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Gut Factors Mediating the Physiological Impact of Bariatric Surgery

  • Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)
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Abstract

Despite decades of obesity research and various public health initiatives, obesity remains a major public health concern. Our most drastic but most effective treatment of obesity is bariatric surgery with weight loss and improvements in co-morbidities, including resolution of type 2 diabetes (T2D). However, the mechanisms by which surgery elicits metabolic benefits are still not well understood. One proposed mechanism is through signals generated by the intestine (nutrients, neuronal, and/or endocrine) that communicate nutrient status to the brain. In this review, we discuss the contributions of gut-brain communication to the physiological regulation of body weight and its impact on the success of bariatric surgery. Advancing our understanding of the mechanisms that drive bariatric surgery-induced metabolic benefits will ultimately lead to the identification of novel, less invasive strategies to treat obesity.

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Funding

This work is supported by NIH R01DK121995, NIH R01DK107282, and by an American Diabetes Association grant (1–19-IBS-252) to DAS and institutional NIH Training grant NIH T32DK120521 to MB.

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  1. Department of Pediatrics, Nutrition Section, University of Colorado Anschutz Medical Campus, 12801 E 17th Ave. Research Complex 1 South 7th Floor, Aurora, CO, 80045, USA

    Maigen Bethea & Darleen A. Sandoval

  2. Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E 17th Ave. Research Complex 1 South 7th Floor, Aurora, CO, 80045, USA

    Maigen Bethea & Darleen A. Sandoval

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Bethea, M., Sandoval, D.A. Gut Factors Mediating the Physiological Impact of Bariatric Surgery. Curr Diab Rep 22, 371–383 (2022). https://doi.org/10.1007/s11892-022-01478-9

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