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Current Colorectal Cancer Reports

, Volume 14, Issue 6, pp 242–250 | Cite as

Demystifying the Differences Between Tumor-Initiating Cells and Cancer Stem Cells in Colon Cancer

  • Priya Chatterji
  • Julie Douchin
  • Véronique GirouxEmail author
Basic Science Foundations in Colorectal Cancer (DA Dixon and KE Hamilton, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Basic Science Foundations in Colorectal Cancer

Abstract

Purpose of Review

Tumor-initiating cells and cancer stem cells refer to a subpopulation of self-renewing cells involved in tumor initiation and tumor maintenance, respectively. With this review, we aimed to define the functional and molecular differences between both cell types in the context of colon cancer.

Recent Findings

Recent evidence suggests that the two major stem cell populations in the normal intestinal crypt have tumor-initiating capacity and could be the cell-of-origin in colon cancer. Activation of the Wnt/β-catenin pathway (an early event in mouse intestinal carcinogenesis) in the crypt base columnar stem cells and reserve stem cells leads to adenoma formation, supporting a role in tumor initiation. On the other hand, colon cancer stem cells express several membrane markers facilitating their isolation by FACS and are associated with treatment resistance and higher metastatic potential.

Summary

Tumor-initiating cells and cancer stem cells express distinct markers, display discrete biological functions, and can be studied using different molecular and cellular approaches. While cancer stem cells may be derived from tumor-initiating cells, these terms are not necessarily interchangeable and more likely reflect a specific cell state.

Keywords

Colon cancer Tumor-initiating cells Cancer stem cells Cancer relapse Cell-of-origin Drug resistance 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Priya Chatterji
    • 1
  • Julie Douchin
    • 2
  • Véronique Giroux
    • 2
    • 3
    • 4
    Email author
  1. 1.Division of Gastroenterology, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Anatomy and Cell Biology, Faculty of Medicine and Health SciencesUniversité de SherbrookeSherbrookeCanada
  3. 3.Pavillon de la Recherche Appliquée sur le CancerSherbrookeCanada
  4. 4.Centre de recherche du Centre hospitalier de Sherbrooke (CRCHUS)SherbrookeCanada

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