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Advancements in Modeling Colorectal Cancer in Rodents

  • Molecular Biology (S Mainardi, Section Editor)
  • Published:
Current Colorectal Cancer Reports

Abstract

Colorectal cancer (CRC) has become a large burden on the health care system with 700,000 people dying from this disease annually in the world. Rodent cancer models, especially the mouse models, play critical roles in the understanding of CRC etiology and the development of CRC therapies. This review is focused on reporting the significant progress that has been made in CRC studies using transplant models and forward genetics mouse models. Rat CRC models are also described as they were usually skipped in other related reviews. We also try to discuss what needs to be improved in rodent model studies to better serve as the CRC research tools and preclinical models for patient care and treatments.

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Acknowledgements

This work was supported by NCI-PSOC Young Investigator trans-network grant (to H.J.C and Z.W.) and Arnold O. Beckman Postdoctoral fellowship (to H.J.C).

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Authors and Affiliations

  1. Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA

    Huanhuan Joyce Chen

  2. Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yanan Zheng

  3. Cancer Research Program, Houston Methodist Research Institute, Houston, TX, USA

    Zhubo Wei

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Chen, H.J., Zheng, Y. & Wei, Z. Advancements in Modeling Colorectal Cancer in Rodents. Curr Colorectal Cancer Rep 12, 274–280 (2016). https://doi.org/10.1007/s11888-016-0334-5

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