Skip to main content

Advertisement

SpringerLink
Log in

Intestinal dysmotility and its relationship to sphincter of Oddi dysfunction

  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

Abstract

Sphincter of Oddi dysfunction (SOD) is a clinical entity that presents with pain as the predominant symptom, and patients may require invasive procedures for its proper diagnosis. Those with abnormal sphincter of Oddi manometry (SOM) are commonly treated with endoscopic ablation of the sphincter. The results of such therapy vary and depend on the type of SOD. In the past several years, evidence has emerged of an association between SOD, intestinal dysmotility, and visceral hyperalgesia. This article reviews the evidence supporting such an association.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Geenen JE, Hogan WJ, Doods WJ, et al.: The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with suspected sphincter of Oddi dysfunction. N Engl J Med 1989, 320:82–87.

    Article  PubMed  CAS  Google Scholar 

  2. Hogan WJ, Geenen JE: Biliary dyskinesia. Endoscopy 1998, 20:179–183. An up to date review of classification and treatment of SOD.

    Google Scholar 

  3. Rolny P, Geenen JE, Hogan WJ, et al.: Clinical features, manometric findings and endoscopic therapy results in group I patients with sphincter of Oddi dysfunction. Gastrointest Endosc 1991, 37:84–85.

    Article  Google Scholar 

  4. Lehman GA, Sherman S: Sphincter of Oddi dysfunction. Int J Pancreatol 1996, 20:11–25.

    PubMed  CAS  Google Scholar 

  5. Kumar S, Rathgaber S, Atherly N, et al.: Endoscopic sphincterotomy in postcholecystectomy patients with type III sphincter of Oddi dysfunction [abstract]. Gastrointest Endosc 1992, 38:255.

    Google Scholar 

  6. Botoman VA, Kozareck RA, Novel LA, et al.: Long-term outcome after endoscopic sphincterotomy in patients with biliary colic and suspected sphincter of Oddi dysfunction. Gastrointest Endosc 1994, 40:165–170.

    Article  PubMed  CAS  Google Scholar 

  7. Yokohata K, Tanaka M: Cyclic motility of the sphincter of Oddi. J Hepatobiliary Pancreat Surg 2000, 7:178–182.

    Article  PubMed  CAS  Google Scholar 

  8. Allescher HD, Safrany L, Heuhaus H, et al.: Aerobilia and hypomotility of the sphincter of Oddi in a patient with chronic intestinal pseudo-obstruction. Gastroenterology 1992, 102:1782–1787.

    PubMed  CAS  Google Scholar 

  9. Soffer EE, Johlin FC: Intestinal dysmotility in patients with sphincter of Oddi dysfunction: a reason for failed response to sphincterotomy. Dig Dis Sci 1994, 39:1942–1946. This article addresses the link between abnormal intestinal motility and SOD, and the failure to respond to ES in patients with abnormal intestinal motility.

    Article  PubMed  CAS  Google Scholar 

  10. Evans PR, Bak YT, Dowsett JF, et al.: Small bowel dysmotility in patients with postcholecystectomy sphincter of Oddi dysfunction. Dig Dis Sci 1997, 42:1507–1512. Another article addressing the link between abnormal intestinal motility and SOD.

    Article  PubMed  CAS  Google Scholar 

  11. Utsonomiya N, Tanaka M, Ogawa Y, et al.: Pain associated with phase III of the duodenal migrating motor complex in patients with postcholecystectomy biliary dyskinesia. Gastrointest Endosc 2000, 51:528–534.

    Article  Google Scholar 

  12. Wood DJ: Physiology of the enteric nervous system. In Physiology of the Gastrointestinal Tract. Edited by Johnson LR. New York: Raven Press; 1987:67–109.

    Google Scholar 

  13. Mawe GM, Kennedy AL: Duodenal neurons provide nicotinic fast synaptic input to sphincter of Oddi neurons in guinea pig. Am J Physiol 1999, 277:G226-G234.

    PubMed  CAS  Google Scholar 

  14. Kennedy AL, Saccone GTP, Mawe GM: Direct neuronal interactions between the duodenum and the sphincter of Oddi. Curr Gastroenterol Rep 2000, 2:104–111. A comprehensive review of intestinal-SO neural connections.

    PubMed  CAS  Google Scholar 

  15. Konomi H, Simula ME, Meedeniya CB, et al.: Induction of duodenal motility activates the sphincter of Oddi (SO)-duodenal reflex in the Australian possum in vitro. Auton Autacoid Pharmacol 2002, 22:109–117.

    Article  PubMed  CAS  Google Scholar 

  16. Deng ZL, Nabae T, Konomi H, et al.: Effects of proximal duodenal transection and anastomosis on interdigestive sphincter of Oddi cyclic motility in conscious dogs. World J Surg 2000, 24:863–869.

    Article  PubMed  CAS  Google Scholar 

  17. Desautels GS, Slivka A, Hutson WR, et al.: Postcholecystectomy pain syndrome: pathophysiology of abdominal pain in sphincter of Oddi type III. Gastroenterology 1999, 116:900–905.

    Article  PubMed  CAS  Google Scholar 

  18. Linder JD, Klapow JC, Linder SD, et al.: Incomplete response to endoscopic sphincterotomy in patients with sphincter of Oddi dysfunction: evidence for a chronic pain disorder. Am J Gastroenterol 2003, 98:1738–1743.

    Article  PubMed  Google Scholar 

  19. Kellow JE: Sphincter of Oddi dysfunction type III: another manifestation of visceral hyperalgesia? Gastroenterology 1999, 116:996–1000. A thorough review of the link between SOD and functional gut disorders.

    Article  PubMed  CAS  Google Scholar 

  20. Whyatt AP: The relationship of the sphincter of Oddi to the stomach, duodenum, and gallbladder. J Physiol 1967, 193:225–243.

    Google Scholar 

  21. Nakayama S, Mori T: Effects of distension of the gall bladder and bile ducts on the movement of the stomach and intestine in the dog. J Appl Physiol 1967, 17:458–465.

    CAS  Google Scholar 

  22. Mertz H, Naliboff B, Munakata J, et al.: Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995, 109:40–52.

    Article  PubMed  CAS  Google Scholar 

  23. Evans PR, Sowsett JF, Bak Y-T, et al.: Abnormal sphincter of Oddi response to cholecystokinin in post-cholecystectomy syndrome patients with irritable bowel syndrome: the ‘irritable sphincter.’ Dig Dis Sci 1995, 40:1149–1156.

    Article  PubMed  CAS  Google Scholar 

  24. Kozarek RA: Biliary dyskinesia: Are we any closer to defining the entity? Gastrointest Endosc Clin North Am 1993, 3:167–178.

    Google Scholar 

  25. Fisher S, Breckan K, Andrews H, et al.: Psychiatric screening for patients with fecal incontinence on chronic constipation referred for surgical treatment. Br J Surg 1998, 76:352–355.

    Article  Google Scholar 

  26. Redmind J, Smith G, Barosfky I, et al.: Physiological test to predict long-term outcome of total abdominal colectomy for intractable constipation. Am J Gastroenterol 1995, 90:748–753.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA

    Claudia Sanmiguel MD & Edy E. Soffer MD

Authors
  1. Claudia Sanmiguel MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edy E. Soffer MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sanmiguel, C., Soffer, E.E. Intestinal dysmotility and its relationship to sphincter of Oddi dysfunction. Curr Gastroenterol Rep 6, 137–139 (2004). https://doi.org/10.1007/s11894-004-0041-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11894-004-0041-2

Keywords

Search

Navigation