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New developments in childhood Celiac Disease

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Abstract

Celiac disease (CD) is one of the most common lifelong disorders in Europe and the United States, in both children and adults. It is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. This review addresses new developments in CD with respect to pediatric patients and emphasizes the need for awareness among health-care professionals. The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted.

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References and Recommended Reading

  1. Fasano A, Catassi C: Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001, 120:636–651.

    Article  PubMed  CAS  Google Scholar 

  2. American Gastroenterological Association medical position statement: celiac sprue. Gastroenterology 2001, 120:1522–1525.

    Article  Google Scholar 

  3. Kolho KL, Farkkila MA, Savilahti E: Undiagnosed coeliac disease is common in Finish adults. Scand J Gastroenterol 1998, 33:1280–1283.

    Article  PubMed  CAS  Google Scholar 

  4. Catassi C, Fabiani E, Ratsch IM, et al.: The coeliac iceberg in Italy: a multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 1996, 412:29–35.

    PubMed  CAS  Google Scholar 

  5. Not T, Horvath K, Hill ID, et al.: Celiac disease in the USA: high prevalence of antiendomysium antibodies in healthy blood donors. Scand J Gastroenterol 1998, 33:494–498.

    Article  PubMed  CAS  Google Scholar 

  6. Gandolfi L, Pratesi R, Cordoba JC, et al.: Prevalence of celiac disease among blood donors in Brazil. Am J Gastroenterol 2000, 95:689–692.

    Article  PubMed  CAS  Google Scholar 

  7. Gomez JC, Selvaggio GS, Viola M, et al.: Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area. Am J Gastroenterol 2001, 96:2700–2704.

    Article  PubMed  CAS  Google Scholar 

  8. Hovell CJ, Collett JA, Vautier G, et al.: High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening? Med J Aust 2001, 175:247–250.

    PubMed  CAS  Google Scholar 

  9. Sood A, Midha V, Sood N, et al.: Increasing incidence of celiac disease in India. Am J Gastroenterol 2001, 96:2804–2805.

    Article  PubMed  CAS  Google Scholar 

  10. Catassi C, Rätsch IM, Gandolfi L, et al.: Why is coeliac disease endemic in the people of the Sahara? Lancet 1999, 354:647–648.

    Article  PubMed  CAS  Google Scholar 

  11. Rätsch IM, Catassi C: Coeliac disease: a potentially treatable health problem of Saharawi refugee children. Bull WHO 2001, 79:541–545.

    PubMed  Google Scholar 

  12. Papadopoulos GK, Wijmenga C, Koning F: Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life. J Clin Invest 2001, 108:1261–1266.

    Article  PubMed  CAS  Google Scholar 

  13. Sollid LM: Molecular basis of celiac disease. Annu Rev Immunol 2000, 18:53–81.

    Article  PubMed  CAS  Google Scholar 

  14. Greco L, Babron MC, Corazza GR, et al.: Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease children. Ann Hum Genet 2001, 65:35–41.

    Article  PubMed  CAS  Google Scholar 

  15. King AL, Fraser JS, Moodie SJ, et al.: Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11. Ann Hum Genet 2001, 65:377–386.

    Article  PubMed  CAS  Google Scholar 

  16. Wang W, Uzzau S, Goldblum SE, Fasano A: Human zonulin: a potential modulator of intestinal tight junctions. J Cell Sci 2000, 113:4435–4440.

    PubMed  CAS  Google Scholar 

  17. Fasano A, Not T, Wang W, et al.: Zonulin: a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000, 358:1518–1519. This paper describes the discovery of zonulin, a molecule that modulates intercellular tight junctions, the upregulation of which seems to be involved in CD pathogenesis.

    Article  Google Scholar 

  18. Schuppan D: Current concepts of celiac disease pathogenesis. Gastroenterology 2000, 119:234–242. A comprehensive review on this topic.

    Article  PubMed  CAS  Google Scholar 

  19. Anderson RP, Degano P, Godkin AJ, et al.: In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat Med 2000, 6:337–342.

    Article  PubMed  CAS  Google Scholar 

  20. van de Wal Y, Kooy YM, van Veelen P, et al.: Glutenin is involved in the gluten-driven mucosal T cell response. Eur J Immunol 1999, 29:3133–3139.

    Article  PubMed  Google Scholar 

  21. Dieterich W, Ehris T, Bauer M, et al.: Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997, 3:797–801. This paper reports the identification of tissue transglutaminase as the principle antigen recognized by antiendomysium antibodies.

    Article  PubMed  CAS  Google Scholar 

  22. Dieterich W, Laag E, Schopper H, et al.: Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 1998, 115:1317–1321.

    Article  PubMed  CAS  Google Scholar 

  23. Maki M: Celiac disease. In Gastrointestinal Functions. Edited by Delvin EE, Lentze MJ. Philadelphia: Lippincott, Williams & Wilkins; 2001:257–274.

    Google Scholar 

  24. Leon F, R-Pena R, Camarero C, et al.: Limitations of anti-guinea pig liver transglutaminase IgA screening of celiac disease. Gastroenterology 2001, 120:586–587.

    Article  PubMed  CAS  Google Scholar 

  25. Baldas V, Tommasini A, Trevisiol C, et al.: Development of a novel rapid non-invasive screening test for coeliac disease. Gut 2000, 47:628–631.

    Article  PubMed  CAS  Google Scholar 

  26. Lagerqvist C, Ivarsson A, Juto P, et al.: Screening for adult coeliac disease: which serological marker(s) to use? J Intern Med 2001, 250:241–248.

    Article  PubMed  CAS  Google Scholar 

  27. Schuppan D, Hahn EG: IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening. Eur J Gastroenterol Hepatol 2001, 13:635–637.

    Article  PubMed  CAS  Google Scholar 

  28. Fabiani E, Catassi C: The serum IgA class anti-tissue transglutaminase antibodies in the diagnosis and follow up of coeliac disease: results of an international multi-centre study. International Working Group on Eu-tTG. Eur J Gastroenterol Hepatol 2001, 13:659–665.

    Article  PubMed  CAS  Google Scholar 

  29. Carroccio A, Fabiani E, Iannitto E, et al.: Tissue transglutaminase autoantibodies in patients with non-Hodgkin’s lymphoma: case reports. Digestion 2000, 62:271–275.

    Article  PubMed  CAS  Google Scholar 

  30. Koop I, Ilchmann R, Izzi L, et al.: Detection of autoantibodies against tissue transglutaminase in patients with celiac disease and dermatitis herpetiformis. Am J Gastroenterol 2000, 95:2009–2014.

    Article  PubMed  CAS  Google Scholar 

  31. Bao F, Yu L, Babu S, et al.: One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase antibodies. J Autoimmun 1999, 13:143–148.

    Article  PubMed  CAS  Google Scholar 

  32. Cataldo F, Marino V, Ventura A, et al.: Prevalence and clinical features of immunoglobulin A deficiency in coeliac disease: an Italian multicentre study. Gut 1998, 42:362–365.

    Article  PubMed  CAS  Google Scholar 

  33. Guandalini S, Gupta P: Do you still need a biopsy to diagnosis celiac disease? Curr Gastroenterol Rep 2001, 3:385–391.

    PubMed  CAS  Google Scholar 

  34. Farrell RJ, Kelly CP: Diagnosis of celiac sprue. Am J Gastroenterol 2001, 96:3237–3246.

    Article  PubMed  CAS  Google Scholar 

  35. Rostami K, Kerckhaert J, Tiemessen R, et al.: Sensitivity of antiendomysium and antigliadin antibodies in untreated coeliac disease: disappointing in clinical practice. Am J Gastroenterol 1999, 94:88–894.

    Article  Google Scholar 

  36. Ravelli AM, Tobanelli P, Minelli L, et al.: Endoscopic features of celiac disease in children. Gastrointest Endosc 2001, 54:736–742.

    Article  PubMed  CAS  Google Scholar 

  37. Mackey J, Treem WR, Worley G, et al.: Frequency of celiac disease in individuals with Down syndrome in the United States. Clin Pediatr 2001, 40:249–252.

    CAS  Google Scholar 

  38. Book L, Hart A, Black J, et al.: Prevalence and clinical characteristics of celiac disease in Downs syndrome in a U.S. study. Am J Med Genet 2001, 98:70–74.

    Article  PubMed  CAS  Google Scholar 

  39. Mora S, Barera G, Beccio S, et al.: A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease. J Pediatr 2001, 139:516–521.

    Article  PubMed  CAS  Google Scholar 

  40. Gobbi G, Bouquet F, Greco L, et al.: Coeliac disease, epilepsy, and cerebral calcifications. Lancet 1992, 340:439–443.

    Article  PubMed  CAS  Google Scholar 

  41. Labate A, Gambardella A, Messina D, et al.: Silent celiac disease in patients with childhood localization-related epilepsies. Epilepsia 2001, 42:1153–1155.

    Article  PubMed  CAS  Google Scholar 

  42. Larizza D, Calcaterra V, De Giacomo C, et al.: Celiac disease in children with autoimmune thyroid disease. J Pediatr 2001, 139:738–740.

    Article  PubMed  CAS  Google Scholar 

  43. Ventura A, Neri E, Ughi C, et al.: Gluten-dependent diabetesrelated and thyroid-related autoantibodies in patients with celiac disease. J Pediatr 2000, 137:263–265.

    Article  PubMed  CAS  Google Scholar 

  44. Sategna Guidetti C, Solerio E, Scaglione N, et al.: Duration of gluten exposure in adult coeliac disease does nor correlate with the risk for autoimmune disorders. Gut 2001, 49:502–505.

    Article  PubMed  CAS  Google Scholar 

  45. Ventura A, Magazzù G, Greco L, et al.: Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. Gastroenterology 1999, 117:297–303. This paper provides indirect evidence of the relationship between the length of gluten exposure and the risk of autoimmune diseases in CD patients.

    Article  PubMed  CAS  Google Scholar 

  46. Hin H, Bird G, Fisher P, Mahy N, Jewell D: Coeliac disease in primary care: case finding study. BMJ 1999, 318:164–167.

    PubMed  CAS  Google Scholar 

  47. Ventura A, Facchini S, Amantidu C, et al.: Searching for celiac disease in pediatric general practice. Clin Pediatr 2001, 40:575–577.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Celiac Research, Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, 685 West Baltimore Street, HSF Building, Room 465, 21201, Baltimore, MD, USA

    Carlo Catassi MD & Alessio Fasano MD

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  1. Carlo Catassi MD
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  2. Alessio Fasano MD
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Catassi, C., Fasano, A. New developments in childhood Celiac Disease. Curr Gastroenterol Rep 4, 238–243 (2002). https://doi.org/10.1007/s11894-002-0069-0

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  • DOI: https://doi.org/10.1007/s11894-002-0069-0

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