Abstract
Purpose of Review
The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2.
Recent Findings
Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation.
Summary
Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.
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Change history
22 June 2020
The original version of this review article unfortunately contained a mistake.
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The trial was registered under the number ISRCTN7059583, was performed according to the declaration of Helsinki and all local ethics committees approved the study.
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Jürgen Harreiter, Gernot Desoye, Mireille van Poppel, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy, Roland Devlieger and David Simmons declare that they have no conflict of interest.
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Appendix The DALI core investigators group
Appendix The DALI core investigators group
G. Desoye1, D. Simmons2, R. Corcoy3,4, J.M. Adelantado3, R. Devlieger5, P. Damm6, E.R. Mathiesen6, D.M. Jensen7, L.L. Andersen7, A. Lapolla8, MG. Dalfrà8, A Bertolotto9, E. Wender-Ozegowska10, A. Zawiejska10, D J. Hill11, M.N.M. van Poppel12, F.J. Snoek13, A. Kautzky-Willer14, FP. Dunne15
Gernot Desoye, PhD 1Department of Obstetrics and Gynaecology, Medizinische Universitaet Graz, Graz, Austria. E: gernot.desoye@medunigraz.at
David Simmons, MD (Cantab) 2Institute of Metabolic Science, Addenbrookes Hospital, Cambridge, England and Macarthur Clinical School, Western Sydney University, Sydney, Australia. E: Da.simmons@westernsydney.edu.au
Rosa Corcoy, PhD 3Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
4CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III, Zaragoza, Spain E: RCorcoy@santpau.cat
Juan M Adelantado, PhD 3Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. E: JAdelantado@santpau.cat
Roland Devlieger, PhD 5KU Leuven Department of Development and Regeneration: Pregnancy, Fetus and Neonate. Gynaecology and Obstetrics, University Hospitals Leuven, Belgium. E: roland.devlieger@uzleuven.be
Peter Damm, DMsc. 6Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. E: pdamm@dadlnet.dk
Elizabeth Reinhardt Mathiesen, DMsc. 6Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. E: elisabeth.reinhardt.mathiesen@regionh.dk
Dorte Moeller Jensen, PhD 7Department of Endocrinology and Department of Gynaecology and Obstetrics, Odense University Hospital, Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. E: Dorte.Moeller.Jensen@rsyd.dk
Lise Lotte T. Anderson, MD. 7Department of Endocrinology and Department of Gynaecology and Obstetrics, Odense University Hospital, Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark. E: lise.lotte.andersen@rsyd.dk
Annunziata Lapolla, MD 8Universita Degli Studi di Padova, Padua, Italy. E: annunziata.lapolla@unipd.it
Maria G Dalfrà, MD 8Universita Degli Studi di Padova, Padua, Italy. E: u053734@sanita.padova.it
Alessandra Bertolotto, PhD. 9Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. E: alessandrabertolotto1959@yahoo.it
Ewa Wender-Ozegowska, PhD. 10Division of Reproduction, Poznan University of Medical Sciences, Poznan, Poland. E: ewaoz@post.pl
Agnieszka Zawiejska, PhD 10Division of Reproduction, Poznan University of Medical Sciences, Poznan, Poland E: agazaw@post.home.pl
David J.Hill, DPhil. 11Recherche en Santé Lawson SA, St. Gallen, Switzerland. E: david.hill@lawsonresearch.com
Mireille N.M. van Poppel, PhD. 12Department of Public and Occupational Health, EMGO+-Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands and Institute of Sport Science, University of Graz, Graz, Austria. E: mireille.van-poppel@uni-graz.at
Frank J Snoek, PhD 13Department of Medical Psychology, EMGO+-Institute for Health and Care Research, VU University Medical Centre and Medical Psychology AMC, Amsterdam, the Netherlands. E: fj.snoek@vumc.nl
Alexandra Kautzky-Willer, MD 14Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria. E: alexandra.kautzky-willer@meduniwien.ac.at
Fidelma Dunne, PhD 15National University of Ireland, Galway, Ireland. E: fidelma.dunne@nuigalway.ie
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Harreiter, J., Desoye, G., van Poppel, M.N.M. et al. The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies?. Curr Diab Rep 19, 162 (2019). https://doi.org/10.1007/s11892-019-1282-7
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DOI: https://doi.org/10.1007/s11892-019-1282-7