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The major diabetes prevention trials

Current Diabetes Reports volume 3, pages 115–122 (2003)Cite this article

Abstract

Type 2 diabetes (T2D) is a devastating disease with multiple complications affecting many tissues, most notably the cardiovascular system. To be able to prevent a chronic disease such as T2D, certain requirements have to be met. Knowledge about its natural history with a preclinical phase, modifiable risk factors, effective and simple screening tools to identify high-risk subjects, and effective intervention that is affordable and acceptable are necessary. In addition, the efficacy of the intervention has to be proven under a clinical trial setting. Several major lifestyle intervention trials have been successfully carried out, with consistent results: the risk of T2D in high-risk subjects can be halved, the effect of lifestyle changes is rapid, and benefits are similar in different ethnic groups. Thus, the prevention of T2D is possible in most high-risk subjects, but how to achieve this at the population level remains a major challenge.

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Affiliations

  1. Department of Epidemiology and Health Promotion, National Public Health Institute, Diabetes and Genetic Epidemiology Unit, Mannerheimintie 166, 00300, Helsinki, Finland

    Jaakko Tuomilehto MD, MPolSc, PhD

Authors
  1. Jaakko Tuomilehto MD, MPolSc, PhD
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  2. Jaana Lindström MSc
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Tuomilehto, J., Lindström, J. The major diabetes prevention trials. Curr Diab Rep 3, 115–122 (2003). https://doi.org/10.1007/s11892-003-0034-9

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  • DOI: https://doi.org/10.1007/s11892-003-0034-9

Keywords

  • Gestational Diabetes Mellitus
  • Impaired Glucose Tolerance
  • Lifestyle Intervention
  • Acarbose
  • Troglitazone