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Computational Analysis of Cardiac Contractile Function

  • Heart Failure (HJ Eisen, Section Editor)
  • Published:
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Abstract

Purpose of Review

Heart failure results in the high incidence and mortality all over the world. Mechanical properties of myocardium are critical determinants of cardiac function, with regional variations in myocardial contractility demonstrated within infarcted ventricles. Quantitative assessment of cardiac contractile function is therefore critical to identify myocardial infarction for the early diagnosis and therapeutic intervention.

Recent Findings

Current advancement of cardiac functional assessments is in pace with the development of imaging techniques. The methods tailored to advanced imaging have been widely used in cardiac magnetic resonance, echocardiography, and optical microscopy. In this review, we introduce fundamental concepts and applications of representative methods for each imaging modality used in both fundamental research and clinical investigations. All these methods have been designed or developed to quantify time-dependent 2-dimensional (2D) or 3D cardiac mechanics, holding great potential to unravel global or regional myocardial deformation and contractile function from end-systole to end-diastole.

Summary

Computational methods to assess cardiac contractile function provide a quantitative insight into the analysis of myocardial mechanics during cardiac development, injury, and remodeling.

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Acknowledgements

This work was supported by NIH R00 HL148493 (YD) and the University of Texas at Dallas.

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  1. Xinyuan Zhang and Ritzia Vinu Alexander contributed equally to this work.

Authors and Affiliations

  1. Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX, 75080, USA

    Xinyuan Zhang, Ritzia Vinu Alexander, Jie Yuan & Yichen Ding

  2. Center for Imaging and Surgical Innovation, The University of Texas at Dallas, Richardson, TX, 75080, USA

    Yichen Ding

  3. Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX, 75390, USA

    Yichen Ding

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  1. Xinyuan Zhang
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  2. Ritzia Vinu Alexander
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The authors would like to express gratitude to all other lab members for constructive discussion. All the authors contributed to the content in this review.

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Correspondence to Yichen Ding.

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Zhang, X., Alexander, R.V., Yuan, J. et al. Computational Analysis of Cardiac Contractile Function. Curr Cardiol Rep 24, 1983–1994 (2022). https://doi.org/10.1007/s11886-022-01814-1

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