References
Ogawa N, List JF, Habener JF, Maki T: Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes 2004, 53:1700–1705.
Chatenoud L, Primo J, Bach JF: CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 1997, 158:2947–2954.
Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al.: Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005, 352:2598–2608.
Herold KC, Gitelman SE, Masharani U, et al.: A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005, 54:1763–1769.
Huurman VA, Hilbrands R, Pinkse GG, et al.: Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS ONE 2008, 3:e2435.
Brantly ML, Wittes JT, Vogelmeier CF, et al.: Use of a highly purified alpha 1-antitrypsin standard to establish ranges for the common normal and deficient alpha 1-antitrypsin phenotypes. Chest 1991, 100:703–708.
Breit SN, Wakefield D, Robinson JP, et al.: The role of alpha 1-antitrypsin deficiency in the pathogenesis of immune disorders. Clin Immunol Immunopathol 1985, 35:363–380.
Churg A, Dai J, Zay K, et al.: Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest 2001, 81:1119–1131.
Song S, Goudy K, Campbell-Thompson M, et al.: Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice. Gene Ther 2004, 11:181–186.
Lewis EC, Shapiro L, Bowers OJ, Dinarello CA: Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A 2005, 102:12153–12158.
Lewis EC, Mizrahi M, Toledano M, et al.: alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A 2008, 105:16236–16241.
Zhang B, Lu Y, Campbell-Thompson M, et al.: Alpha 1 antitrypsin protects ta-cells from apoptosis. Diabetes 2007, 56:1316–1323.
Koulmanda M, Bhasin M, Hoffman L, et al.: Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A 2008, 105:16242–16247.
Bruning JC, Winnay J, Bonner-Weir S, et al.: Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1999, 88:561–572.
Butler AE, Janson J, Bonner-Weir S, et al.: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102–110.
Koulmanda M, Budo E, Bonner-Weir S, et al.: Modi-fication of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A 2007, 104:13074–13079.
Crystal RG: Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J Clin Invest 1990, 85:1343–1352.
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Weir, G.C., Koulamnda, M. Control of inflammation with alpha1-antitrypsin: A potential treatment for islet transplantation and new-onset type 1 diabetes. Curr Diab Rep 9, 100–102 (2009). https://doi.org/10.1007/s11892-009-0018-5
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DOI: https://doi.org/10.1007/s11892-009-0018-5