Current Colorectal Cancer Reports

, Volume 7, Issue 1, pp 42–49

Hyperplastic Polyps: Are They Completely Innocent?


DOI: 10.1007/s11888-010-0080-z

Cite this article as:
Balaguer, F. & Castells, A. Curr Colorectal Cancer Rep (2011) 7: 42. doi:10.1007/s11888-010-0080-z


Until recently, all serrated polyps were classified simply as hyperplastic polyps and were thought to represent benign lesions with no progression to malignancy. However, the recognition during the last decade that some serrated polyps may progress to colorectal cancer through the “serrated neoplastic pathway” has changed the understanding of the significance of these lesions. Classification of serrated polyps is evolving and underscores the fact that morphological changes in serrated lesions are linked to a preneoplastic behavior. This fact has been observed not only in the hyperplastic polyposis syndrome, characterized by multiple or large serrated polyps, but also in the sporadic setting. These findings are particularly important for colorectal cancer prevention, and adequate surveillance programs tailored for patients with serrated polyps are urgently needed.


Hyperplastic polyps Serrated polyps Serrated pathway Colorectal cancer Surveillance Hyperplastic polyposis BRAF CIMP 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gastroenterology DepartmentInstitut de Malalties Digestives i Metabòliques, CIBERehd, IDIBAPS, Hospital ClínicBarcelonaSpain

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