Skip to main content

Advertisement

Log in

Exploring the Differential Diagnosis of Joint Complaints in Pediatric Patients with Inflammatory Bowel Disease

  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

Abstract

About one quarter of children with inflammatory bowel disease (IBD) experience an extraintestinal manifestation, with the most common being arthritis or arthralgia. Because of the frequency of these joint complaints and their effect on quality of life, it is important to consider all possible etiologies in order to promptly evaluate, diagnose, and possibly refer to other specialists. Pediatric gastroenterologist and IBD specialists are cognizant of the extraintestinal joint manifestations, but may be less familiar with rheumatic disease and the musculoskeletal examination. We explore the differential diagnosis of joint complaints in children, with a focus on IBD-related disease and rheumatic disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

  1. Dotson JL, Hyams JS, Markowitz J, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. J Pediatr Gastroenterol Nutr. 2010;17(1):56–61.

    Google Scholar 

  2. Jose FA, Garnett EA, Vittinghoff E, et al. Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009;15(1):63–8.

    Article  PubMed  Google Scholar 

  3. Hyams JS. Extraintestinal manifestations of inflammatory bowel disease in children. J Pediatr Gastroenterol Nutr. 1994;19(1):7–21.

    Article  PubMed  CAS  Google Scholar 

  4. Oliva-Hemker M. More than a gut reaction: extraintestinal complications of IBD. Contemp Pediatr. 1999;16:45–64.

    Google Scholar 

  5. Passo MH, Fitzgerald JF, Brandt KD. Arthritis associated with inflammatory bowel disease in children. Relationship of joint disease to activity and severity of bowel lesion. Dig Dis Sci. 1986;31(5):492–7.

    Article  PubMed  CAS  Google Scholar 

  6. Palm O, Moum B, Jahnsen J, Gran JT. The prevalence and incidence of peripheral arthritis in patients with inflammatory bowel disease, a prospective population-based study (the IBSEN study). Rheumatol Oxf. 2001;40(11):1256–61.

    Article  CAS  Google Scholar 

  7. Grossman BJ, DeBenedetti CD. Extraintestinal manifestations of chronic inflammatory bowel disease in children. Proc Inst Med Chic. 1970;28(3):119.

    PubMed  CAS  Google Scholar 

  8. Israel DM, Olson AD, Ilowite NT, Davidson M. Arthritis as the initial manifestation of inflammatory bowel disease in early infancy. J Pediatr Gastroenterol Nutr. 1989;9(1):123–5.

    Article  PubMed  CAS  Google Scholar 

  9. Lindsley CB, Schaller JG. Arthritis associated with inflammatory bowel disease in children. J Pediatr. 1974;84(1):16–20.

    Article  PubMed  CAS  Google Scholar 

  10. Al-Shamali MA, Kalaoui M, Patty I, et al. Ulcerative colitis in Kuwait: a review of 90 cases. Digestion. 2003;67(4):218–24.

    Article  PubMed  Google Scholar 

  11. Palm O, Bernklev T, Moum B, Gran JT. Non-inflammatory joint pain in patients with inflammatory bowel disease is prevalent and has a significant impact on health related quality of life. J Rheumatol. 2005;32(9):1755–9.

    PubMed  Google Scholar 

  12. •• Brakenhoff LK, van der Heijde DM, Hommes DW, et al. The joint-gut axis in inflammatory bowel diseases. J Crohns Colitis. 2010;4(3):257–68. This article serves as a review of various arthropathies associated with inflammatory bowel disease, including axial and peripheral arthropathies, evaluation techniques, pathophysiology, and treatment modalities.

    Article  PubMed  Google Scholar 

  13. Lehman TJA. A clinician’s guide to rheumatic disease in children. New York: Oxford University Press, Inc; 2009. p. 417.

    Google Scholar 

  14. McInerny TK AH, Campbell DE, et al. American academy of pediatrics textbook of primary care. Elk Grove Village: American Academy of Pediatrics; 2009. p. 1625–36.

    Google Scholar 

  15. Perlman MH, Patzakis MJ, Kumar PJ, Holtom P. The incidence of joint involvement with adjacent osteomyelitis in pediatric patients. J Pediatr Orthop. 2000;20(1):40–3.

    Article  PubMed  CAS  Google Scholar 

  16. Taccetti G, Trapani S, Ermini M, Falcini F. Reactive arthritis triggered by Yersinia enterocolitica: a review of 18 pediatric cases. Clin Exp Rheumatol. 1994;12(6):681–4.

    PubMed  CAS  Google Scholar 

  17. Krumrey-Langkammerer M, Hafner R. Evaluation of the ILAR criteria for juvenile idiopathic arthritis. J Rheumatol. 2001;28(11):2544–7.

    PubMed  CAS  Google Scholar 

  18. Jaakkola E, Herzberg I, Laiho K, et al. Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis. Ann Rheum Dis. 2006;65(6):775–80.

    Article  PubMed  CAS  Google Scholar 

  19. Salvarani C, Fries W. Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease. World J Gastroenterol. 2009;15(20):2449–55.

    Article  PubMed  Google Scholar 

  20. De Vos M. Joint involvement associated with inflammatory bowel disease. Dig Dis. 2009;27(4):511–5.

    Article  PubMed  Google Scholar 

  21. Beigel F, Schnitzler F, Paul Laubender R, et al. Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-alpha antibody-treated patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011;17(1):91–8.

    Article  PubMed  Google Scholar 

  22. Colombel JF, Loftus Jr EV, Tremaine WJ, et al. The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic experience in 500 patients. Gastroenterology. 2004;126(1):19–31.

    Article  PubMed  CAS  Google Scholar 

  23. Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002;359(9317):1541–9.

    Article  PubMed  CAS  Google Scholar 

  24. Han PD, Cohen RD. Managing immunogenic responses to infliximab: treatment implications for patients with Crohn’s disease. Drugs. 2004;64(16):1767–77.

    Article  PubMed  CAS  Google Scholar 

  25. Kugathasan S, Levy MB, Saeian K, et al. Infliximab retreatment in adults and children with Crohn’s disease: risk factors for the development of delayed severe systemic reaction. Am J Gastroenterol. 2002;97(6):1408–14.

    Article  PubMed  CAS  Google Scholar 

  26. •• Goff I, Bateman B, Myers A, Foster H. Acceptability and practicality of musculoskeletal examination in acute general pediatric assessment. J Pediatr. 2010;156(4):657–62. This article is of particular importance because it discusses the use of pGALs in a clinical setting and highlights portions of the pGALS screening.

    Article  PubMed  Google Scholar 

  27. Foster HE, Kay LJ, Friswell M, et al. Musculoskeletal screening examination (pGALS) for school-age children based on the adult GALS screen. Arthritis Rheum. 2006;55(5):709–16.

    Article  PubMed  CAS  Google Scholar 

  28. Gniewek RA, Sandbulte C, Fox PC. Comparison of antinuclear antibody testing methods by ROC analysis with reference to disease diagnosis. Clin Chem. 1997;43(10):1987–9.

    PubMed  CAS  Google Scholar 

  29. Gotthardt M, Bleeker-Rovers CP, Boerman OC, Oyen WJ. Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques. J Nucl Med. 2010;51(12):1937–49.

    Article  PubMed  Google Scholar 

Download references

Disclosure

Conflicts of interest: J. Dotson—none; W. Crandall—none; and S. Bout-Tabaku—none.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jennifer Dotson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dotson, J., Crandall, W. & Bout-Tabaku, S. Exploring the Differential Diagnosis of Joint Complaints in Pediatric Patients with Inflammatory Bowel Disease. Curr Gastroenterol Rep 13, 271–278 (2011). https://doi.org/10.1007/s11894-011-0181-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11894-011-0181-0

Keywords

Navigation