Diabetes Mellitus and Inflammation

Abstract

Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.

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Conflict of Interest

Eric Lontchi-Yimagou declares that he has no conflict of interest.

Eugene Sobngwi declares that he has no conflict of interest.

Tandi E Matsha declares that she has no conflict of interest.

Andre Pascal Kengne declares that he has no conflict of interest.

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Correspondence to Andre Pascal Kengne.

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Lontchi-Yimagou, E., Sobngwi, E., Matsha, T.E. et al. Diabetes Mellitus and Inflammation. Curr Diab Rep 13, 435–444 (2013). https://doi.org/10.1007/s11892-013-0375-y

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Keywords

  • Diabetes mellitus
  • Inflammation
  • Biomarkers
  • Adipocytes
  • Cytokines
  • Adipokines
  • Interleukin