Current Colorectal Cancer Reports

, Volume 13, Issue 2, pp 101–110 | Cite as

WNT Signaling and Colorectal Cancer

  • Emma M. Schatoff
  • Benjamin I. Leach
  • Lukas E. DowEmail author
Basic Science Foundations in Colorectal Cancer (J Roper, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Basic Science Foundations in Colorectal Cancer


The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.


Colorectal cancer CRC Wnt APC Beta-catenin RSPO 



EMS is supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health under award number T32GM07739 to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program. LED is supported by a K22 Career Development Award from the NCI/NIH (CA 181280-01), with funding from the Starr Cancer Consortium (I8-A8-030) and NIH/NCI (5R01CA195787-02).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Emma M. Schatoff
    • 1
    • 2
  • Benjamin I. Leach
    • 1
    • 3
  • Lukas E. Dow
    • 1
    • 4
    • 5
    Email author
  1. 1.Sandra and Edward Meyer Cancer CenterNew YorkUSA
  2. 2.Weill Cornell/Rockefeller/Sloan-Kettering Tri-I MD-PhD ProgramNew YorkUSA
  3. 3.New York Presbyterian HospitalNew YorkUSA
  4. 4.Department of MedicineNew YorkUSA
  5. 5.Department of BiochemistryWeill Cornell MedicineNew YorkUSA

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