Although medical and surgical treatments are available for gastroesophageal reflux disease, endoscopic therapies for this condition are relatively new. This review describes the principles behind such treatments as well as the individual procedures themselves, focusing on mechanisms of action, safety and tolerability, and efficacy in animal and human clinical trials. Future trends in endoscopic therapy are discussed.
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References and Recommended Reading
Locke GR, Talley NJ, Fett SL, et al.: Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997, 112:1448–1456.
Lagergren J, Bergstrom R, Lindgren A, Nyren O: Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999, 340:825–831.
Chiba N, DeGara CJ, Wilkinson JM, et al.: Speed of healing and symptom relief in grade II-IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 1997, 112:1798–1810.
Lundell L, Mietinnen P, Myrvold HE, et al.: Continued (5-year) followup of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001, 192:172–179.
Triadafilopoulos G, DiBaise JK, Nostrant TT, et al.: Radiofrequency energy delivery to the gastroesophageal junction for the treatment of GERD. Gastrointest Endosc 2001, 53:407–415.
Utley DS, Kim MS, Vierra MA, Triadafilopoulos G: Augmentation of lower esophageal sphincter pressure and gastric yield pressure after radiofrequency energy delivery to the gastroesophageal junction: a porcine model. Gastrointest Endosc 2000, 52:81–86.
Kim MS, Dent J, Holloway R, Utley DS: Radiofrequency energy delivery to the gastric cardia inhibits triggering of transient lower esophageal sphincter relaxation in a canine model [abstract]. Gastroenterology 2000, 188:A4790.
Chang KJ, Utley DS: Endoscopic ultrasound (EUS) in-vivo assessment of radiofrequency (RF) energy delivery to the gastroesophageal (GE) junction in a porcine model [abstract]. Gastrointest Endosc 2001, 53:A2001.
DiBaise JK, Quigley EM: Efficacy of radiofrequency energy delivery to the lower esophageal sphincter in the treatment of GERD [abstract]. Gastrointest Endosc 2000, 51:A3454.
Tam WCE, Schoeman MN, Zhang Q, et al.: Delivery of radiofrequency energy (RFe) to the lower esophageal sphincter (LES) and gastric cardia inhibits transient LES relaxations and gastroesophageal reflux in patients with reflux disease [abstract]. Gastroenterology 2001, 120:A16.
Triadafilopoulos G, Dibaise JK, Nostrant TT, et al.: The Stretta procedure for the treatment of GERD: 6 and 12 month follow-up of the U.S. open label trial. Gastrointest Endosc 2002, 55:149–156. Report from a large-scale, 12-month, open trial of the Stretta procedure.
Food and Drug Administration: Medical Device Reports. Washington, DC: FDA; 2001. Accessible online at www.fda.gov/cdrh/mdrfile.html
Noar MD, Igari Y, Mulock D, Bidlack D: The large hiatal hernia and failed Nissen fundoplication: initial report of successful treatment using modified radiofrequency ablation (Stretta) technique. Am J Gastroenterol 2001, 96:S27.
Swain P, Park PO, Kjellin T, et al.: Endoscopic gastroplasty for gastroesophageal reflux disease [abstract]. Gastroint Endosc 2000, 51:A144.
Filipi CJ, Lehman GA, Rothstein RI, et al.: Transoral, flexible endoscopic suturing for treatment of GERD: a multicenter trial. Gastrointest Endosc 2001, 53:416–422. Report from a large-scale, 6-month, open trial with Endocinch.
Raijman I, Ben-Menachem T, Reddy G, et al.: Symptomatic response to endoluminal gastroplication (ELGP) in patients with gastroesophageal reflux disease (GERD): a multicenter experience [abstract]. Gastrointest Endosc 2001, 53:A74.
Rothstein RI, Pohl H, Grove M, et al.: Endoscopic gastric plication for the treatment of GERD: two year follow-up results. Am J Gastroenterol 2001, 96:S35.
Maple JT, Alexander JA, Gostout CJ, et al.: Endoscopic gastroplasty for GERD: Not as good as billed? A singlecenter, 6-moth report. Am J Gastroenterol 2001, 96:S22.
Feretis C, Benakis P, Dimopoulos C, et al.: Endoscopic implantation of plexiglass (PMMA) microspheres for the treatment of GERD. Gastrointest Endosc 2001, 53:423–426.
Lehman GA, Deviere J, Haber G, et al.: Lower esophageal sphincter (LES) augmentation therapy for GERD with Enteryx, a biocompatible inert polymer: initial multicenter human trial results [abstract]. Gastrointest Endosc 2001, 53:A123.
O‘Connor KW, Lehman GA: Endoscopic placement of collagen at the lower esophageal sphincter to inhibit gastroesophageal reflux: a pilot study of 10 medically intractable patients. Gastrointest Endosc 1988, 34:106–112.
Johnson DA, Aisenberg J, Cohen L, et al.: Enteryx solution, a minimally invasive injectable treatment for GERD: initial multicenter human trial results. Am J Gastroenterol 2001, 96:S17. Report from a large-scale, open trial of the Enteryx system.
Chuttami R, Kozarek R, Lo S, et al.: A novel endoscopic full thickness plicator for the treatment of GERD: demonstration of safety in pigs [abstract]. Gastrointest Endosc 2001, 53:A132.
Mason RJ, DeMeester TR, Schurr MO, et al.: Peroral endoscopic Nissen fundoplication: the introduction of a new era [abstract]. Gastrointest Endosc 2001, 53:A74.
Fockens P, Bruno MJ, Hirsch DP, et al.: Endoscopic augmentation of the lower esophageal sphincter: pilot study of the Gatekeeper system in patients with gastroesophageal reflux disease. Am J Gastroenterol 2001, 96(suppl):37.
Hogan WJ: Endoscopic treatment modalities for GERD: technologies score or scare? Gastrointest Endosc 2001, 53:541–545.
Lehman G: Endoscopic and endoluminal techniques for control of gastroesophageal reflux: are they ready for widespread clinical application? Gastrointest Endosc 2001, 52:808–811.
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Triadafilopoulos, G. Endoscopic therapies for gastroesophageal reflux disease. Curr Gastroenterol Rep 4, 200–204 (2002). https://doi.org/10.1007/s11894-002-0063-6
- Hiatal Hernia
- Lower Esophageal Sphincter
- Gastroesophageal Reflux Disease
- Endoscopic Therapy