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Prevention of Colorectal Cancer: The Future Is Now

  • Personalized Medicine in Colorectal Cancer (CMS Rocha-Lima, Section Editor)
  • Published:
Current Colorectal Cancer Reports

Abstract

An estimated 140,000 new cases of colorectal cancer (CRC) were diagnosed in the USA in 2013. This review focuses on primary, secondary, and tertiary efforts to improve outcomes for patients at risk of CRC. Primary prevention to prevent the occurrence of CRC should focus on the reduction of modifiable CRC risk factors, including education regarding the deleterious effects of Western diets consisting of red and processed meats and the dangers of a sedentary lifestyle and obesity. Foods containing folates, vitamin D, and calcium may be protective against CRC and their consumption should likely be encouraged. Secondary preventive screening efforts can have a profound effect on reducing mortality by identifying neoplasia when precancerous lesions such as adenomas may be removed or when early-stage CRCs exist. Efforts must be made to increase the uptake of CRC screening on a worldwide level. The most resounding data for pharmacologic success in the prophylaxis of colorectal neoplasia belong to the class of aspirin and nonsteroidal anti-inflammatory drugs. Future therapies improving the efficiency of CRC screening modalities and genomic medical breakthroughs to personalize prophylactic treatments will change the way CRC prevention is viewed.

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Conflict of Interest

Isha N. Ranadive declares that she has no conflict of interest.

Daniel A. Sussman has received financial support through grants from the Bankhead-Coley Team Science Program and Olympus America. American Cancer Society and the Sylvester Comprehensive Cancer Center tomy list of grants. I have served on an advisory board for Exact Sciences Corporation.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. University of Miami/Leonard Miller School of Medicine, 1120 NW 14th Street, Clinical Research Building 310 J, Miami, FL, 33136, USA

    Isha N. Ranadive

  2. Division of Gastroenterology, University of Miami/Leonard Miller School of Medicine, 1120 NW 14th Street, Clinical Research Building 310 J, Miami, FL, 33136, USA

    Daniel A. Sussman

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  1. Isha N. Ranadive
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  2. Daniel A. Sussman
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Correspondence to Isha N. Ranadive or Daniel A. Sussman.

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Ranadive, I.N., Sussman, D.A. Prevention of Colorectal Cancer: The Future Is Now. Curr Colorectal Cancer Rep 10, 84–93 (2014). https://doi.org/10.1007/s11888-013-0201-6

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  • DOI: https://doi.org/10.1007/s11888-013-0201-6

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