References
Mogensen CE, Christensen CK: Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984, 311:89–93.
Parving H-H, Oxenboll B, Svendsen PA: Early detection of patients at risk of developing diabetic nephropathy. A prospective study of urinary albumin excretion. Acta Endocrinol 1982, 100:550–555.
Mathiesen ER, Oxenboll B, Johansen K, et al.: Incipient nephropathy in type 1 (insulin-dependent) diabetes. Diabetologia 1984, 26:406–410.
Bakris GL: Microalbuminuria: prognostic implications. Curr Opin Nephrol Hypertens 1996, 5:219–223.
Jager A, Kostense PJ, Ruhe HG, et al.: Microalbuminuria and peripheral arterial disease are independent predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects: five-year follow-up of the Hoorn Study. Arterioscler Thromb Vasc Biol 1999, 19:617–624.
Tuttle KR, Puhlman ME, Cooney SK, Short R: Urinary albumin and insulin as predictors of coronary artery disease: an angiographic study. Am J Kidney Dis 1999, 34:918–925.
Valmadrid CT, Klein R, Moss SE, Klein BE: The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with olderonset diabetes mellitus. Arch Intern Med 2000, 160:1093–1100.
Jensen JS, Borch-Johnsen K, Jensen G, Feldt-Rasmussen B: Microalbuminuria reflects a generalized transvascular albumin leakiness in clinically healthy subjects. Clin Sci (Colch) 1995, 88:629–633.
Agewall S, Wikstrand J, Ljungman S, Fagerberg B: Usefulness of microalbuminuria in predicting cardiovascular mortality in treated hypertensive men with and without diabetes mellitus. Risk Factor Intervention Study Group. Am J Cardiol 1997, 80:164–169.
Jarrett RJ, Viberti GC, Argyropoulos A, et al.: Microalbuminuria predicts mortality in non-insulin-dependent diabetics. Diabet Med 1984, 1:17–19.
Chavers BM, Bilous RW, Ellis EN, et al.: Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria. N Engl J Med 1989, 320:966–970.
Fioretto P, Steffes MW, Mauer M: Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria. Diabetes 1994, 43:1358–1364.
Viberti GF: Prognostic significance of albuminuria for the development of nephropathy. J Hypertens Suppl 1995, 13:S87-S89.
Mauer SM, Steffes MW, Ellis EN, et al.: Structural-functional relationships in diabetic nephropathy. J Clin Invest 1984, 74:1143–1155.
Fioretto P, Steffes MW, Sutherland DE, et al.: Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998, 339:69–75.
Del Prete D, Anglani F, Ceol M, et al.: Molecular biology of diabetic glomerulosclerosis. Nephrol Dial Transplant 1998, 13(suppl 8):20–25.
Duncan MR, Frazier KS, Abramson S, et al.: Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 1999, 13:1774–1786.
Flyvbjerg A: Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia 2000, 43:1205–1223.
Gambaro G, Baggio B: Growth factors and the kidney in diabetes mellitus. Crit Rev Clin Lab Sci 1998, 35:117–151.
Ito Y, Aten J, Bende RJ, et al.: Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 1998, 53:853–861.
Murphy M, Godson C, Cannon S, et al.: Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999, 274:5830–5834.
Rossert J, Terraz-Durasnel C, Brideau G: Growth factors, cytokines, and renal fibrosis during the course of diabetic nephropathy. Diabetes Metab 2000, 26(suppl 4):16–24.
Riser BL, Ladson-Wofford S, Sharba A, et al.: TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. Kidney Int 1999, 56:428–439.
Riser BL, Denichilo M, Cortes P, et al.: Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 2000, 11:25–38.
Mclennan SV, Death AK, Fisher EJ, et al.: The role of the mesangial cell and its matrix in the pathogenesis of diabetic nephropathy. Cell Mol Biol 1999, 45:123–135.
Nerlich A, Schleicher E: Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. Am J Pathol 1991, 139:889–899.
Wu K, Setty S, Mauer SM, et al.: Altered kidney matrix gene expression in early stages of experimental diabetes. Acta Anat (Basel) 1997, 158:155–165.
Brown DM, Charonis AS, Furcht LT, et al.: An overview of role of matrix components. Diabetes Care 1991, 14:157–159.
Esposito C, Striker LJ, Patel A, et al.: Molecular analysis of glomerular diseases in renal biopsies: initial results of a collaborative international study. The International Study Group for Molecular Study of Kidney Biopsies. Proc Assoc Am Physicians 1996, 108:209–217.
Adler SG, Feld S, Striker GE, et al.: Glomerular type IV collagen in patients with diabetic nephropathy with and without additional glomerular disease. Kidney Int 2000, 57:2084–2092.
Ledbetter S, Copeland EJ, Noonan D, et al.: Altered steady-state mRNA levels of basement membrane proteins in diabetic mouse kidneys and thromboxane synthase inhibition. Diabetes 1990, 39:196–203.
Yang CW, Hsueh S, Wu MS, et al.: Glomerular transforming growth factor-beta1 mRNA as a marker of glomerulosclerosisapplication in renal biopsies. Nephron 1997, 77:290–297.
Mauer SM, Chavers BM, Steffes MW: Should there be an expanded role for kidney biopsy in the management of patients with type I diabetes? Am J Kidney Dis 1990, 16:96–100.
Glassock RJ, Hirschman GH, Striker GE: Workshop on the use of renal biopsy in research on diabetic nephropathy: a summary report. Am J Kidney Dis 1991, 18:589–592.
Adler SG, Kang SW, Feld S, et al.: Glomerular mRNAs in human type 1 diabetes: biochemical evidence for microalbuminuria as a manifestation of diabetic nephropathy. J Am Soc Nephrol 2001, in press.
Adler SG, Kang SW, Feld S, et al.: In IDDM, elevated glomerular CTGF and collagen alpha2(IV) mRNA levels reflect albuminuria and may predict progression from normoalbuminuria. J Am Soc Nephrol 2000, 11:112A.
Kestila M, Lenkkeri U, Mannikko MEA: Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998, 1:575–582.
Holtzman LB, John PL, Kovari A, et al.: Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 1999, 56:1481–1491.
Adler SG, Shahed A, Kang SW, et al.: 12-lipoxygenase, p38 MAPK, and collagen alpha5(IV) in glomeruli in streptozotocin diabetic nephropathy and in glucose stimulated podocytes. J Am Soc Nephrol 2001, in press.
Kang SW, Adler SG, Lapage J, Natarajan R: Glomerular p38 mitogen-activated protein kinase (MAPK) and MAPK kinase 3/6 mRNA expression and activity are increased in early diabetic nephropathy. Kidney Int 2001, 60:543–552.
Meyer TW, Bennett PH, Nelson RG: Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria. Diabetologia 1999, 42:1341–1344.
Pagtalunan ME, Miller PL, Jumping-Eagle S, et al.: Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997, 99:342–348.
Nakamura T, Ushiyama C, Shimada N, et al.: Effect of the antiplatelet drug dilazep dihydrochloride on urinary podocytes in patients in the early stage of diabetic nephropathy. Diabetes Care 2000, 23:1168–1171.
Nakamura T, Ushiyama C, Suzuki S, et al.: Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant 2000, 15:1379–1383.
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Adler, S.G., Nast, C.C. The meaning of microalbuminuria in type 1 diabetes: The need for a new paradigm. Curr Diab Rep 1, 241–244 (2001). https://doi.org/10.1007/s11892-001-0041-7
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DOI: https://doi.org/10.1007/s11892-001-0041-7