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Nonulcer dyspepsia

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Abstract

Nonulcer dyspepsia is a common condition in clinical practice. It is a heterogeneous disorder, and no single therapeutic agent is effective in all patients. The treatment of nonulcer dyspepsia is still dissatisfactory. Eradication of Helicobacter pylori organisms has a limited role and little effect. Antisecretory therapy has a modest effect in alleviating symptoms. Prokinetic agents may be effective, but selection bias in the trials performed to date may exaggerate their benefit. Partial 5-HT4 agonists stimulate gastric emptying and may also affect gastric accommodation. They are promising but need further study. Data are limited on 5-HT3 antagonists and hypnotherapy. New treatment approaches are necessary for this common and often chronic condition.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, University of Wisconsin Medical School, Aurora Sinai Medical Center, 945 North 12th Street, Room 4040, 53233, Milwaukee, WI, USA

    Nimish Vakil MD

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  1. Nimish Vakil MD
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Vakil, N. Nonulcer dyspepsia. Curr Gastroenterol Rep 4, 455–458 (2002). https://doi.org/10.1007/s11894-002-0020-4

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  • DOI: https://doi.org/10.1007/s11894-002-0020-4

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