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Type 2 Diabetes: Is Pancreas Transplantation an Option?

  • Transplantation (A Pileggi, Section Editor)
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Abstract

Transplantation of the whole vascularized pancreas can provide insulin secretion in patients with insulin-dependent, type 1 diabetes mellitus (T1D). It restores euglycemia in most patients, with the potential to impact the chronic diabetic complications and quality of life. Pancreas transplantation (PT) is presently controversial for type 2 diabetes mellitus (T2D). For those patients with severe glycemic dysregulation, T2D can be associated with the same life-threatening sequelae as T1D such as severe hypoglycemia and kidney failure that could be corrected by pancreas (and kidney) transplantation. Thus, clinical indications and patient selection criteria are very important. This chapter will review the current status of PT for T2D and discuss the options and evolution of transplant perspectives.

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Compliance with Ethics Guidelines

Conflict of Interest

Gaetano Ciancio declares that he has no conflict of interest.

George W. Burke has received financial support through a grant and support for travel to meetings from the Institut Georges Lopez (IGL).

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. The DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA

    Gaetano Ciancio & George W. Burke

  2. The Lillian Jean Kaplan Renal Transplant Center, Miller School of Medicine, University of Miami, Miami, FL, USA

    Gaetano Ciancio & George W. Burke

  3. Division of Transplantation, Miller School of Medicine, University of Miami, Miami, FL, USA

    Gaetano Ciancio & George W. Burke

  4. The Miami Transplant Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Gaetano Ciancio & George W. Burke

  5. Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    George W. Burke

  6. Department of Surgery, Division of Transplantation, Miller School of Medicine, University of Miami, Post Office Box 012440, Miami, FL, 33101, USA

    Gaetano Ciancio & George W. Burke

Authors
  1. Gaetano Ciancio
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  2. George W. Burke
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Correspondence to Gaetano Ciancio.

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This article is part of the Topical Collection on Transplantation

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Ciancio, G., Burke, G.W. Type 2 Diabetes: Is Pancreas Transplantation an Option?. Curr Diab Rep 14, 542 (2014). https://doi.org/10.1007/s11892-014-0542-9

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  • DOI: https://doi.org/10.1007/s11892-014-0542-9

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