Purpose of Review
Breastfeeding has short- and long-term benefits for child health. In this systematic review, we updated a review on the association between breastfeeding and type 2 diabetes.
A meta-analysis published in 2015 reported that breastfeeding protects against type 2 diabetes (pooled odds ratio, 0.65 (95% confidence interval, 0.48; 0.86)). In the present update, we identified three recently published studies. An internet-based study reported that at a mean age of 25.6 years, exclusive breastfeeding in the first 6 months protected against type 2 diabetes (odds ratio, 0.63 (95% confidence interval, 0.41; 0.95)). In a retrospective cohort, those subjects who had been breastfed before hospital discharge were less likely of presenting diabetes (odds ratio, 0.83 (95% confidence interval, 0.69; 0.99)). In a case-control study, the odds of type 2 diabetes in adolescents was lower for those exclusively breastfed at hospital discharge (odds ratio, 0.52 (95% confidence interval, 0.36; 0.74)). In the meta-analysis, the pooled odds ratio was 0.67 (95% confidence interval, 0.56; 0.80).
The updated systematic review and meta-analysis suggests that breastfeeding protects from type 2 diabetes.
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Sankar MJ, Sinha B, Chowdhury R, Bhandari N, Taneja S, Martines J, et al. Optimal breastfeeding practices and infant and child mortality: a systematic review and meta-analysis. Acta Paediatr. 2015;104:3–13.
Horta BL, Loret De Mola C, Victora CG. Breastfeeding and intelligence: a systematic review and meta-analysis. Acta Paediatr. 2015;104:14–9.
Victora CG, Horta BL, de Mola CL, Quevedo L, Pinheiro RT, Gigante DP, et al. Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Heal. 2015;3:199–205.
Straub N, Grunert P, Northstone K, Emmett P. Economic impact of breast-feeding-associated improvements of childhood cognitive development, based on data from the ALSPAC. Br J Nutr. 2016:1–6.
Horta BL, Loret De Mola C, Victora CG. Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 2015;104:30–7.
• Horta BL, Victora CG, França GVA, Hartwig FP, Ong KK, Rolfe EDL, et al. Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up. Sci Rep. 2018;8:2530 This study reported that even among adults, breastfeeding moderated the association between the FTO variant rs9939609 and adiposity.
Abarin T, Wu YY, Warrington N, Lye S, Pennell C, Briollais L. The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study. Int J Epidemiol. 2012;41:1650–60.
Dedoussis GVZ, Ynnakoulia M, Timpson NJ, Manios Y, Kanoni S, Scott RA, et al. Does a short breastfeeding period protect from FTO-induced adiposity in children? Int J Pediatr Obes. 2011;6:e326–35.
Baur LA, O’Connor J, Pan DA, Kriketos AD, Storlien LH. The fatty acid composition of skeletal muscle membrane phospholipid: its relationship with the type of feeding and plasma glucose levels in young children. Metabolism. 1998;47:106–12.
Singhal A. The role of infant nutrition in the global epidemic of non-communicable disease. Proc Nutr Soc. 2016;75:162–8.
Lucas A, Blackburn AM, Aynsley-Green A, Sarson DL, Adrian TE, Bloom SR. Breast vs bottle: endocrine responses are different with formula feeding. Lancet. 1980;8181:1267–9.
Ladomenou F, Kafatos A, Galanakis E. Risk factors related to intention to breastfeed, early weaning and suboptimal duration of breastfeeding. Acta Paediatr. 2007;96:1441–4.
Richiardi L, Bellocco R, Zugna D. Mediation analysis in epidemiology: methods, interpretation and bias. Int J Epidemiol. 2013;42:1511–9.
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.
Egger M, Davey Smith G, Schneider M, Minder C, Mulrow C, Egger M, et al. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315:629–34.
Berkey CS, Hoaglin DC, Mosteller F, Colditz GA. A random-effects regression model for meta-analysis. Stat Med. 1995;14:395–411.
•• Martens PJ, Shafer LA, Dean HJ, Sellers EAC, Yamamoto J, Ludwig S, et al. Breastfeeding initiation associated with reduced incidence of diabetes in mothers and offspring. Obstet Gynecol. 2016;128:1095–104 This study reported that incidence of breastfeeding reduces the risk of type-2 diabetes among the mothers and their offsprings.
Halipchuk J, Temple B, Dart A, Martin D, Sellers EAC. Prenatal, obstetric and perinatal factors associated with the development of childhood-onset type 2 diabetes. Can J Diabetes. 2018;42:71–7.
Elisabetta Baldassarre M, Di Mauro A, Cintoli A, Mincarone G, Tafuri S, Laforgia N. Non-communicable chronic diseases: the role of neonatal characteristics. Iran J Pediatr. 2017;27:e9322.
Young TK, Martens PJ, Taback SP, Sellers EAC, Dean HJ, Cheang M, et al. Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch Pediatr Adolesc Med. 2002;156:651–5.
Izadi V, Kelishadi R, Qorbani M, EsmaeilMotlagh M, Taslimi M, Heshmat R, et al. Duration of breast-feeding and cardiovascular risk factors among Iranian children and adolescents: the CASPIAN III study. Nutrition. 2013;29:744–51.
Mayer-Davis EJ, Dabelea D, Lamichhane AP, D’Agostino RB Jr, Liese AD, Thomas J, et al. Breast-feeding and type 2 diabetes in the youth of three ethnic groups: the SEARCh for diabetes in youth case-control study. Diabetes Care. 2008;31:470–5.
Evenhouse E, Reilly S. Improved estimates of the benefits of breastfeeding using sibling comparisons to reduce selection bias. Health Serv Res. 2005;40:1781–802.
Fall CHD, Borja JB, Osmond C, Richter L, Bhargava SK, Martorell R, et al. Infant-feeding patterns and cardiovascular risk factors in young adulthood: data from five cohorts in low- and middle-income countries. Int J Epidemiol. 2011;40:47–62.
Pettitt DJ, Forman MR, Hanson RL, Knowler WC, Bennett PH. Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. Lancet. 1997;350:166–8.
Parikh NI, Hwang S-J, Ingelsson E, Benjamin EJ, Fox CS, Vasan RS, et al. Breastfeeding in infancy and adult cardiovascular disease risk factors. Am J Med. 2009;122:656–63.
Ravelli AC, van der Meulen JH, Osmond C, Barker DJ, Bleker OP. Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch Dis Child. 2000;82:248–52.
Martin RM, Ben-Shlomo Y, Gunnell D, Elwood P, Yarnell JWG, Smith GD. Breast feeding and cardiovascular disease risk factors, incidence, and mortality: the Caerphilly study. J Epidemiol Community Health. 2005;59:121–9.
Rich-Edwards JW, Stampfer MJ, Manson JAE, Rosner B, Hu FB, Michels KB, et al. Breastfeeding during infancy and the risk of cardiovascular disease in adulthood. Epidemiology. 2004;15:550–6.
Martin RM, Ebrahim S, Griffin M, Smith GD, Nicolaides AN, Georgiou N, et al. Breastfeeding and atherosclerosis: intima-media thickness and plaques at 65-year follow-up of the Boyd Orr cohort. Arterioscler Thromb Vasc Biol. 2005;25:1482–8.
Abdullah A, Peeters A, de Courten M, Stoelwinder J. The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies. Diabetes Res Clin Pract. 2010;89:309–19.
Li R, Scanlon KS, Serdula MK. The validity and reliability of maternal recall of breastfeeding practice. Nutr Rev. 2005;63:103–10.
Bernardo Lessa Horta has a Scientific Productivity Scholarship (Level 1A) from the Brazilian Research Council (CNPq). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001.
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This article is part of the Topical Collection on Pediatric Type 2 and Monogenic Diabetes
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Horta, B.L., de Lima, N.P. Breastfeeding and Type 2 Diabetes: Systematic Review and Meta-Analysis. Curr Diab Rep 19, 1 (2019). https://doi.org/10.1007/s11892-019-1121-x
- Human milk
- Type 2 diabetes