Current Diabetes Reports

, 17:123 | Cite as

Health Benefits of Fasting and Caloric Restriction

  • Saeid Golbidi
  • Andreas Daiber
  • Bato Korac
  • Huige Li
  • M. Faadiel Essop
  • Ismail LaherEmail author
Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Lifestyle Management to Reduce Diabetes/Cardiovascular Risk


Purpose of Review

Obesity and obesity-related diseases, largely resulting from urbanization and behavioral changes, are now of global importance. Energy restriction, though, is associated with health improvements and increased longevity. We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases, particularly diabetes.

Recent Findings

Calorie restriction triggers a complex series of intricate events, including activation of cellular stress response elements, improved autophagy, modification of apoptosis, and alteration in hormonal balance. Intermittent fasting is not only more acceptable to patients, but it also prevents some of the adverse effects of chronic calorie restriction, especially malnutrition.


There are many somatic and potentially psychologic benefits of fasting or intermittent calorie restriction. However, some behavioral modifications related to abstinence of binge eating following a fasting period are crucial in maintaining the desired favorable outcomes.


Calorie restriction Diabetes Adipose tissue Oxidative stress 


Compliance with Ethical Standards

Conflict of Interest

Saeid Golbidi, Andreas Daiber, Bato Korac, Huige Li, M. Faadiel Essop, and Ismail Laher declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Saeid Golbidi
    • 1
  • Andreas Daiber
    • 2
  • Bato Korac
    • 3
  • Huige Li
    • 4
  • M. Faadiel Essop
    • 5
  • Ismail Laher
    • 1
    Email author
  1. 1.Faculty of Medicine, Department of Pharmacology and TherapeuticsThe University of British ColumbiaVancouverCanada
  2. 2.Center of Cardiology, Cardiology 1Medical Center of the Johannes Gutenberg UniversityMainzGermany
  3. 3.Department of Physiology, Institute for Biological Research “Sinisa Stankovic”University of BelgradeBelgradeSerbia
  4. 4.Department of PharmacologyMedical Center of the Johannes Gutenberg UniversityMainzGermany
  5. 5.Department of Physiological SciencesStellenbosch UniversityStellenboschSouth Africa

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