;104:1278–95.

    PubMed  Article  Google Scholar 

  24. 24.

    Orenstein SR, Shalaby TM, Cohn JF. Reflux symptoms in 100 normal infants: diagnostic validity of the infant gastroesophageal reflux questionnaire. Clin Pediatr. 1996;35:607.

    Article  CAS  Google Scholar 

  25. 25.

    Orenstein SR, Cohn JF, Shalaby TM, Kartan R. Reliability and validity of an infant gastroesophageal reflux questionnaire. Clin Pediatr. 1993;32:472–84.

    Article  CAS  Google Scholar 

  26. 26.

    Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during infancy: a pediatric practice-based survey. Arch Pediatr Adolesc Med. 1997;151(6):569–72.

    PubMed  Article  CAS  Google Scholar 

  27. 27.

    Deal L, Gold BD, Gremse DA, et al. Age-specific questionnaires distinguish GERD symptom frequency in infants and young children: development and initial validation. J Pediatr Gastroenterol Nutr. 2005;41:178–85.

    PubMed  Article  Google Scholar 

  28. 28.

    Kleinman L, Rothman M, Strauss R, Orenstein SR, Nelson S, Vandenplas Y, et al. The infant gastroesophageal reflux questionnaire revised: development and validation as an evaluative instrument. Clin Gastroenterol Hepatol. 2006;4:588–96.

    PubMed  Article  Google Scholar 

  29. 29.

    Kleinman L, Nelson S, Kothari-Talwar S, Roberts L, Orenstein SR, Mody RR, et al. Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire. J Pediatr Gastroenterol Nutr. 2011;52:514–22.

    PubMed  Article  Google Scholar 

  30. 30.

    Shalaby TM, Orenstein SR. Efficacy of telephone teaching of conservative therapy for infants with symptomatic gastroesophageal reflux referred by pediatricians to pediatric gastroenterologists. J Pediatr. 2003;142:57–61.

    PubMed  Article  Google Scholar 

  31. 31.

    Orenstein SR, McGowan JD. Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux. J Pediatr. 2008;152:310–4.

    PubMed  Article  Google Scholar 

  32. 32.

    Orenstein SR, Hassall E, Furmaga-Jablonska W, Atkinson S, Raanan M. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease. J Pediatr. 2009;154:514–20.

    PubMed  Article  CAS  Google Scholar 

  33. 33.

    Moore DJ, Tao BS-K, Lines DR, Hirte C, Heddle ML, Davidson GP. Double-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux. J Pediatr. 2003;143(2):219–23.

    PubMed  Article  CAS  Google Scholar 

  34. 34.

    Orenstein SR, Hassall E. Pantoprazole for symptoms of infant GERD: the emperor has no clothes! J Pediatr Gastroenterol Nutr. 2010;51(4):537.

    PubMed  Article  Google Scholar 

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Susan R. Orenstein declares no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Susan R. Orenstein.

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Orenstein, S.R. Infant GERD: Symptoms, Reflux Episodes & Reflux Disease, Acid & Non-acid Refllux—Implications for Treatment with PPIs. Curr Gastroenterol Rep 15, 353 (2013). https://doi.org/10.1007/s11894-013-0353-1

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Keywords

  • Gastroesophageal reflux (GER)
  • Gastroesophageal reflux disease (GERD)
  • Infant
  • Symptoms
  • Acid reflux
  • Non-acid reflux
  • Proton pump inhibitor (PPI)