Current Diabetes Reports

, 15:76 | Cite as

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

  • William T. Moore
  • Suzanne M. Bowser
  • Dane W. Fausnacht
  • Linda L. Staley
  • Kyung-Shin Suh
  • Dongmin LiuEmail author
Lifestyle Management to Reduce Diabetes\/Cardiovascular Risk (E Mayer-Davis and C Shay, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Lifestyle Management to Reduce Diabetes/Cardiovascular Risk


Approximately 366 million people worldwide have been diagnosed with type-2 diabetes (T2D). Chronic insulin resistance, decreased functional β-cell mass, and elevated blood glucose are defining characteristics of T2D. Great advances have been made in understanding the pathogenesis of T2D with respect to the effects of dietary macronutrient composition and energy intake on β-cell physiology and glucose homeostasis. It has been further established that obesity is a leading pathogenic factor for developing insulin resistance. However, insulin resistance may not progress to T2D unless β-cells are unable to secret an adequate amount of insulin to compensate for decreased insulin sensitivity. Therefore, pancreatic β-cell dysfunction plays an important role in the development of overt diabetes. This paper reviews recent research findings on the effects of several micronutrients (zinc, vitamin D, iron, vitamin A), leucine, and the phytochemical, genistein on pancreatic β-cell physiology with emphasis on their effects on insulin secretion, specifically in the context of T2D.


Insulin secretion Zinc Vitamin D Iron Vitamin A Genistein 


Compliance with Ethics Guidelines

Conflict of Interest

The authors declare that they have no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • William T. Moore
    • 1
  • Suzanne M. Bowser
    • 1
  • Dane W. Fausnacht
    • 1
  • Linda L. Staley
    • 1
  • Kyung-Shin Suh
    • 1
  • Dongmin Liu
    • 1
    Email author
  1. 1.Department of Human Nutrition, Foods and Exercises, College of Agricultural and Life SciencesVirginia Tech Corporate Research CenterBlacksburgUSA

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