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Bioengineered Sites for Islet Cell Transplantation

  • Transplantation (A Pileggi, Section Editor)
  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Although islet transplantation has demonstrated its potential use in treating type 1 diabetes, this remains limited by the need for daily immunosuppression. Islet encapsulation was then proposed with a view to avoiding any immunosuppressive regimen and related side effects. In order to obtain a standard clinical procedure in terms of safety and reproducibility, two important factors have to be taken into account: the encapsulation design (which determines the graft volume) and the implantation site. Indeed, the implantation site should meet certain requirements: (1) its space must be large enough for the volume of transplanted tissues; (2) there must be proximity to abundant vascularization with a good oxygen supply; (3) there must be real-time access to physiologically representative blood glucose levels; (4) there must be easy access for implantation and the reversibility of the procedure (for safety); and finally, (5) the site should have minimal early inflammatory reaction and promote long-term survival. The aim of this article is to review possible preclinical/clinical implantation sites (in comparison with free islets) for encapsulated islet transplantation as a function of the encapsulation design: macro/microcapsules and conformal coating.

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Sophie Vériter declares no conflict of interest.

Pierre Gianello declares no conflict of interest.

Denis Dufrane declares no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Unité de thérapie cellulaire endocrine, Centre de thérapie tissulaire et cellulaire, Cliniques universitaires Saint Luc, Tour Franklin +1 Sud, Avenue Mounier, 1200, Brussels, Belgium

    Sophie Vériter & Denis Dufrane

  2. Pôle de Chirurgie Expérimentale et Transplantation, Institut de Recherche Expérimentale et Clinique, Secteur des Sciences de la Santé, Université catholique de Louvain, Tour Harvey, 5570,+4, Avenue Hippocrate, 1200, Brussels, Belgium

    Pierre Gianello

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  1. Sophie Vériter
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  2. Pierre Gianello
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  3. Denis Dufrane
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Correspondence to Denis Dufrane.

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Vériter, S., Gianello, P. & Dufrane, D. Bioengineered Sites for Islet Cell Transplantation. Curr Diab Rep 13, 745–755 (2013). https://doi.org/10.1007/s11892-013-0412-x

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  • DOI: https://doi.org/10.1007/s11892-013-0412-x

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