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Molecular Markers of Chemotherapy Response in Colorectal Cancer

  • Published:
Current Colorectal Cancer Reports

Abstract

Biomarkers with predictive value and, to a lesser extent, prognostic value hold the potential to revolutionize the clinical practice of oncology. During the past 20 years, this has been an active field for basic and translational research in colorectal cancer, but no validated biomarkers have been identified or have become routine tools in clinical practice. The past decade has seen significant developments, with translational research projects being allied to randomized trials and the first fruit being borne with the identification of mismatch repair status, KRAS mutations, and possibly topoisomerase 1 expression as biomarkers with the potential to guide clinical practice.

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Authors and Affiliations

  1. Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK

    Michael S. Braun

  2. Section of Oncology & Clinical Research, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK

    Matthew T. Seymour

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  1. Michael S. Braun
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Correspondence to Michael S. Braun.

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Braun, M.S., Seymour, M.T. Molecular Markers of Chemotherapy Response in Colorectal Cancer. Curr Colorectal Cancer Rep 6, 118–125 (2010). https://doi.org/10.1007/s11888-010-0052-3

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