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Curcumin and colorectal cancer: Add spice to your life

  • Published:
Current Colorectal Cancer Reports

Abstract

It is a mystery why colon cancer incidence in the United States is among the highest (530 cases per million) when compared with other countries, such as India (30 cases per million). However, it has been proposed that lifestyle may account for 90% to 95% of all cancers. Curcumin, derived from the spice turmeric (curry powder), is a major component of Indian lifestyle. This agent has been shown to suppress survival, proliferation, invasion, angiogenesis, and metastasis of colon cancer cells through the regulation of various cell signaling pathways and biomarkers, such as nuclear factor-κB, peroxisome proliferator-activated receptor-γ, early growth response-1, β-catenin, mitogen-activated protein kinases, cyclin D1, epidermal growth factor receptor, N-acetyltransferase, cyclooxygenase-2, 5-lipoxygenase, GADD153, p53, B-cell lymphoma 2, basal cell lymphoma-extra large, and ceramide. Animal studies showed that curcumin can protect against various carcinogens mediating colon cancer. Curcumin can also sensitize tumors to chemotherapy and radiation. Clinical trials suggest that curcumin has activity against familial adenomatous polyposis, inflammatory bowel disease, irritable bowel syndrome, and colon cancer. This review discusses the preventive and therapeutic potential of curcumin against colorectal cancer and thus provides “reasoning for seasoning.”

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  1. Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA

    Bharat B. Aggarwal

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  1. Ajaikumar B. Kunnumakkara
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  2. Sushovan Guha
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  3. Bharat B. Aggarwal
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Kunnumakkara, A.B., Guha, S. & Aggarwal, B.B. Curcumin and colorectal cancer: Add spice to your life. Curr colorectal cancer rep 5, 5–14 (2009). https://doi.org/10.1007/s11888-009-0002-0

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