Esophageal manifestations of dermatologic disease


This review describes those skin conditions, or conditions where skin involvement is a prominent feature, that may present with esophageal manifestations. These conditions have been categorized in many different ways. For the purposes of this review, esophageal manifestations of skin conditions are classified as bullous diseases, hyperkeratotic diseases, collagen vascular diseases, syndromes associated with cancer, and miscellaneous diseases.

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References and Recommended Reading

  1. 1.

    Marinkovich MP: Update on inherited bullous dermatoses. Dermatol Clin 1999, 17:473–485. This recent review on the inherited bullous skin diseases is highly recommended. The author reviews recent advances in the understanding of the genetic alterations and their expression in these devastating diseases. The article includes an excellent discussion of epidermolysis bullosa.

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Kern IB, Eisenberg M, Willis S: Management of oesophageal stenosis in epidermolysis bullosa dystrophica. Arch Dis Child 1989, 64:551–556.

    PubMed  CAS  Google Scholar 

  3. 3.

    Travis SP, McGrath JA, Turnbull AJ, et al.: Oral and gastrointestinal manifestations of epidermolysis bullosa. Lancet 1992, 340:1505–1506.

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Stewart MI, Woodley DT, Briggaman RA: Epidermolysis bullosa acquisita and associated symptomatic esophageal webs. Arch Dermatol 1991, 127:373–377.

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Nousari HC, Anhalt GJ: Pemphigus and bullous pemphigoid. Lancet 1999, 354:667–672.

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Mignogna MD, Lo Muzio L, Galloro G, et al.: Oral pemphigus: clinical significance of esophageal involvement: report of eight cases. Oral Surg Oral Med Oral Pathol Oral Radiol 1997, 84:179–184.

    Article  CAS  Google Scholar 

  7. 7.

    Trattner A, Lurie R, Leiser A, et al.: Esophageal involvement in pemphigus vulgaris: a clinical, histologic, and immunopathologic study. J Amer Acad Dermatol 1991, 24:223–226.

    CAS  Google Scholar 

  8. 8.

    Gomi H, Akiyama M, Yakabi K, et al.: Oesophageal involvement in pemphigus vulgaris. Lancet 1999, 354:1794.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Venkataram M, Ramakrishna BS, Al-Hilli F: Relapse of pemphigus vulgaris presenting with haematemesis. Dermatology 2001, 203:85–86.

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Stanley JR: Therapy of pemphigus vulgaris. Arch Dermatol 1999, 135:76–78.

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Ahmed AR, Hombal SM: Cicatricial pemphigoid. Int J Dermatol 1986, 25:90–96.

    PubMed  CAS  Google Scholar 

  12. 12.

    Soong C, Bynum TE: The endoscopic appearance of pemphigoid esophagitis. Gastrointest Endosc 1972, 19:17–18.

    PubMed  CAS  Google Scholar 

  13. 13.

    Mahe A, Keita S, Blanc L, Bobin P: Esophageal necrosis in the Stevens-Johnson syndrome. J Am Acad Dermatol 1993, 29:103–104.

    PubMed  CAS  Google Scholar 

  14. 14.

    Sasadeusz JJ, Sacks SL: Herpes latency, meningitis, radiculomyelopathy and disseminated infection. Genitourin Med 1994, 70:369–377.

    PubMed  CAS  Google Scholar 

  15. 15.

    Burge SM: Hailey-Hailey disease: the clinical features, response to treatment and prognosis. Br J Dermatol 1992, 126:275–282.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Porter SR, Kirby A, Olsen I, Barrett W: Immunologic aspects of dermal and oral lichen planus: a review. Oral Surg Oral Med Oral Pathol Oral Radiol 1997, 83:358–366.

    Article  CAS  Google Scholar 

  17. 17.

    Harewood GC, Murray JA, Cameron AJ: Esophageal lichen planus: the Mayo Clinic experience. Dis Esophagus 1999, 12:309–311. In this review of the Mayo Clinic experience over the previous 15 years, the authors render an expert opinion concerning diagnosis and management.

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Ukleja A, DeVault KR, Stark ME, Achem SR: Lichen planus involving the esophagus. Dig Dis Sci 2001, 46:2292–2297. This is the largest and most up-to-date review of reported cases of lichen planus.

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Eisen D: The evaluation of cutaneous, genital, scalp, nail, esophageal, and ocular involvement in patients with oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol 1999, 88:431–436.

    Article  CAS  Google Scholar 

  20. 20.

    Maillefer RH, Greydanus MP: To B or not to B: is tylosis B truly benign? Two North American genealogies. Am J Gastroenterol 1999, 94:829–834. A concise review of tylosis and esophageal cancer. The genetic and clinical distinctions between the two types are documented and well cited.

    PubMed  CAS  Google Scholar 

  21. 21.

    Lucker GP, Van de Kerkhof PC, Steijlen PM: The hereditary palmoplantar keratoses: an updated review and classification. Br J Dermatol 1994, 131:1–14.

    PubMed  Article  CAS  Google Scholar 

  22. 22.

    Hsu YS, Lien GS, Lai HH, et al.: Acrokeratosis paraneoplastica (Bazex syndrome) with adenocarcinoma of the colon: report of a case and review of the literature. J Gastroenterol 2000, 35:460–464. This is a case report and review of a relatively new syndrome that is not well recognized in the medical community. The bibliography includes recent reviews on the subject; however, the article is itself an accurate and concise review.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Kozlowski LM, Nigra TP: Esophageal acanthosis nigricans in association with adenocarcinoma from an unknown primary site. J Am Acad Dermatol 1992, 26:348–351.

    PubMed  CAS  Article  Google Scholar 

  24. 24.

    Sjögren RW: Gastrointestinal features of scleroderma. Curr Opin Rheumatol 1996, 8:569–575.

    PubMed  Article  Google Scholar 

  25. 25.

    Katzka DA, Reynolds JC, Saul SH, et al.: Barrett’s metaplasia and adenocarcinoma of the esophagus in scleroderma. Am J Med 1987, 82:46–52.

    PubMed  Article  CAS  Google Scholar 

  26. 26.

    Mansour KA. 1988: Surgery for scleroderma of the esophagus: a 12-year experience: updated in 1995. Ann Thorac Surg 1995, 60:227.

    PubMed  CAS  Google Scholar 

  27. 27.

    Hostein J, Fournet J: Gastrointestinal manifestations of collagen diseases. Dig Dis 1986, 4:240–252.

    PubMed  CAS  Google Scholar 

  28. 28.

    Redleaf MI, Moran WJ, Gruber B: Mycosis fungoides involving the cervical esophagus. Arch Otolaryngol Head Neck Surg 1993, 119:690–693.

    PubMed  CAS  Google Scholar 

  29. 29.

    Schneider A, Martini N, Burt ME: Malignant melanoma metastatic to the esophagus. Ann Thorac Surg 1993, 55:516–517.

    PubMed  CAS  Article  Google Scholar 

  30. 30.

    Hoffman RM, Jaffe PE: Plummer-Vinson syndrome: a case report and literature review. Arch Intern Med 1995, 155:2008–2011.

    PubMed  Article  CAS  Google Scholar 

  31. 31.

    Kay PS, Soetikno RM, Mindelzun R, Young HS: Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden’s disease. Am J Gastroenterol 1997, 92:1038–1040.

    PubMed  CAS  Google Scholar 

  32. 32.

    Brown KE, Kelly TE, Myers BM: Gastrointestinal involvement in a woman with dyskeratosis congenita. Dig Dis Sci 1993, 38:181–184.

    PubMed  Article  CAS  Google Scholar 

  33. 33.

    Rogers RS III: Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders. Semin Cutan Med Surg 1997, 16:278–283.

    PubMed  Article  Google Scholar 

  34. 34.

    Kasahara Y, Tanaka S, Nishino M, et al.: Intestinal involvement in Behcet’s disease: review of 136 surgical cases in the Japanese literature. Dis Colon Rectum 1981, 24:103–106.

    PubMed  Article  CAS  Google Scholar 

  35. 35.

    Brinson RR, Schuman BM, Mills LR, et al.: Multiple squamous papillomas of the esophagus associated with Goltz syndrome. Am J Gastroenterol 1987, 82:1177–1179.

    PubMed  CAS  Google Scholar 

  36. 36.

    Vase P, Grove O: Gastrointestinal lesions in hereditary hemorrhagic telangiectasia. Gastroenterology 1986, 91:1079–1083.

    PubMed  CAS  Google Scholar 

  37. 37.

    Spencer GD, Shulman HM, Myerson D, et al.: Diffuse intestinal ulceration after marrow transplantation: a clinicopathologic study of 13 patients. Hum Pathol 1986, 17:621–633.

    PubMed  Article  CAS  Google Scholar 

  38. 38.

    McDonald GB, Sullivan KM, Schuffler MD, et al.: Esophageal abnormalities in chronic graft-versus-host disease in humans. Gastroenterology 1981, 80:914–921.

    PubMed  CAS  Google Scholar 

  39. 39.

    Kirkpatrick CH: Chronic mucocutaneous candidiasis. J Am Acad Dermatol 1994, 31:S14-S17.

    PubMed  CAS  Article  Google Scholar 

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Wise, J.L., Murray, J.A. Esophageal manifestations of dermatologic disease. Curr Gastroenterol Rep 4, 205–212 (2002).

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  • Pemphigus
  • Lichen Planus
  • Bullous Pemphigoid
  • Hereditary Hemorrhagic Telangiectasia
  • Epidermolysis Bullosa