Advertisement

Current Diabetes Reports

, 16:3 | Cite as

Type 2 Diabetes and Hearing Impairment

  • Elizabeth Purchase HelznerEmail author
  • Kevin J. Contrera
Diabetes Epidemiology (NM Maruthur, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Diabetes Epidemiology

Abstract

Hearing impairment (HI) and type 2 diabetes are both highly prevalent disabling conditions. Type 2 diabetes has been modestly associated with a higher likelihood of HI in many, but not all, population-based studies, with stronger associations found in studies that included younger age groups. Pathophysiologic studies suggest that persons with diabetes are predisposed to HI in the higher frequencies. Proposed mechanisms underlying the association between diabetes and HI include the combined contributions of hyperglycemia and oxidative stress to cochlear microangiopathy and auditory neuropathy. In this review, we highlight recent population-based studies of type 2 diabetes and HI and examine evidence for diabetes-induced pathophysiologic changes that may result in damage to the auditory system.

Keywords

Diabetes Hearing Epidemiology Presbycusis 

Abbreviations

PTA

Pure-tone average

HI

Hearing impairment

kHz

Kilohertz

dB

Decibels, expressed as hearing level

ABR

Auditory brainstem response

Notes

Compliance with Ethics Standards

Conflict of Interest

Elizabeth Purchase Helzner and Kevin Contrera declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Agrawal Y, Platz EA, Niparko JK. Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, 1999–2004. Arch Intern Med. 2008;168(14):1522–30. doi: 10.1001/archinte.168.14.1522.CrossRefPubMedGoogle Scholar
  2. 2.
    Lin FR, Niparko JK, Ferrucci L. Hearing loss prevalence in the United States. Arch Intern Med. 2011;171(20):1851–2. doi: 10.1001/archinternmed.2011.506.PubMedCentralCrossRefPubMedGoogle Scholar
  3. 3.
    Contrera KJ, Betz J, Genther DJ, Lin FR. Association of Hearing Impairment and Mortality in the National Health and Nutrition Examination Survey. JAMA Otolaryngol Head Neck Surg. 2015;141(10):944–46. doi: 10.1001/jamaoto.2015.1762.
  4. 4.
    Helzner EP. Age related hearing loss. In: Newman AB, Cauley JA, editors. The epidemiology of aging. Dordrecht: Springer; 2012.Google Scholar
  5. 5.•
    Horikawa C, Kodama S, Tanaka S, Fujihara K, Hirasawa R, Yachi Y, et al. Diabetes and risk of hearing impairment in adults: a meta-analysis. J Clin Endocrinol Metab. 2013;98(1):51–8. doi: 10.1210/jc.2012-2119. Meta-analysis of thirteen studies, pooling the data of 20,194 individuals, 7,377 of whom had HI based on a pure-tone audiometry. Compared to non-diabetic patients, the odds of HI among diabetic patients were 2.15 (95% CI 1.72–2.68). The association was stronger among adults <60 years compared to those ≥60 years.CrossRefPubMedGoogle Scholar
  6. 6.
    Prevention CfDCa. National diabetes statistics report: estimates of diabetes and its burden in the United States. Atlanta: U.S. Department of Health and Human Services; 2014.Google Scholar
  7. 7.
    Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806–14. doi: 10.1001/jama.2014.732.CrossRefPubMedGoogle Scholar
  8. 8.
    National Diabetes Data Group NIoDaDaKD. Diabetes in America. Bethesda: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 1995.Google Scholar
  9. 9.••
    Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay MF. Effects of type 2 diabetes mellitus on cochlear structure in humans. Arch Otolaryngol Head Neck Surg. 2006;132(9):934–8. doi: 10.1001/archotol.132.9.934. This study of temporal bones from 18 type 2 diabetic patients and 26 age-matched controls found that, compared to controls, diabetic patients demonstrated greater reduction in cochlear hair cells, and thicker vessel walls and greater atrophy of the stria vascularis.CrossRefPubMedGoogle Scholar
  10. 10.
    Helzner EP, Cauley JA, Pratt SR, Wisniewski SR, Zmuda JM, Talbott EO, et al. Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53(12):2119–27. doi: 10.1111/j.1532-5415.2005.00525.x.CrossRefPubMedGoogle Scholar
  11. 11.
    Bainbridge KE, Hoffman HJ, Cowie CC. Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004. Ann Intern Med. 2008;149:1–10.PubMedCentralCrossRefPubMedGoogle Scholar
  12. 12.
    Dalton DS, Cruickshanks KJ, Klein R, Klein BE, Wiley TL. Association of NIDDM and hearing loss. Diabetes Care. 1998;21(9):1540–4.CrossRefPubMedGoogle Scholar
  13. 13.
    Mitchell P, Gopinath B, McMahon CM, Rochtchina E, Wang JJ, Boyages SC, et al. Relationship of Type 2 diabetes to the prevalence, incidence and progression of age-related hearing loss. Diabet Med. 2009;26(5):483–8. doi: 10.1111/j.1464-5491.2009.02710.x.CrossRefPubMedGoogle Scholar
  14. 14.
    Gates GA, Cobb JL, D’Agostino RB, Wolf PA. The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors. Arch Otolaryngol Head Neck Surg. 1993;119(2):156–61. doi: 10.1001/archotol.1993.01880140038006.CrossRefPubMedGoogle Scholar
  15. 15.
    Lin FR, Thorpe R, Gordon-Salant S, Ferrucci L. Hearing loss prevalence and risk factors among older adults in the United States. J Gerontol Ser A Biol Med Sci. 2011;66(5):582–90. doi: 10.1093/gerona/glr002.CrossRefGoogle Scholar
  16. 16.
    Cheng YJ, Gregg EW, Saaddine JB, Imperatore G, Zhang X, Albright AL. Three decade change in the prevalence of hearing impairment and its association with diabetes in the United States. Prev Med. 2009;49(5):360–4.CrossRefPubMedGoogle Scholar
  17. 17.
    Zipf G, Chiaapa M, Porter K, Ostchega Y, Lewis B, Dostal J. The National Health and Nutrition Examination Survey: Plan and Operations, 1999–2010. Vital Health Stat. 2013;1(56): National Center for Health Statistics.Google Scholar
  18. 18.•
    Akinpelu OV, Mujica-Mota M, Daniel SJ. Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis. Laryngoscope. 2014;124(3):767–76. doi: 10.1002/lary.24354. Meta-analysis of six studies (pooled sample of 900 type 2 diabetic patients and 5323 non-diabetic controls). Diabetic patients had 91% higher odds of HI than non-diabetic controls (OR 1.91, 95% CI 1.47–2.49). The association was stronger among adults <65 years compared to those ≥65 years.CrossRefPubMedGoogle Scholar
  19. 19.
    Szalat A, Raz I. Metabolic syndrome and microangiopathy. Isr Med Assoc J. 2006;8(6):424–5.PubMedGoogle Scholar
  20. 20.
    Guerci B, Kearney-Schwartz A, Bohme P, Zannad F, Drouin P. Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function. Diabetes Metab. 2001;27(4 Pt 1):425–34.PubMedGoogle Scholar
  21. 21.
    Taslipinar A, Yaman H, Yilmaz MI, Demirbas S, Saglam M, Taslipinar MY, et al. The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy. Scand J Clin Lab Invest. 2011;71(7):606–12. doi: 10.3109/00365513.2011.598944.CrossRefPubMedGoogle Scholar
  22. 22.
    Falbe-Hansen J. Histochemical studies on glycogen in the cochlea of drug-injected guinea pigs and alloxan-diabetic white rats. Acta Oto-Laryngologica Suppl. 1964; 57, Iss.sup188.Google Scholar
  23. 23.
    Nakae S, Tachibana M. The cochlea of the spontaneously diabetic mouse. II. Electron microscopic observations of non-obese diabetic mice. Arch Otorhinolaryngol. 1986;243(5):313–6.CrossRefPubMedGoogle Scholar
  24. 24.
    Raynor E, Robison WG, Garrett CG, McGuirt WT, Pillsbury HC, Prazma J. Consumption of a high-galactose diet induces diabetic-like changes in the inner ear. Otolaryngol Head Neck Surg. 1995;113(6):748–54.CrossRefPubMedGoogle Scholar
  25. 25.
    Makishima K, Tanaka K. Pathological changes of the inner ear and central auditory pathway in diabetic patients. Ann Otol Rhinol Laryngol. 1971;80(2):218–28.PubMedGoogle Scholar
  26. 26.
    Sonneville R, den Hertog HM, Guiza F, Gunst J, Derese I, Wouters PJ, et al. Impact of hyperglycemia on neuropathological alterations during critical illness. J Clin Endocrinol Metab. 2012;97(6):2113–23. doi: 10.1210/jc.2011-2971.CrossRefPubMedGoogle Scholar
  27. 27.
    Malone JI, Hanna S, Saporta S, Mervis RF, Park CR, Chong L, et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatr Diabetes. 2008;9(6):531–9. doi: 10.1111/j.1399-5448.2008.00431.x.CrossRefPubMedGoogle Scholar
  28. 28.
    Hinder LM, Vincent AM, Burant CF, Pennathur S, Feldman EL. Bioenergetics in diabetic neuropathy: what we need to know. J Peripher Nerv Syst. 2012;17 Suppl 2:10–4. doi: 10.1111/j.1529-8027.2012.00389.x.PubMedCentralCrossRefPubMedGoogle Scholar
  29. 29.
    Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–20. doi: 10.1038/414813a.CrossRefPubMedGoogle Scholar
  30. 30.
    Vincent AM, Olzmann JA, Brownlee M, Sivitz WI, Russell JW. Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes. 2004;53(3):726–34.CrossRefPubMedGoogle Scholar
  31. 31.
    Bansal V, Kalita J, Misra UK. Diabetic neuropathy. Postgrad Med J. 2006;82(964):95–100. doi: 10.1136/pgmj.2005.036137.PubMedCentralCrossRefPubMedGoogle Scholar
  32. 32.
    Kavanagh KT, Beardsley JV. Brain stem auditory evoked response. Ann Otol Rhinol Laryngol Suppl. 1979;88(4 Pt 2 Suppl 58):1–28.CrossRefPubMedGoogle Scholar
  33. 33.
    Burkard RF, Eggermont JJ, Don M. Auditory evoked potentials: basic principles and clinical application. Philadelphia: Lippincott Williams & Wilkins; 2007.Google Scholar
  34. 34.
    Vaughan N, James K, McDermott D, Griest S, Fausti S. Auditory brainstem response differences in diabetic and non-diabetic veterans. J Am Acad Audiol. 2007;18(10):863–71.CrossRefPubMedGoogle Scholar
  35. 35.
    Ernfors P, Van De Water T, Loring J, Jaenisch R. Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron. 1995;14(6):1153–64.CrossRefPubMedGoogle Scholar
  36. 36.
    Fritzsch B, Silos-Santiago I, Bianchi LM, Farinas I. The role of neurotrophic factors in regulating the development of inner ear innervation. Trends Neurosci. 1997;20(4):159–64.CrossRefPubMedGoogle Scholar
  37. 37.
    Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. 2007;50(2):431–8. doi: 10.1007/s00125-006-0537-4.CrossRefPubMedGoogle Scholar
  38. 38.
    Huang TJ, Sayers NM, Verkhratsky A, Fernyhough P. Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats. Exp Neurol. 2005;194(1):279–83. doi: 10.1016/j.expneurol.2005.03.001.CrossRefPubMedGoogle Scholar
  39. 39.
    Jorgensen MB, Buch NH. Studies on inner-ear function and cranial nerves in diabetics. Acta Otolaryngol. 1961;53:350–64.CrossRefPubMedGoogle Scholar
  40. 40.
    Gordon-Salant S. Hearing loss and aging: new research findings and clinical implications. J Rehabil Res Dev. 2005;42(4 Suppl 2):9–24.CrossRefPubMedGoogle Scholar
  41. 41.
    Gratton MA, Schmiedt RA, Schulte BA. Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis. Hear Res. 1996;102(1–2):181–90.CrossRefPubMedGoogle Scholar
  42. 42.
    Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 2013;303:30–8. doi: 10.1016/j.heares.2013.01.021.PubMedCentralCrossRefPubMedGoogle Scholar
  43. 43.
    Vasilyeva ON, Frisina ST, Zhu X, Walton JP, Frisina RD. Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis. Hear Res. 2009;249(1–2):44–53. doi: 10.1016/j.heares.2009.01.007.PubMedCentralCrossRefPubMedGoogle Scholar
  44. 44.
    Yamasoba T, Oka Y, Tsukuda K, Nakamura M, Kaga K. Auditory findings in patients with maternally inherited diabetes and deafness harboring a point mutation in the mitochondrial transfer RNA(Leu) (UUR) gene. Laryngoscope. 1996;106(1 Pt 1):49–53.CrossRefPubMedGoogle Scholar
  45. 45.
    Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26(4):435–9. doi: 10.1038/82565.CrossRefPubMedGoogle Scholar
  46. 46.
    Newkirk JE, Taylor RW, Howell N, Bindoff LA, Chinnery PF, Alberti KG, et al. Maternally inherited diabetes and deafness: prevalence in a hospital diabetic population. Diabet Med. 1997;14(6):457–60. doi: 10.1002/(SICI)1096-9136(199706)14:6<457::AID-DIA372>3.0.CO;2-W.CrossRefPubMedGoogle Scholar
  47. 47.
    Khardori R, Stephens JW, Page OC, Dow RS. Diabetes mellitus and optic atrophy in two siblings: a report on a new association and a review of the literature. Diabetes Care. 1983;6(1):67–70.CrossRefPubMedGoogle Scholar
  48. 48.
    Eller P, Foger B, Gander R, Sauper T, Lechleitner M, Finkenstedt G, et al. Wolfram syndrome: a clinical and molecular genetic analysis. J Med Genet. 2001;38(11):E37.PubMedCentralCrossRefPubMedGoogle Scholar
  49. 49.
    Mayeda ER, Whitmer RA, Yaffe K. Diabetes and cognition. Clin Geriatr Med. 2015;31(1):101–15. doi: 10.1016/j.cger.2014.08.021. ix.
  50. 50.
    Diabetes Public Health Resource. Health Status and Disability. Centers for Disease Control and Prevention web site. [http://www.cdc.gov/diabetes/statistics/health_status_national.htm]. Last updated October 5, 2012. Accessed 28 Oct 2015.
  51. 51.
    Diabetes Fast Stats. Centers for Disease Control and Prevention Web site. http://www.cdc.gov/nchs/fastats/diabetes.htm Last updated September 29, 2015. Accessed 28 Oct 2015.

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Elizabeth Purchase Helzner
    • 1
    Email author
  • Kevin J. Contrera
    • 2
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthSUNY Downstate Medical CenterBrooklynUSA
  2. 2.Johns Hopkins University School of MedicineBaltimoreUSA

Personalised recommendations